Effects of Methylprednisolone on the in Vitro Generation of Human Secondary Cytotoxic Lymphocytes

Hirschberg, Henry; Pfeffer, Per; Hirschberg, Tom; Randazzo, B.

doi:10.1097/00007890-198005000-00014

Cited by 5 publications

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“…The mechanisms of steroid anti-inflammatory and immunosuppressive effects are quite complex [8,11,[26][27][28]30,33]. A func tional down-regulation of the monocytes by corti costeroids has been reported [9].…”

Section: Discussionmentioning

confidence: 99%

Phase II Trial of Methylprednisolone Pulse Therapy in Childhood Chronic Thrombocytopenia

et al. 1987

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Nineteen children with chronic idiopathie thrombocytopenia (ITP) were treated with a single intravenous injection of methylprednisolone (MP), 15 mg/kg/day, for 3 consecutive days. The 3-day pulses gave rise to a positive and fast therapeutic response with increase of the platelet count in about three quarters of the patients. The platelet count remained above 50 × 10⁹/1 for more than 1 month in 10 children. Eight out of them still presented a safe platelet count ( > 50 × 10⁹/1) 4 months after the onset of the therapy. The MP therapy improved the platelet count more in the older children and possibly in the females. No severe side effects were observed. Our results suggest that this therapeutic approach could be useful in the management of acute bleeding episodes in children with chronic ITP.

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