Effects of metoprolol in chagasic patients with severe congestive heart failure

Dávila, Diego F.; Angel, Francisco Arturo López del; Bellabarba, Gabriela Arata de; Donis, José H.

doi:10.1016/s0167-5273(02)00181-x

Cited by 40 publications

(25 citation statements)

References 33 publications

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“…The use of adrenergic beta-blockers in addition to blockade of the renin-angiotensin-aldosterone system (with ACE inhibitors or ARBs) is recommended to reduce the morbidity and mortality associated with the disease. It is assumed that these drugs can help to prevent the worsening of the ventricular remodeling, development of malignant arrhythmias, and sudden death (257) (258) . However, the use of an optimized dose of adrenergic blockers may be hindered in CCC, given bradyarrhythmias and frequent need of amiodarone administration for the treatment of tachyarrhythmias.…”

Section: Drug Treatment Of Heart Failure Caused By Chagas Diseasementioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

312

677

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Section: Drug Treatment Of Heart Failure Caused By Chagas Diseasementioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

312

677

View full text Add to dashboard Cite

“…Digitalis, angiotensin-converting enzyme inhibitors [19] and beta-blockers [20] have proven to be useful in reducing neurohormonal activation in patients with advanced Chagas cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries

Cortez

Providência

Ramos

et al. 2012

WJC

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Due to recent population emigration movements, an epidemic of Chagas disease is currently menacing most developed countries. The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure symptoms, having a previous symptomatic sinus node disease with a pacemaker implant at age of 40 years. The diagnosis was based on serology and myocardial biopsy and the patient was treated with nifurtimox. The authors emphasize the need of a high level of suspicion in patients with suggestive epidemiology and the need of populational screening of specific high risk groups. New treatment options are also discussed.

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“…The most common symptoms are: palpitations (tachycardia) and out-of-rhythm heart beats (extra-systoles and arrhythmias), dizziness, chest pain, shortness of breath in physical exertion, and progressive heart failure [32].…”

Section: Chagas Disease and Renal Damagementioning

confidence: 99%

Renal Disfunction in Chagas Disease

Miguel¹,

Filho²,

Mendes³

et al. 2017

J Bacteriol Parasitol

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Background: Chagas' disease has a wide distribution in South America, having several forms of transmission. The disease's evolution varies according to the parasite/host relationship, presenting diversified progression through the acute, indeterminate and chronic forms. In the cardiac form, there are several clinical and laboratory alterations due to the involvement of several organs, including the kidneys. Actually, a lot of mechanisms are employed for the control and detection of renal damage. It has been proven that before the cardiac inflammatory changes were established, alterations in renal function could be observed due to elevated levels of urea, creatinine and other alterations compatible with the clinical picture of uremia. As well it was possible to verify an anemic state in laboratory animals, thus, it could be a condition known as cardio-anemic-renal syndrome described in patients with heart failure. Although there are studies correlating clinical and laboratory findings of renal dysfunction in Chagas' disease, there is still a need to elucidate some pathways of interaction between chagasic physiopathogeny and renal function.

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Effects of metoprolol in chagasic patients with severe congestive heart failure

Cited by 40 publications

References 33 publications

2 nd Brazilian Consensus on Chagas Disease, 2015

2 nd Brazilian Consensus on Chagas Disease, 2015

Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries

Renal Disfunction in Chagas Disease

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