Effects of Micronutrient Supplementation on CD4+ Cell Count and Anthropometric Parameters in HIV-Positive Adults on Highly Active Antiretroviral Therapy and Treatment Naïve in Sokoto, Nigeria

Yeldu, Mohammed Haruna; Das, Shukla; Bilbis, L. S.; Saidu, Yauba; Njoku, C.O.

doi:10.9734/bjmmr/2016/21736

Cited by 2 publications

(3 citation statements)

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“…This could likely be due to the facts that more female's presents themselves for medical checkup and access HIV services while the males for fear of stigmatization and consequents do not visit the hospital to check their health status until they are sure (NACA (2017). These findings are in agreements with the report of Yeldu et al (2016) and NACA (2018). The same studies also reported that low level of education and low income were high among females than the male counterparts; this could likely be one of the reasons while women are more affected than men.…”

Section: Discussionsupporting

confidence: 94%

“…The participants were not allowed to use another micronutrient or natural health product. Compliance with the study regimens was assessed according to the methods of Kupka and co-researchers (2008), Kawai and coworkers (2010) and adopted by Yeldu et al ;( 2016). The HIV-positive ART patients were asked to bring the unused SelACE ® tablets back during the next Clinic visit.…”

Section: Study Regimenmentioning

confidence: 99%

“…Micronutrient insufficiencies and HIV disease progression are thought to interrelate synergistically progressively aggravating each other (Yeldu et al, 2016)]. Human Immunodeficiency Virus (HIV) infection induces a wide range of immunological alterations causing the progressive development of opportunistic infections and malignancy, which results in acquired immunodeficiency syndrome (AIDS).…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective and immune-reconstitution potentials of carrot-ginger blend among HIV-infected patients taking antiretroviral therapy in Kaduna, Nigeria

Joshua¹,

Abarshi²,

Sani³

et al. 2021

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Hepatotoxicity, micronutrients insufficiency and cost of micronutrient supplements are challenges faced by HIV infected patients on antiretroviral therapy (ART). This study investigated the effect of natural plant micronutrients (vitamins A, C, and E, selenium and Zinc supplements from carrot-ginger (75:25) blend on liver enzymes: Alanine transaminase (ALT) and Aspartate transaminase (AST), CD4 + T lymphocytes and body mass index (BMI) of HIV-infected-patients taking ART. Ninety HIV-infected-patients attending Special Treatment Clinic, Kafanchan General Hospital, Kaduna State, Nigeria, were randomized into three groups of thirty patients each: Group 1 is control group and received ART alone, Group 2 is standard group and received ART with ready to use commercial micronutrient supplement (SelACER supplement) while Group 3 is supplement group and received ART + Carrot-Ginger blend for 90 days. Serum Alanine, Aspartate transaminase, CD4 + T lymphocytes and BMI were assessed using standard methods at baseline (day 0), 30 days, 60 days and 90 days. The results indicated that patients on CarrotGinger blend and SelACER micronutrients supplements show significant (p<0.05) reduction in ALT and AST level. However, there was no significant (p>0.05) difference in patients treated with ART alone when compared to their baseline values. The results indicated that patients on carrot-ginger blend and SelACE® supplements had significant (p<0.05) increase in BMI, CD4+ T-cell counts, serum vitamins A, C, E, selenium and zinc from day zero. There was no significant (p>0.05) difference in patients treated with ART alone compared to their baseline values. In addition, patients on SelACE® supplement revealed significant (p<0.05) difference in their mean BMI, CD4+ T-cell counts, serum vitamins A, C, E, Selenium and Zinc compared to patients on carrot-ginger blend after 90 days. The results also indicated a strong positive association (r=0.97) between serum ALT and AST activity and between CD4+ T cell counts and body mass index (r=0.77) after 90 days. Therefore, micronutrients supplementation of HIV patients during ART treatment with Carrot-Ginger blend could also be a beneficial adjunct to ART due to its potentials to reconstitute the immune system and protect the liver in HIV individuals on ART.

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Section: Discussionsupporting

confidence: 94%

Section: Study Regimenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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