Effects of Midazolam/Low-Dose Ketamine Conscious Intravenous Sedation on Pain, Swelling, and Trismus After Surgical Extraction of Third Molars

Garip, Hasan; Satilmis, Tulin; Dergin, Gühan; Uğurlu, Faysal; Göker, Kamil

doi:10.1016/j.joms.2010.05.035

Cited by 13 publications

(28 citation statements)

References 29 publications

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“…Contrary to these studies [32,34,36]; in our study comparison of facial measurements and mouth opening in both the groups showed overall no statistically significant difference on the 1st, 3rd and 7th post-operative days. Thus sub-mucosal infiltration of 0.5 mg/kg ketamine did not seem to be effective in reducing postoperative swelling or trismus.…”

Section: Discussioncontrasting

confidence: 99%

“…Gupta et al [36] checked postoperative swelling 24 h after surgery; out of 30 patients, only 5 patients showed slight swelling when oral midazolam plus low-dose ketamine was used, whereas 12 patients showed swelling when placebo was used. Garip et al [34] found that facial swelling on postoperative days 1, 3 and 7 was significantly lower in the midazolam plus ketamine group than in midazolam plus placebo group and also mouth opening was significantly better on postoperative days 1 and 3 in the midazolam plus ketamine group.…”

Section: Discussionmentioning

confidence: 99%

“…Recently ketamine has been used in oral and maxillofacial surgical practice as well [14,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…The VAS scores at 30 min and 1, 4, 12 and 24 h post operatively were significantly higher in the local anesthetic alone group than in the combined treatment with local anesthetic and sub anesthetic dose of 0.3 mg/kg ketamine. Garip et al [34] assessed the clinical efficacy of midazolam (0.03 mg/kg) plus low-dose ketamine (0.3 mg/kg) conscious intravenous sedation on relief from or prevention of postoperative pain, swelling, and trismus after the surgical extraction of third molars and concluded that patient compliance to procedure increased and significant post-operative decrease in parameters considered.…”

Section: Discussionmentioning

confidence: 99%

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Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Hadhimane

Shankariah

Neswi

2015

J. Maxillofac. Oral Surg.

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Purpose In this study we assessed the clinical efficacy of sub-mucosal injection of ketamine at sub-anesthetic dose of 0.5 mg/kg on post-operative pain, swelling and trismus following surgical extraction of impacted mandibular third molars. Methods Forty bilaterally symmetrical impacted mandibular third molars in 20 patients who required surgical removal were included in the study. Within the same individual, one of the sites received a test medication whereas the other site was used as control. All patients received nerve blocks with local anesthetic (2 % lignocaine hydrochloride with 1:80,000 adrenaline); the Test group received sub-mucosal infiltration of 0.5 mg/kg of ketamine hydrochloride (without preservative) around the impacted mandibular third molar and along the incision line, while the Placebo group received normal saline infiltration, 10 min before placement of the incision. Results The pain scores on VAS at 30 min, 1, 4, 12 h and 1 day post-operatively was significantly lower in the Test group than in the Placebo group (p \ .05). With respect to facial swelling and mouth opening the Test group and Placebo group showed overall no statistically significant difference (p [ .05) on the 1st, 3rd and 7th post-operative days. Conclusion The sub-mucosal injection of 0.5 mg/kg ketamine administered before surgical removal of impacted mandibular third molars was found to be effective in significantly reducing post-operative pain for the first 24 h.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Recently ketamine has been used in oral and maxillofacial surgical practice as well [14,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Hadhimane

Shankariah

Neswi

2015

J. Maxillofac. Oral Surg.

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“…Previous studies identified that use of ketamine may be limited by adverse effects such as nausea and vomiting, hemodynamic instability, and psychological complications. However, the literature showed that these complications usually cannot be seen with low doses of ketamine, especially if combined with other agents such as propofol, benzodiazepine, and opioids [1,2].…”

mentioning

confidence: 99%

Response to Comment on “Use of propofol in Combination with Remifentanil for Plastic and Reconstructive Surgery”

Sanatkar

2016

Aesth Plast Surg

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Comparative Evaluation of the Intranasal Spray Formulation of Midazolam and Dexmedetomidine in Patients Undergoing Surgical Removal of Impacted Mandibular Third Molars: A Split Mouth Prospective Study

Hiwarkar

Kshirsagar

Singh

et al. 2016

J. Maxillofac. Oral Surg.

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We conclude that Midazolam and Dexmedetomidine are equivalent and can be used in minor oral surgery with minimal complications. These drugs can be used intranasally using nasal atomization device in routine outpatient basis in otherwise normal healthy but anxious patients. All procedures must however be performed in the presence of an anaesthesiologist and with ready availability of emergency drugs and equipment.

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Effects of Midazolam/Low-Dose Ketamine Conscious Intravenous Sedation on Pain, Swelling, and Trismus After Surgical Extraction of Third Molars

Cited by 13 publications

References 29 publications

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Response to Comment on “Use of propofol in Combination with Remifentanil for Plastic and Reconstructive Surgery”

Comparative Evaluation of the Intranasal Spray Formulation of Midazolam and Dexmedetomidine in Patients Undergoing Surgical Removal of Impacted Mandibular Third Molars: A Split Mouth Prospective Study

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