Effects of Mild Exercise on Insulin Sensitivity in Hypertensive Subjects

Rhéaume, Caroline; Waib, Paulo H.; Lacourcière, Yves; Nadeau, André; Cléroux, Jean

doi:10.1161/01.hyp.0000016921.50185.7b

Cited by 16 publications

(24 citation statements)

References 33 publications

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“…The increase in blood flow was similar in the exercise and control sessions. This result is similar to the one observed by Rhéaume et al (28), who showed that previous exercise did not change FBF response to glucose infusion. Thus FBF during hyperinsulinemia was even higher after exercise than after rest.…”

Section: Discussionsupporting

confidence: 92%

“…The lower MSNA and higher FBF achieved during hyperinsulinemia conducted after exercise in healthy subjects suggest that a single bout of exercise could have important clinical implications, especially in some hyperinsulinemic populations, such as obese (10,25,38) and hypertensive (19,28) patients, who present sympathetic activation (2,22,25,27,38) and blunted vasodilation (3,26,38) during acute hyperinsulinemia induced, for example, by a meal. Nevertheless, it is important to point out that the insulin level achieved after meals is lower than the one used in the present study and occurs concomitantly to hyperglycemia (33).…”

Section: Discussionmentioning

confidence: 99%

“…The sympathoexcitatory effect of insulin may have clinical importance in some physiopathological states, such as hypertension and obesity, which commonly present hyperinsulinemia (10,19,25,28,38), sympathetic activation (2,22,27,38), and cardiovascular disturbances (2,22,25,27,38).…”

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confidence: 99%

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Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo¹,

Cardoso²,

Ortega³

et al. 2005

Journal of Applied Physiology

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. Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia. J Appl Physiol 98: 866 -871, 2005. First published November 12, 2004 doi:10.1152/japplphysiol.00251.2004.-Insulin infusion causes muscle vasodilation, despite the increase in sympathetic nerve activity. In contrast, a single bout of exercise decreases sympathetic activity and increases muscle blood flow during the postexercise period. We tested the hypothesis that muscle sympathetic activity would be lower and muscle vasodilation would be higher during hyperinsulinemia performed after a single bout of dynamic exercise. Twenty-one healthy young men randomly underwent two hyperinsulinemic euglycemic clamps performed after 45 min of seated rest (control) or bicycle exercise (50% of peak oxygen uptake). Muscle sympathetic nerve activity (MSNA, microneurography), forearm blood flow (FBF, plethysmography), blood pressure (BP, oscillometric method), and heart rate (HR, ECG) were measured at baseline (90 min after exercise or seated rest) and during hyperinsulinemic euglycemic clamps. Baseline glucose and insulin concentrations were similar in the exercise and control sessions. Insulin sensitivity was unchanged by previous exercise. During the clamp, insulin levels increased similarly in both sessions. As expected, insulin infusion increased MSNA, FBF, BP, and HR in both sessions (23 Ϯ 1 vs. 36 Ϯ 2 bursts/min, 1.8 Ϯ 0.1 vs. 2.2 Ϯ 0.2 ml ⅐ min Ϫ1 ⅐ 100 ml Ϫ1 , 89 Ϯ 2 vs. 92 Ϯ 2 mmHg, and 58 Ϯ 1 vs. 62 Ϯ 1 beats/min, respectively, P Ͻ 0.05). BP and HR were similar between sessions. However, MSNA was significantly lower (27 Ϯ 2 vs. 31 Ϯ 2 bursts/min), and FBF was significantly higher (2.2 Ϯ 0.2 vs. 1.8 Ϯ 0.1 ml ⅐ min Ϫ1 ⅐ 100 ml Ϫ1 , P Ͻ 0.05) in the exercise session compared with the control session. In conclusion, in healthy men, a prolonged bout of dynamic exercise decreases MSNA and increases FBF. These effects persist during acute hyperinsulinemia performed after exercise.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Previous exercise attenuates muscle sympathetic activity and increases blood flow during acute euglycemic hyperinsulinemia

Bisquolo¹,

Cardoso²,

Ortega³

et al. 2005

Journal of Applied Physiology

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“…Reductions in body weight and body fat are known to decrease BP 17) , whereas accumulation of visceral fat will induce insulin resistance 23) . Moreover, it has been reported that mild physical exercise increases the insulin sensitivity in hypertensive subjects 24) . Although parameters concerning insulin sensitivity were not studied in the present study, it is possible that the reduction in insulin resistance through body weight control, and exercise habit might have contributed to the reduction of SBP in the THP group.…”

Section: Discussionmentioning

confidence: 99%

Possible Beneficial Effects of Health Counseling, Given Less Frequently than Ordinary, on Blood Pressure

et al. 2007

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This study was initiated to investigate the effects of health counseling under Total Health Promotion Plan (THP).The study populations consisted of 1,655 working men who had an initial THP-based counseling and a follow-up 3 yr later (the THP group; the counseling was given on a once-three year basis), and 1,655 age-and body mass index (BMI)-matched controls (working men who had no health counseling; the control group). In the THP group, systolic blood pressure (SBP) and the prevalence of excessive alcohol drinking were decreased, and nutritional score was improved, although BMI was increased. In contrast, SBP, BMI and the ratio of excessive drinkers were all increased in the controls. Multiple regression analysis of the THP group showed that the reduction · in SBP was positively associated with the increase in maximal oxygen consumption (VO 2max ) and physical activity scores, as well as the decrease in BMI. In sub-group analyses of the THP group, · VO 2max and physical activity scores were increased, and BMI did not change in the sub-group with marked BP decrease. In the sub-group with marked BP increase, however, BMI was increased, and · VO 2max was decreased. The ratio of excessive drinkers was reduced only in the sub-group with marked BP decrease. The obese-hypertensive subjects in the THP group showed decreases in BMI · and BP, and increases in VO 2max . Thus, these results appeared to suggest that health counseling given even at a low frequency of once in three years prevented the age-associated increase in BP through improvement of physical endurance, decrease in alcohol intake and reduction in body weight.

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“…Reduction of insulin resistance and improvement in endothelial function may also contribute. [19,20] Importantly, this reduction appeared to be independent of the intensity, frequency and type of exercise program. BP reduction was seen in normotensives also and was not inß uenced by initial weight.…”

Section: Increased Physical Activitymentioning

confidence: 92%