Effects of Mindfulness Meditation on Chronic Pain: A Randomized Controlled Trial

Cour, Peter la; Petersen, Marian

doi:10.1111/pme.12605

Cited by 125 publications

(115 citation statements)

References 33 publications

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“…Seven studies obtained a "good" quality rating Fogarty et al, 2015;Ljotsson, Falk, et al, 2010;Parra-Delgado and Latorre-Postigo, 2013;Zautra et al, 2008). Ten studies were judged to be of fair quality, primarily due to being unclear in some aspects of the methods (Cash et al, 2015;Davis and Zautra, 2013;Day et al, 2014;Dowd et al, 2015;Gaylord et al, 2011;la Cour and Petersen, 2015;Morone, Greco, and Weiner, 2008;Wells et al, 2014). Eleven studies were judged to be poor; eight of these were primarily due to issues with completeness of reporting outcome data, such as inadequate or missing ITT analysis or less than 80-percent follow-up Brown and Jones, 2013;Cathcart et al, 2014;Esmer et al, 2010;Meize-Grochowski et al, 2015;Morone et al, 2009;Omidi and Zargar, 2014;PlewsOgan et al, 2005).…”

Section: Study Quality/risk Of Bias For Individual Included Studiesmentioning

confidence: 99%

“…Ten RCTs measured depression outcomes Gaylord et al, 2011;la Cour and Petersen, 2015;Ljotsson, Falk, et al, 2010;MeizeGrochowski et al, 2015;Parra-Delgado and Latorre-Postigo, 2013;Wells et al, 2014;Zautra et al, 2008). Overall, meditation significantly reduced depression (SMD 0.17; CI 0.03, 0.31; 10 RCTs; I 2 0%).…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

“…Pain scales and comparators varied from study to study (Astin et al, 2000;Brown and Jones, 2013;Cash et al, 2015;Cathcart et al, 2014;Davis and Zautra, 2013;Day et al, 2014;Dowd et al, 2015;Esmer et al, 2010;la Cour and Petersen, 2015;Meize-Grochowski et al, 2015;Morone, Greco, and Weiner, 2008;Morone et al, 2009;Omidi and Zargar, 2014;Plews-Ogan et al, 2005;Teixeira, 2010;Wells et al, 2014;Zautra et al, 2008;Parra-Delgado and Latorre-Postigo, 2013;Rahmani and Talepasand, 2015;Gaylord et al, 2011;Ljotsson, Falk, et al, 2010). The median follow-up time was 12 weeks, with a range of four to 60 weeks.…”

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

“…A meta-regression found that treatment effects did not differ significantly when TAU was used as a comparator versus all other comparators. Among the eight RCTs that compared mindfulness meditation to a passive control (either intervention or a waitlist for the primary intervention) (Cash et al, 2015;Cathcart et al, 2014;Day et al, 2014;la Cour and Petersen, 2015;Meize-Grochowski et al, 2015;Morone, Greco, and Weiner, 2008;Rahmani and Talepasand, 2015), one showed a significant effect of meditation on pain (Rahmani and Talepasand, 2015). The pooled effect (displayed in Figure 3.6) was not significant (SMD 0.28; CI −0.46, 1.02; 8 RCTs; I 2 76.5%); considerable heterogeneity was detected.…”

Section: Comparatorsmentioning

confidence: 99%

“…Five (Brown and Jones, 2013;la Cour and Petersen, 2015;Ljotsson, Falk, et al, 2010;Rahmani and Talepasand, 2015) of the 13 studies reporting mental health-related quality of life reported a significant effect, and this effect is significant in the pooled analysis (SMD 0.44; CI 0.18, 0.69; 13 RCTs; I 2 50.6%) (Brown and Jones, 2013;Gaylord et al, 2011;la Cour and Petersen, 2015;Ljotsson, Falk, et al, 2010;Meize-Grochowski et al, 2015;Morone, Greco and Weiner, 2008;Plews-Ogan et al, 2005;Rahmani and Talepasand, 2015;Teixeira, 2010;Wells et al, 2014). 1 Twelve studies measured physical health-related quality of life (Brown and Jones, 2013;Gaylord et al, 2011;la Cour and Petersen, 2015;Ljotsson, Falk, et al, 2010;Meize-Grochowski et al, 2015;Morone, Greco, and Weiner, 2008;Rahmani and Talepasand, 2015;Teixeira, 2010;Wells et al, 2014), and four of these studies used a remote intervention (Ljotsson, Falk, et al, 2010;Meize-Grochowski et al, 2015;Teixeira, 2010). 2 Three (Ljotsson, Falk, et al, 2010;Rahmani and Talepasand, 2015) of the 12 and all of those using a remote intervention report a significant positive effect of meditation on physical health-related quality of life.…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

See 4 more Smart Citations

Mindfulness Meditation for Chronic Pain: A Systematic Review

Maglione¹,

Hempel²,

Maher³

et al. 2016

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Section: Study Quality/risk Of Bias For Individual Included Studiesmentioning

confidence: 99%

Section: Health-related Quality Of Lifementioning

confidence: 99%

Section: Chronic Pain Treatment Response Standardized Mean Differencesmentioning

confidence: 99%

Section: Comparatorsmentioning

confidence: 99%

Section: Health-related Quality Of Lifementioning

confidence: 99%

See 3 more Smart Citations

Mindfulness Meditation for Chronic Pain: A Systematic Review

Maglione¹,

Hempel²,

Maher³

et al. 2016

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Improvements in Physical Function and Pain Interference and Changes in Mental Health Among Patients Seeking Musculoskeletal Care

Zhang,

Singh,

Clement

et al. 2023

JAMA Netw Open

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ImportanceAmong patients seeking care for musculoskeletal conditions, there is mixed evidence regarding whether traditional, structure-based care is associated with improvement in patients’ mental health.ObjectiveTo determine whether improvements in physical function and pain interference are associated with meaningful improvements in anxiety and depression symptoms among patients seeking musculoskeletal care.Design, Setting, and ParticipantsThis cohort study included adult patients treated by an orthopedic department of a tertiary care US academic medical center from June 22, 2015, to February 9, 2022. Eligible participants presented between 4 and 6 times during the study period for 1 or more musculoskeletal conditions and completed Patient-Reported Outcomes Measurement Information System (PROMIS) measures as standard care at each visit.ExposurePROMIS Physical Function and Pain Interference scores.Main Outcomes and MeasuresLinear mixed effects models were used to determine whether improvements in PROMIS Anxiety and PROMIS Depression scores were associated with improved PROMIS Physical Function or Pain Interference scores after controlling for age, gender, race, and PROMIS Depression (for the anxiety model) or PROMIS Anxiety (for the depression model). Clinically meaningful improvement was defined as 3.0 points or more for PROMIS Anxiety and 3.2 points or more for PROMIS Depression.ResultsAmong 11 236 patients (mean [SD] age, 57 [16] years), 7218 (64.2%) were women; 120 (1.1%) were Asian, 1288 (11.5%) were Black, and 9706 (86.4%) were White. Improvements in physical function (β = −0.14; 95% CI, −0.15 to −0.13; P &lt; .001) and pain interference (β = 0.26; 95% CI, 0.25 to 0.26; P &lt; .001) were each associated with improved anxiety symptoms. To reach a clinically meaningful improvement in anxiety symptoms, an improvement of 21 PROMIS points or more (95% CI, 20-23 points) on Physical Function or 12 points or more (95% CI, 12-12 points) on Pain Interference would be required. Improvements in physical function (β = −0.05; 95% CI, −0.06 to −0.04; P &lt; .001) and pain interference (β = 0.04; 95% CI, 0.04 to 0.05; P &lt; .001) were not associated with meaningfully improved depression symptoms.Conclusions and RelevanceIn this cohort study, substantial improvements in physical function and pain interference were required for association with any clinically meaningful improvement in anxiety symptoms, and were not associated with any meaningful improvement in depression symptoms. Patients seeking musculoskeletal care clinicians providing treatment cannot assume that addressing physical health will result in improved symptoms of depression or potentially even sufficiently improved symptoms of anxiety.

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