Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis

Wang, Y L; Gong, Wen-Cheng; Yuan, Qinzi

doi:10.4238/gmr15049070

Cited by 30 publications

(27 citation statements)

References 22 publications

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“…Among the four miRNAs measured, the strongest individual relationship to the development of left ventricular systolic dysfunction in the period up to 6 months after the myocardial infarction was shown by miR–27a [ 49 ]. What is interesting is, that miR–27a participates in the forming and spreading of many types of cancers, as confirmed in numerous research projects [ 50 – 59 ]. Among the four jointly assessed miRNAs mentioned above, a strong individual relationship to post-infarction left ventricular remodelling was also confirmed for miR–150.…”

Section: Mirna and Left Ventricular Remodellingmentioning

confidence: 87%

The relevance of microRNA in post-infarction left ventricular remodelling and heart failure

2019

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Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers are also being sought that would allow for early identification of patients with a high risk of post-infarction remodelling and dysfunction of the left ventricle. In recent years, there has been ever more experimental data that confirms the significance of microRNA in cardiovascular diseases. It has been confirmed that microRNAs are stable in systemic circulation, and can be directly measured in patients’ blood. It has been found that significant changes occur in the concentrations of various types of microRNA in myocardial infarction and heart failure patients. Various types of microRNA are also currently being intensively researched in terms of their usefulness as markers of cardiomyocyte necrosis, and predictors of the post-infarction heart failure development. This paper is a summary of the current knowledge on the significance of microRNA in post-infarction left ventricular remodelling and heart failure.

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Section: Mirna and Left Ventricular Remodellingmentioning

confidence: 87%

The relevance of microRNA in post-infarction left ventricular remodelling and heart failure

2019

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“…In the study, we found a key miR-27a-3p and its targeted Litaf might participate in the molecular mechanism of CIR. MiR-27a-3p has been identi ed to be implicated in several types of human malignancies, including thyroid cancer [38], breast cancer [39], gastric cancer [40] and esophageal cancer [41]. LITAF is a mediator of local and systemic in ammatory responses [42] and is locally upregulated in many in ammatory diseases, such as Crohn disease and ulcerative colitis [43].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-27a-3p Relives Inflammation and Neurologic Impairment after Cerebral Ischemia Reperfusion via Inhibiting LITAF and the TLR4/NF-κB Pathway

Luo¹,

Li²,

Li³

et al. 2020

Preprint

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Background: Cerebral ischemia reperfusion (CIR) affects microRNA (miR) expression and causes substantial inflammation. Here, we investigated the influence and underlying mechanism of miR-27-3p in rats with CIR.Methods: Cerebral ischemia reperfusion was built by tMCAO. Rats were randomly divided into Sham group, brain ischemic reperfusion (IR) group, brain ischemic reperfusion transfected with NC group, brain ischemic reperfusion transfected with miR-27a-3p mimic group, brain ischemic reperfusion transfected with miR-27a-3p inhibitor group and brain ischemic reperfusion transfected with miR-27a-3p mimic and Litaf mimic group. The relationship between miR-27a-3p and Litaf was verified via qRT-PCR and luciferase assays. The cellular distribution of Litaf was determined via double immunofluorescence. The effect of miR-27a-3p on the expression of Litaf, TLR4, NF-κB and IL-6 was evaluated using synthetic miR-27a-3p mimic and inhibitor. The level of Nissl’s body in each group was detected by Nissl’s staining. The infarct in each group was evaluated by TTC staining.Results: Firstly, BV treatment relieves cerebral infarction and decreases the levels of serum IL-1β, IL-6 and TNF-α. Through our previous study, we found key microRNA mR-27a-3p and its targeted gene Litaf might involve in the molecular mechanism of CIR. Then, the regulation between miR-27a-3p and Litaf was verified by the temporal miR-27a-3p and Litaf expression profiles and luciferase assay. Moreover, intracerebroventricular injection of the miR-27a-3p mimic significantly decreased the Litaf, TLR4, NF-κB and interleukin (IL)-6 levels and the double-labeled cell count 24 h post-surgery, whereas miR-27a-3p inhibitor reversed these effects. Furthermore, miR-27a-3p mimic could relive cerebral infarct and neurologic deficit after CIR. In addition, injection of miR-27a-3p mimic decreased neuronal damage induced by CIR.Conclusions: Increasing miR-27-3p levels protect against CIR by relieving inflammation, neuronal damage and neurologic deficit by inhibiting LITAF and the TLR4/NF-κB pathway.

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“…When miR-27a was silenced with the help of a specific CD105 inhibitor, the level was maintained within 10%. These data suggest that miR-27a participates in angiogenesis; however, further research is necessary to better understand its molecular mechanism of action [19].…”

Section: Proangigenic Properties Of Micrornamentioning

confidence: 96%

The role of microRNAs in angiogenesis

Bujak

Kopytko

Lubecka

et al. 2019

Pomeranian Journal of Life Sciences

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Angiogenesis is the process that leads to the formation of new blood vessels. Under physiological conditions it occurs, inter alia, during corpus luteum formation and in some stages of the menstrual cycle. However, angiogenesis plays an essential role in many pathological conditions, particularly cancer. New blood vessel formation provides cancer cells with oxygen and essential nutrients, which stimulates tumor growth and facilitates its metastasis. Increasing evidence indicates that angiogenesis is regulated by microRNAs (miRNAs), which are small non-coding RNA molecules of 19-25 nucleotides. The main function of miRNAs is post-transcriptional regulation of gene expression, which controls many key biological processes, including cell proliferation, differentiation and migration. Endothelial miRNAs, known as angiomiRs, are presumably involved in tumor development and angiogenesis through regulation of pro-and antiangiogenic factors. To date, the miRNAs that stimulate angiogenesis are:

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Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis

Cited by 30 publications

References 22 publications

The relevance of microRNA in post-infarction left ventricular remodelling and heart failure

The relevance of microRNA in post-infarction left ventricular remodelling and heart failure

MicroRNA-27a-3p Relives Inflammation and Neurologic Impairment after Cerebral Ischemia Reperfusion via Inhibiting LITAF and the TLR4/NF-κB Pathway

The role of microRNAs in angiogenesis

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