2006
DOI: 10.1159/000090265
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Effects of Mistletoe Extract on Murine Thymocytes in vivo and on Glucocorticoid-Induced Cell Count Reduction

Abstract: Background: Mistletoe extracts are widely used in cancer patients due to their cytostatic and immunomodulatory effects. Essential components include mistletoe lectins which act as biomodulators with proinflammatory and apoptosisinducing effects. This study investigates the acute and longterm effects of standardized mistletoe extract (Iscador® M spec 5 mg) on thymocyte subpopulations and peripheral T-cells using a murine (Balb/c) model. Materials and Methods: Using cell surface CD4/CD8 staining and flow cytomet… Show more

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“…In this experiment, large dose of dexamethasone has been administered. At present, the capacity of dexamethasone to induce thymus apoptosis has been confirmed [ 40 43 ]. According to the study on SIRS and MODS, thymus apoptosis or proliferation will cause immune function disorder [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…In this experiment, large dose of dexamethasone has been administered. At present, the capacity of dexamethasone to induce thymus apoptosis has been confirmed [ 40 43 ]. According to the study on SIRS and MODS, thymus apoptosis or proliferation will cause immune function disorder [ 44 ].…”
Section: Discussionmentioning
confidence: 99%