Effects of mitomycin-C on tear film, corneal biomechanics, and surface irregularity in mild to moderate myopic surface ablation: Preliminary results

Mohammadi, Seyed Farzad; Ashrafi, Elham; Norouzi, Nima; Abdolahinia, Tahereh; Mir-AbouTalebi, Mohsen; Jabbarvand, Mahmoud

doi:10.1016/j.jcrs.2013.10.043

Cited by 14 publications

(24 citation statements)

References 17 publications

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“…However, Pentacam measured a significant increase (nearly 2‐fold, P < .05) in SA and RMS of corneal higher order aberrations after PRK (Tables and ). The A‐E and E‐B interfaces showed a much lower change in coneal aberrations, which supports the minimal change in ocular aberrations after low to moderate myopia PRK . In fact, the data from A‐E and E‐B interfaces showed that corneal higher order aberrations were minimally affected by the surgery (Tables and ).…”

Section: Discussionsupporting

confidence: 62%

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OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy

Chandapura

Shetty

Shroff

et al. 2017

Journal of Biophotonics

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OCT (optical coherence tomography) of corneal layers was generated to analyze the remodeling of the epithelium and stroma after photorefractive keratectomy (PRK). Myopic PRK was performed in 15 patients. One eye underwent manual scraping of epithelium while the other was treated with Epi clear. Epi clear allowed a gentler removal of the epithelium compared to manual scraping. Scheimpflug (Pentacam, OCULUS Optikgerate Gmbh, Wetzlar, Germany) and OCT (RTVue, Optovue Inc., Fremont, California, USA) scans of the cornea were performed before and after PRK (3 months). The OCT scanner and Pentacam acquired 8 and 25 radial 2-D scans of the cornea, respectively. The results showed similar topographic changes on the anterior corneal surface between Scheimpflug and OCT imaging. The curvature of the underlying anterior surface of the stroma after PRK was similar to the anterior corneal surface (air-epithelium interface), when measured with OCT. Aberrometric changes were mostly similar between Scheimpflug and OCT. However, Scheimpflug imaging reported greater changes in spherical aberration and corneal higher order aberrations than OCT after PRK. This is the first study to quantify the curvatures of the stromal layers with OCT after PRK. New insights were gained, which could be useful for refinement of surgical ablation algorithms, refractive procedures and detection of ectasia.

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Section: Discussionsupporting

confidence: 62%

“…Spherical aberration was the most affected after PRK ( P < .05) . Using Scheimplfug corneal imaging, there was hardly any corneal aberrometric changes noted after PRK . Using Scheimpflug imaging, another study reported a significant increase in anterior corneal higher order aberrations (mean spherical equivalent was less than −4D) .…”

Section: Discussionmentioning

confidence: 98%

OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy

Chandapura

Shetty

Shroff

et al. 2017

Journal of Biophotonics

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“…It has been demonstrated that MMC application during the PRK procedure does not cause additional changes in biomechanical properties. 13,14 In a study by Wang et al 15 comparing SMILE and LASIK, CH values were significantly lower after SMILE. They found that the difference in CH was especially large when correcting myopia of -6.00 D or more.…”

Section: Discussionmentioning

confidence: 97%

“…7,10,13,14,15,16,17 Several studies have evaluated the changes in biomechanical properties resulting from laser-assisted in situ keratomileusis (LASIK) and PRK, which have been employed for many years to treat myopia, as well as the SMILE procedure, a more current treatment method. 7,10,13,14,15,16 Although there are studies comparing LASIK with PRK and with SMILE in terms of their effects on corneal biomechanical properties, 7,16,17 our study is the first to compare corneal biomechanical aspects of the SMILE and PRK procedures in the treatment of myopia. In the current study, CH and CRF were used to evaluate corneal biomechanical properties.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Changes in Corneal Biomechanical Properties after Photorefractive Keratectomy and Small Incision Lenticule Extraction

Yıldırım¹,

Olcucu²,

Basci³

et al. 2016

tjo

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Objectives:To compare the postoperative biomechanical properties of the cornea after photorefractive keratectomy (PRK) and small incision lenticule extraction (SMILE) in eyes with low and moderate myopia.Materials and Methods:We retrospectively examined 42 eyes of 23 patients undergoing PRK and 42 eyes of 22 patients undergoing SMILE for the correction of low and moderate myopia. Corneal hysteresis (CH) and corneal resistance factor (CRF) were measured with an Ocular Response Analyzer before and 6 months after surgery. We also investigated the relationship between these biomechanical changes and the amount of myopic correction.Results:In the PRK group, CH was 10.4±1.3 mmHg preoperatively and significantly decreased to 8.5±1.3 mmHg postoperatively. In the SMILE group, CH was 10.9±1.7 mmHg preoperatively and decreased to 8.4±1.5 mmHg postoperatively. CRF was significantly decreased from 10.8±1.1 mmHg to 7.4±1.5 mmHg in the PRK group whereas it was decreased from 11.1±1.5 mmHg to 7.9±1.6 mmHg in the SMILE group postoperatively. There was a significant correlation between the amount of myopic correction and changes in biomechanical properties after PRK (r=-0.29, p=0.045 for CH; r=-0.07, p=0.05 for CRF) and SMILE (r=-0.25, p=0.048 for CH; r=-0.37, p=0.011 for CRF).Conclusion:Both PRK and SMILE can affect the biomechanical strength of the cornea. SMILE resulted in larger biomechanical changes than PRK.

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“…In the early stages after an operation, ocular surface functions may be affected because of the cytotoxicity of this drug. Nevertheless, at a 6 month follow-up, the use of mitomycin C did not appear to contribute significantly to surface irregularities or tear-film dysfunction [ 30 , 32 , 33 ]. Therefore, in order to eliminate the influence of mitomycin C, the patients who had undergone trabeculectomy at lease 6 months were recruited.…”

Section: Discussionmentioning

confidence: 99%

Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy

et al. 2016

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PurposeThe aim of this study was to analyze dry eye disease (DED) in patients with functioning filtering blebs and to explore the relationship between the morphology of filtering blebs and ocular surface instability.MethodsThis was a cross-sectional, case-comparison study. Seventy glaucomatous patients (70 eyes) with functioning blebs who had undergone trabeculectomy more than 6 months prior (study group) and 35 control subjects (35 eyes) (control group) were included. All subjects completed an ocular symptom questionnaire that referred to the Shihpai Eye Study. Evaluation of meibomian gland obstruction, a tear film break-up time test (TFBUT), fluorescein corneal staining and a Schirmer’s tear test were then performed. Filtering bleb morphology was analyzed using Wuerzburg bleb classification scoring criteria in the study group. The presence of DED was defined as the concomitant presence of TFBUT <10 seconds and the presence of superficial punctate keratitis.ResultsThe patients with functioning blebs presented higher corneal staining scores (P = 0.012) and lower TFBUT values (P = 0.043) than the control group. DED was present in 28/70 patients in the study group and 6/35 patients in the control group (P = 0.018). More patients in the study group complained of dryness (P = 0.001), a gritty or sandy sensation (P < 0.001) and redness (P = 0.048). In the study group, the patients with DED were significantly different from the patients without DED in both TFBUT (P < 0.001) and corneal staining (P < 0.001). More patients in the DED group were likely to report dryness (P = 0.013) and watery or teary eyes (P = 0.012). The differences in meibomian gland obstruction scores between the study and the control group, the DED and the non-DED group were not significant (P = 0.105 and P = 0.077, respectively). The values for microcysts and bleb heights were significantly higher in the DED group (P = 0.040 and P = 0.011, respectively). A Spearman’s rank correlation showed that microcysts were positively correlated with corneal staining (r = 0.270, P = 0.024). Bleb height was negatively correlated with TFBUT (r = -0.299, P = 0.012) and positively correlated with corneal staining (r = 0.275, P = 0.021). The relationships between DED and microcysts and between DED and bleb height were significant (r = 0.247, P = 0.039 and r = 0.307, P = 0.010, respectively).ConclusionDED is relatively common in patients with functioning filtering blebs following trabeculectomy. In DED patients, dryness and watery are common symptoms. Microcysts and bleb height are related to ocular surface instability and DED.

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Effects of mitomycin-C on tear film, corneal biomechanics, and surface irregularity in mild to moderate myopic surface ablation: Preliminary results

Abstract: No author has a financial or proprietary interest in any material or method mentioned.

Cited by 14 publications

References 17 publications

OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy

OCT layered tomography of the cornea provides new insights on remodeling after photorefractive keratectomy

Comparison of Changes in Corneal Biomechanical Properties after Photorefractive Keratectomy and Small Incision Lenticule Extraction

Dry Eye Disease in Patients with Functioning Filtering Blebs after Trabeculectomy

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