Effects of MK-801 and Ethanol Combinations on Memory Consolidation in CD1 Mice: Involvement of GABAergic Mechanisms

Aversano, Marco; Ciamei, Alessandro; Cestari, Vincenzo; Passino, Enrica; Castellano, Claudio

doi:10.1006/nlme.2001.4029

Cited by 11 publications

(12 citation statements)

References 30 publications

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“…Although acetaldehyde was suggested to be involved in a number of ethanol's effects, it has never been tested for its potential amnesic properties. The present study shows that acetaldehyde dose-dependently decreased stepthrough latencies at a comparable level to ethanol (Castellano and Populin 1990;Aversano et al 2002). Such results clearly indicate that acetaldehyde impairs memory consolidation.…”

Section: Discussionsupporting

confidence: 65%

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Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects

et al. 2004

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The present results show that acetaldehyde induces sedative, hypnotic and amnesic effects, whereas it is devoid of stimulant and anxiolytic-like properties in C57BL/6J mice. However, the behavioral effects of acetaldehyde after intraperitoneal administration were apparent at very high brain concentrations. The present results also indicate that acetaldehyde is unlikely to be involved in the anxiolytic properties of ethanol in mice.

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Section: Discussionsupporting

confidence: 65%

“…Bernaerts and Tirelli 2003). In previous one-trial passive avoidance experiments, ethanol was shown to reduce the step-through latency when injected immediately after acquisition trials (Castellano and Populin 1990;Aversano et al 2002). These results indicate that ethanol impairs memory consolidation.…”

Section: Discussionmentioning

confidence: 66%

Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects

et al. 2004

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“…20,21,8) In the present study, it was found that (ϩ)MK-801 potentiated the effects of muscimol on the retention of spatial working memory. Similar results have also been reported; for instance, Aversano et al 22) reported that (ϩ)MK-801 potentiated the effect of ethanol on memory consolidation in the …”

Section: Discussionsupporting

confidence: 87%

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Saito

Okada

Ouwa

et al. 2010

Biological & Pharmaceutical Bulletin

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To clarify the interaction between hippocampal g g-aminobutyric acid (GABA) A receptor and N-methyl-Daspartate (NMDA) receptor in the retention of spatial working memory, the effects of muscimol, (؉)MK-801, cyclosporin A and combined use of these drugs were studied on the retention of spatial working memory in a delayed spatial win-shift (SWSh) task. Intrahippocampal injection of muscimol at a dose of 3 nmol/side caused a significant decrease in the number of correct choices and an increase in the number of across-phase errors. On the other hand, (؉)MK-801 showed no significant effect on the number of correct choices, across-phase errors and within-phase errors, even at a dose of 1.5 nmol/side; however, (؉)MK-801 1.5 nmol/side significantly potentiated the effect of muscimol observed at a dose of 3 nmol/side on the number of correct choices and across-phase errors. Cyclosporin A at a dose of 3 nmol/side, which showed no effect when used separately, significantly potentiated the effect of muscimol observed at a dose of 3 nmol/side. These results indicate that hippocampal NMDA receptors regulate the effect of spatial working memory induced by muscimol. In addition, calcineurin may be involved in muscimol-induced impairment of memory retention.

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“…However, some reports showed conflicting results. Aversano et al (2002) demonstrated that post-training administration of ethanol impaired memory consolidation in a one-trial inhibitory avoidance task. Prado de Carvalho et al (1978) showed that a near-lethal dose of ethanol did not affect memory consolidation of shuttle avoidance task and inhibitory avoidance task.…”

Section: Discussionmentioning

confidence: 99%

“…However, conflicting results are reported in animal studies. Administration of ethanol at post-training either enhances (Alkana and Parker, 1979;Melia et al, 1986;Prediger and Takahashi, 2003) or impairs (Aversano et al, 2002) learning. By contrast, little is known about the effect of ethanol on consolidated memories.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Enhances Reactivated Fear Memories

Nomura

Matsuki

2008

Neuropsychopharmacol

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Although ethanol has been shown to impair acquisition of memory, its effect on consolidated memories is not clear. Recent reports revealed that memory retrieval converted consolidated memory into a labile state and initiated the reconsolidation process. In the present study, we have demonstrated the effect of ethanol on reactivated fear memory. We used contextual fear conditioning where rats were conditioned with mild footshock, re-exposed to the training context for 2 min, immediately injected with ethanol or saline, and finally tested 48 h after re-exposure. Ethanol-treated groups demonstrated longer freezing and the effect lasted for 2 weeks. Reactivation is necessary for this effect. Injection of ethanol itself did not induce a fearful response. Reactivated and ethanol-treated rats exhibited longer freezing than non-reactivated controls, suggesting that ethanol does not inhibit the memory decline but facilitates the fear memory. Two minute re-exposures induced no or little extinction. The effect of ethanol was specific for 2-min reactivation, which induces reconsolidation. Moreover, we found that picrotoxin inhibited the memory enhancement that was produced by ethanol administered just after the reactivation. These studies demonstrate that ethanol enhances reactivated contextual fear memories via activation of GABA A receptors.

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Effects of MK-801 and Ethanol Combinations on Memory Consolidation in CD1 Mice: Involvement of GABAergic Mechanisms

Cited by 11 publications

References 30 publications

Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects

Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Ethanol Enhances Reactivated Fear Memories

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