Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice

Ciamei, Alessandro; Aversano, Marco; Cestari, Vincenzo; Castellano, Claudio

doi:10.1007/s002130000584

Cited by 39 publications

(26 citation statements)

References 26 publications

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“…We observed that tacrine and rivastigmine were also effective against the dizocilpine-induced learning impairments, in agreement with Csernansky's hypothesis. Moreover, the observation that direct application of nicotine alleviated the dizocilpine-induced learning deficits (Ciamei et al, 2001) is in line with such hypothesis.…”

Section: Discussionsupporting

confidence: 64%

Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Maurice

Meunier

Feng

et al. 2006

J Pharmacol Exp Ther

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In the present study, we examined the interaction of (Ϯ)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]-methyl]-1H-inden-1-one hydrochloride (donepezil), a potent cholinesterase inhibitor, with two additional therapeutically relevant targets, N-methyl-D-aspartate (NMDA) and 1 receptors. Donepezil blocked the responses of recombinant NMDA receptors expressed in Xenopus oocytes. The blockade was voltagedependent, suggesting a channel blocker mechanism of action, and was not competitive at either the L-glutamate or glycine binding sites. The low potency of donepezil (IC 50 ϭ 0.7-3 mM) suggests that NMDA receptor blockade does not contribute to the therapeutic actions of donepezil. Of potential therapeutic relevance, donepezil binds to the 1 receptor with high affinity (K i ϭ 14.6 nM) in an in vitro preparation (Neurosci Lett 260:5-8, 1999). Thus, we sought to determine whether an interaction with the 1 receptor may occur in vivo under physiologically relevant conditions by evaluating the 1 receptor dependence effects of donepezil in behavioral tasks. Donepezil showed antidepressant-like activity in the mouse-forced swimming test as did the 1 receptor agonist igmesine. This effect was not displayed by the other cholinesterase inhibitors, rivastigmine and tacrine. The donepezil and igmesine effects were blocked by preadministration of the 1 receptor antagonist N- [2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) and an in vivo antisense probe treatment. The memory-enhancing effect of donepezil was also investigated. All cholinesterase inhibitors attenuated dizocilpine-induced learning impairments. However, only the donepezil and igmesine effects were blocked by BD1047 or the antisense treatment. Therefore, donepezil behaved as an effective 1 receptor agonist on these behavioral responses, and an interaction of the drug with the 1 receptor must be considered in its pharmacological actions.

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Section: Discussionsupporting

confidence: 64%

Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Maurice

Meunier

Feng

et al. 2006

J Pharmacol Exp Ther

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“…Various paradigms have been developed to assess similar learning and memory, and attention functions in rodents and similar to what is seen in humans, nicotine has been shown to improve rodent deficits in these paradigms [105,106,107,108,109]. DMXBA improves monkey performance on a delayed matching to sample task, an effect that persists for 24 hours after drug administration [110].…”

Section: Dmxba As a Prototype Drugmentioning

confidence: 99%

Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men

Olincy

Stevens

2007

Biochemical Pharmacology

125

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Current antipsychotic treatments fail to fully address the range of symptoms of schizophrenia, particularly with respect to social and occupational dysfunctions. Recent work has highlighted the role of nicotinic in both cognitive and attentional deficits as well as deficient processing of repetitive sensory information. The predilection for schizophrenia patients to be extremely heavy cigarette smokers may be related to their attempt to compensate for a reduction in hippocampal α7 nicotinic cholinergic receptors by delivering exogenous ligand to the remaining receptors. Studies in rodent models of both learning and memory deficits and deficits in sensory inhibition have confirmed a role for α7 subtype of the nicotinic cholinergic receptors in these processes. Rodent studies also demonstrated the efficacy of a selective partial α7 nicotinic agonist, DMXBA, to improve these deficits. Subsequent human clinical trials demonstrated improved sensory inhibition in 12 schizophrenia patients and showed improvement in several subtests of the RBANS learning and memory assessment instrument. These data suggest that therapeutic agents selected for α7 nicotinic activity may have utility in treating certain symptoms of schizophrenia. KeywordsSchizophrenia; nicotinic receptors; DMXBA; P50 auditory evoked potential; cognitive deficits; nicotine Although the positive symptoms such as hallucinations and delusions of schizophrenia are partially treated with the available antipsychotic medications, social and occupational dysfunction remains a major issue in treating this disorder. Cognitive deficits have been identified as more closely related to ability to adequately function [1]. In the search for new and more effective therapeutic agents for schizophrenia, recent attention has turned the nicotinic cholinergic receptors system. α7 and P50 Auditory GatingPeople with schizophrenia, in addition to the cardinal symptoms of hallucinations and delusions, suffer from the inability to focus attention. This may stem from being overwhelmed

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“…Nicotinic acetylcholine receptor (nAChR) agonists are among several classes of cognitiveenhancing agents under investigation for treatment of cognitive deficits associated with schizophrenia (Levin and Rezvani 2002). Nicotine improves memory in animals (Arendash et al 1995;Ciamei et al 2001;Levin and Simon 1998) and improves attention, learning, and memory in healthy adults (Ernst et al 2001;Lawrence et al 2002;Mancuso et al 1999;McClernon et al 2003;Rusted et al 1998;Rusted et al 2005;Levin et al 2006). In addition, nicotine has demonstrated benefits in these domains in patients with Alzheimer's disease (Wilson et al 1995), age-associated memory impairment (White and Levin 2004), attention deficit hyperactivity disorder (Poltavski and Petros 2006), and depression .…”

Section: Introductionmentioning

confidence: 98%

Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia

et al. 2008

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These data suggest that nicotine improves novelty detection in non-smokers, an effect that may be more pronounced in non-smokers with schizophrenia. Because memory deficits are associated with functional impairment in schizophrenia and because impaired novelty detection has been linked to the positive symptoms of schizophrenia, study of the effects of chronic nicotinic agonist treatment on novelty detection may be warranted.

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Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice

Abstract: In conclusion, from the present research, it is evident that NMDA glutamate and nicotinic acetylcholine receptor systems interact in modulating memory consolidation in CD I mice.

Cited by 39 publications

References 26 publications

Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men

Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia

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Effects of MK-801 and nicotine combinations on memory consolidation in CD1 mice

Abstract: In conclusion, from the present research, it is evident that NMDA glutamate and nicotinic acetylcholine receptor systems interact in modulating memory consolidation in CD I mice.

Cited by 39 publications

References 26 publications

Interaction with σ1 Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Interaction with σ1 Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men

Effects of transdermal nicotine on episodic memory in non-smokers with and without schizophrenia

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Product

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Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil

Interaction with σ₁ Protein, but Not N-Methyl-d-aspartate Receptor, Is Involved in the Pharmacological Activity of Donepezil