Effects of moderate endurance exercise on calcium, parathyroid hormone, and markers of bone metabolism in young women

Abstract

We investigated the short-term (1 hour-3 days) effects of a 45 minute run on calcium, parathyroid hormone, the carboxyterminal propeptide of type I procollagen (PICP), and the immunoactive carboxyterminal telopeptide of type I collagen in serum (ICTP) in young females. Fourteen healthy young women, aged 25.2 +/- 0.6 years (mean +/- SEM) with regular menstruations, participated. The test was outdoor jogging for 45 minutes at an intensity of 50% of VO2 max. Blood samples were collected 15 minutes before the test and 1, 24, and 72 hours after the test. The measured values were adjusted for changes in plasma volume. A significant decrease of ionized calcium was observed at 1 hour (P < 0.001) and 72 hours (P < 0.05) and a significant increase of parathyroid hormone (PTH) was noted 24 (P < 0.01) and 72 hours (P < 0.05) after the test. A significant decrease of PICP at 1 hour (P < 0.05) was followed by an increase after 24 (P < 0.01) and 72 hours (P < 0.001) and a significant increase in ICTP was noted at 24 and 72 hours (P < 0.05). A strong positive correlation was found between serum levels of PICP and ICTP (r = 0. 55-0.84; P < 0.05) throughout the experiment. In conclusion, young females showed biochemical signs of increased bone collagen turnover and altered homeostasis of calcium and PTH after a single bout of moderate endurance exercise.

The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise

“…This is in contrast to previous studies of high-intensity endurance exercise (29,38) and some (61) but not all (56, 62) studies of low-to moderate-intensity exercise. The decrease in daytime OC concentrations is associated with the nocturnal increase in cortisol that precedes it (30, 45), although we observed no decrease in OC with exercise at 75% V O 2max despite higher cortisol concentrations compared with 55% and 65% V O 2max .…”

Effect of impact exercise on bone metabolism

“…Previous experimental studies have suggested that mechanical loading and PTH have an interactive effect on bone turnover [32] and this interaction may occur during the mechanotransduction [33]. In clinical studies, short bouts of exercise have been found to stimulate transient PTH secretion [14,15,34,35]. Contrary to this, we found a significant decrease in serum PTH in the exercise group compared to the control group at 6 and 12 months while BMD increased and favorable geometric changes occurred.…”

Impact of strenuous exercise on bone metabolism parameters among elderly

“…Similar to the current study, Thorsen et al, [29] In contrast, Kristoffersson et al, [30] found increased iCa levels after short term maximal work, without significant changes in the serum PTH levels.…”