Effects of Moderate Intensity Physical Training in Neonatal Alloxan- Administered Rats

Ribeiro, Carla; Mota, Clécia Soares de Alencar; Voltarelli, Fabrí­cio Azevedo; Araújo, Michel Barbosa de; Botezelli, José Diego

doi:10.4172/2155-6156.1000107

Cited by 21 publications

(17 citation statements)

References 27 publications

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“…These findings are consistent with Ribeiro et al [38], who conducted a study using a neonatal alloxan model that demonstrated similar lactacidemia among groups. The response of sedentary animals to the test could be interpreted as moderate intensity with a predominance of aerobic metabolism, given the values of lactate that were achieved and the moderate intensity at the start of the training program.…”

Section: Discussionsupporting

confidence: 92%

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

et al. 2012

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BackgroundType 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by insulin resistance. Its development is directly connected with the inability of insulin to exert its action, not just on carbohydrate metabolism but also on primarily on lipid metabolism. The present study aimed to compare the effects of continuous, intermittent, and strength training on serum and tissue variables on the lipid metabolism of alloxan rats.MethodsWistar rats were divided into eight groups: sedentary alloxan (SA), sedentary control (SC), continuous training alloxan (CA), intermittent training alloxan (IA), strength training alloxan (StA), continuous training control (CC), intermittent training control (IC) and strength training control (StC). Alloxan (250 mg/kg bw) was injected into neonatal rats at 6 days of age. The continuous training protocol consisted of 12 weeks of swimming training for 1 uninterrupted hour / day, five days/ week, supporting a load that was 5% bw. The intermittent training protocol consisted of 12 weeks of swimming training with 30 s of activity interrupted by 30 s of rest, for a total of 20 min/day, five days/ week, supporting a load that was 15% bw. The strength-training protocol consisted of 12 weeks of training, five days/week with 4 sets of 10 jumps in water with 1 min rest between sets, supporting a load that was a 50% bw.ResultsAt 28 days, the alloxan animals exhibited higher insulin resistance as measured by the disappearance of glucose serum (% Kitt/min) during the ITT. At 120 days, the sedentary alloxan animals showed higher FFA values than continuous and intermittent training alloxan. In addition, the alloxan animals that underwent intermittent and strength training showed lower FFA values compared to the corresponding controls. The continuous training protocol was less effective than the strength training protocol for reducing the levels of total cholesterol in the alloxan animals. Serum total lipid values revealed that intermittent training increased serum levels in alloxan animalsConclusionThus, it was concluded that physical training at different intensities of effort is of great importance in attenuation and control of changes in the lipid metabolism in alloxan animals.

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Section: Discussionsupporting

confidence: 92%

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

et al. 2012

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“…The underlying causes of DM constitute either deficiency in insulin secretion or resistance to insulin action or both [19].…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic potential of <i>Balanites Aegyptiaca</i> kernel, flesh and their combination against streptozotocin-induced hyperglycemia in male rats

Althobaiti¹,

Zeid²

2019

Trop. J. Pharm Res

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Purpose: To investigate the antidiabetic effect of Balanites aegyptiaca fruit kernel, flesh and their mixture on streptozocin (STZ)-induced diabetes in male rats. Methods: Six-week-old male Wistar rats were divided into nine groups: (1) control; (2) kernel; (3) flesh; (4) kernel + flesh; (5) STZ; (6) STZ + kernel; (7) STZ + flesh; (8) STZ + (kernel + flesh) and (9) STZ + metformin. Body weight changes, fasting blood glucose and serum insulin were assessed. Haematoxylin and Eosin (H & E) stained pancreas sections were examined microscopically for the number and status of β cells. Results: Administration of Balanites aegyptiaca kernel, flesh and their mixture significantly increased rat body weight compared to STZ-treated rats. In addition, the hypoglycemic effect of kernel, flesh and their mixture was noticed. In STZ-treated rats, administration of Balanites aegyptiaca kernel and kernel + flesh mixture significantly increased serum insulin (p < 0.05). Histopathological examination revealed a marked increase in the islets cell population with cellular activation, with superior effect in STZ + kernel group and STZ + (kernel + flesh) group. Conclusion: Balanites aegyptiaca showed a hypoglycemic effect which is comparable to metformin action. Further studies are required to determine its suitability as an anti-diabetic agent in humans

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“…Type-1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets [54] of Langerhans in the pancreas leading to insulin deficiency [55]. In early days people suffering from Type-1 Diabetes usually ended with death, but with the advent of insulin now people are able to manage this disease [56].…”

Section: Type-1 Diabetesmentioning

confidence: 99%

Role of Diabetes in prevalence of Tuberculosis

Siddiqui¹

2012

J Diabetes Metab

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Tuberculosis is a lethal disease caused by Mycobacterium tuberculosis. The Mycobacterium initially infects lungs. If the infection spreads beyond the lungs, the symptoms will depend upon the individual organs. Diabetes is a type of metabolic disease in which a person has increased blood sugar level. It's because the body does not produce enough insulin or the cells inside the body do not respond to the insulin that is produced. Diabetics have a three to five time's higher risk of developing tuberculosis (TB) than those without diabetes disease. Diabetes mellitus is an important risk factor for tuberculosis and may affect disease treatment and also the response. Additionally tuberculosis may induce glucose intolerance and worsen the glycaemic control in people with diabetes. The main aim of this Review is to evaluate the epidemiology of diabetes mellitus and tuberculosis disease, the effect of diabetes mellitus on tuberculosis and vice versa.  When the immune system of a patient with dormant TB is weakened, the TB can become active (reactivate) and cause infection in lungs or any other parts of the body. The risk factors for acquiring TB include close-contact situations, alcohol, drug abuse and certain diseases (examples include diabetes, cancer, and HIV) and occupations (for example, health-care workers). The common signs and symptoms of TB include fatigue, fever, weight loss, coughing, and night sweats. The diagnosis of TB involves skin tests, chest X-rays, sputum analysis (smear and culture), and PCR tests to detect the genetic material of the causative bacteria or causative agent [12]. Inactive tuberculosis may be treated with an isoniazid (INH), antibiotic, in order to prevent the TB infection from becoming active. Active TB is usually treated, successfully, with INH in combination with one or more of several drugs, including rifampin (Rifadin), ethambutol (Myambutol), pyrazinamide, and streptomycin [13].

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Effects of Moderate Intensity Physical Training in Neonatal Alloxan- Administered Rats

Cited by 21 publications

References 27 publications

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan

Antidiabetic potential of <i>Balanites Aegyptiaca</i> kernel, flesh and their combination against streptozotocin-induced hyperglycemia in male rats

Role of Diabetes in prevalence of Tuberculosis

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