Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats

Wiley, Jenny L.; Balster, Robert L.

doi:10.1016/j.lfs.2003.11.027

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…First, both drug classes inhibit neurotransmission; NMDAR antagonists do so by blocking sodium and calcium influx into neurons, whereas benzodiazepines facilitate chloride ion entry (Haefely, Martin, Richards, & Schoch, 1993; Lodge & Johnson, 1990; Twyman, Rogers, & Macdonald, 1989). Second, NMDAR antagonists and benzodiazepines produce depressant actions on the central nervous system that include anticonvulsant and anxiolytic effects and muscle relaxation (Wiley & Balster, 2004; Willetts, Balster, & Leander, 1990). Whole-cell recordings from hippocampal neurons have shown that BZDs, like NMDAR antagonists, reduce NMDAR-mediated currents in hippocampal neurons (Van Sickle, Cox, Schak, Greenfield, & Tietz, 2002).…”

Section: Discussionmentioning

confidence: 99%

Chlordiazepoxide interactions with scopolamine and dizocilpine: Novel cooperative and antagonistic effects on spatial learning.

Padlubnaya¹,

Galizio²,

Pitts³

et al. 2005

Behavioral Neuroscience

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The authors investigated the effects on spatial behavior of coadministrations of a benzodiazepine, chlordiazepoxide (CDP), with a noncompetitive N-methyl-d-aspartate receptor antagonist (NMDAR), dizocilpine (DZP), and a muscarinic cholinergic receptor antagonist, scopolamine (SCP). Rats solved the Morris swim task in 2 settings; 1 in which a hidden escape platform was always in the same location (performance) and a 2nd in which the platform had been moved to a different location (acquisition) for repeated daily sessions. CDP (3.0 mg/kg) administered alone did not disrupt escape latencies or swim path accuracies. SCP and DZP each impaired acquisition and performance in a dose-dependent manner. CDP coadministered with 0.3 mg/kg SCP impaired escape only in the acquisition setting and when coadministered with 1.0 mg/kg SCP selectively exacerbated the escape impairment in the acquisition setting. CDP ameliorated deleterious effects of DZP in both settings.

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Section: Discussionmentioning

confidence: 99%

Chlordiazepoxide interactions with scopolamine and dizocilpine: Novel cooperative and antagonistic effects on spatial learning.

Padlubnaya¹,

Galizio²,

Pitts³

et al. 2005

Behavioral Neuroscience

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Short-term and long-term effects of diazepam on the memory for discrimination and generalization of scopolamine

et al. 2017

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Benzodiazepines are among the most widely prescribed and misused psychopharmaceutical drugs. Although they are well-tolerated, they are also capable of producing amnestic effects similar to those observed after pharmacological or organic cholinergic dysfunction. To date, the effect of benzodiazepine diazepam on the memory for discrimination of anticholinergic drugs has not been reported. The aim of the present study was to analyze the immediate and long-term effects of diazepam on a drug discrimination task with scopolamine. Male Wistar rats were trained to discriminate between scopolamine and saline administration using a two-lever discrimination task. Once discrimination was acquired, the subjects were divided into three independent groups, (1) control, (2) diazepam, and (3) diazepam chronic administration (10 days). Subsequently, generalization curves for scopolamine were obtained. Additionally, the diazepam and control groups were revaluated after 90 days without having been given any other treatment. The results showed that diazepam produced a significant reduction in the generalization gradient for scopolamine, indicating an impairment of discrimination. The negative effect of diazepam persisted even 90 days after drug had been administered. Meanwhile, the previous administration of diazepam for 10 days totally abated the generalization curve and the general performance of the subjects. The results suggest that diazepam affects memory for the stimulus discrimination of anticholinergic drugs and does so persistently, which could be an important consideration during the treatment of amnesic patients with benzodiazepines.

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Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats

Cited by 2 publications

References 36 publications

Chlordiazepoxide interactions with scopolamine and dizocilpine: Novel cooperative and antagonistic effects on spatial learning.

Chlordiazepoxide interactions with scopolamine and dizocilpine: Novel cooperative and antagonistic effects on spatial learning.

Short-term and long-term effects of diazepam on the memory for discrimination and generalization of scopolamine

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