Effects of monensin on volatile fatty acid metabolism in periparturient dairy cows using compartmental analysis

Markantonatos, X.; Aharoni, Y.; Richardson, L. F.; Varga, G.A.

doi:10.1016/j.anifeedsci.2009.05.007

Cited by 8 publications

(18 citation statements)

References 35 publications

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“…In turn, each time point after the labeled glucose injection was corrected for the background (sample taken 10 min before labeled glucose injection) enrichment. The APE, which represents the enrichment of the glucose molecule with 13 C above background, was then used to calculate enriched glucose concentration as well as plasma glucose parameters, such as plasma glucose pool size, glucose dispersion volume, and glucose clearance rate at a given time t. 13 C-Propionate isotopic abundance was calculated as described by Markantonatos et al (2009). Isotopic abundances of labeled propionate were expressed as tracer/(tracer + tracee) (TTR) and corrected for skewness as described by Wolfe (1992).…”

Section: Glucose Kineticsmentioning

confidence: 99%

“…A 4-compartment model was constructed with the assumptions (a) cows were in a steady-state condition with respect to ruminal propionate and plasma glucose; (b) no re-entry of label back into the rumen (France and Dijkstra, 2005); (c) no exchange of any single labeled 13 C or other compounds during the kinetics studies (Markantonatos et al, 2009); (d) propionate acted as a single pool (it does not exchange 13 C with the other major VFA; i.e., acetate and butyrate; Bergman et al, 1965;Leng and Leonard, 1965); and (e) 1 mol of glucose is formed from 2 mol of propionate, and all carbon atoms within these 2 mol of propionate appear in the formed glucose (Leng and Leonard, 1965). The model described the kinetics of both labeled propionate infused in the rumen and labeled glucose injected through the jugular vein following bolus infusion of labeled propionate and instant injection of labeled glucose at t 0 .…”

Section: Description Of the Propionate-glucose Modelmentioning

confidence: 99%

“…Net production rate of ruminal propionate available to glucose production (adapted from Markantonatos et al, 2009). tion to GlP (PrContrGl; %), and propionate conversion to glucose (PrConvGl; %).…”

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confidence: 99%

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Effects of monensin on glucose metabolism in transition dairy cows

Markantonatos

Varga

2017

Journal of Dairy Science

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Eight multiparous periparturient Holstein cows fitted with ruminal cannula were used in a split plot design to evaluate the effects of monensin on plasma glucose metabolism. Diets were top-dressed daily with 0 mg/cow of monensin (control) or 300 mg/cow of monensin (MON) both pre- and postpartum. Plasma glucose kinetic parameters on d -13 ± 2.0 and 19 ± 1.6 relative to parturition were determined by using stable isotopes. Na-1-C-Propionate (labeled propionate) was infused into the rumen to measure glucose synthesis originating from ruminal propionate, and U-C-glucose (labeled glucose) was injected into the jugular vein to determine total glucose kinetics. A sampling period of 480 min following labeled glucose injection was implemented. A compartmental analysis was employed to determine steady state glucose kinetic parameters. To develop a steady state glucose model, the Windows version of SAAM software (WinSAAM) was used. A 4-compartment model was adequate to comprehensively describe plasma glucose metabolism. The main model compartments consisted of propionate and plasma glucose. The time frame of the 480-min sampling period post-tracer glucose infusion allowed accurate quantification of glucose metabolism. The model estimated that glucose input from sources other than ruminal propionate decreased with MON, from 2.26 to 1.09 g/min postpartum. Gluconeogenesis, expressed as the propionate contribution to the plasma glucose pool, increased in cows fed MON (22 vs. 31%), whereas glucose oxidation, expressed as the glucose disposal rate, significantly decreased (1.67 vs. 0.92 g/min). In conclusion, MON may improve the energy status of transition cows by (1) improving the efficiency of propionate to produce glucose and (2) decreasing glucose oxidation in body tissues.

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Section: Glucose Kineticsmentioning

confidence: 99%

Section: Description Of the Propionate-glucose Modelmentioning

confidence: 99%

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Effects of monensin on glucose metabolism in transition dairy cows

Markantonatos

Varga

2017

Journal of Dairy Science

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“…However, there were no differences between the groups (p > 0.05) (Figure 3). Brown and Hogue (13) and Aderinboye et al (15) working with goats, Markantonatos et al (16) working with dairy cows, and Lima et al (5) working with sheep also found no significant variations in pH between groups of animals receiving monensin supplementation or the control animals. This pH stability is probably attributed to the steady concentration of volatile fatty acids in the rumen during the experiment.…”

Section: Resultsmentioning

confidence: 95%

“…This change in the VFAs proportion was also observed by Brown and Hogue (13) , Mousa (14) , and Aderinboye et al (15) in dairy goats and young and confined male goats receiving monensin in diets at concentrations known to improve feed efficiency. Analyzing the effect of this ionophore on dairy cows during the transition period, Markantonatos et al (16) observed that a reduction in the acetate/propionate ratio occurred because of the decreased production of acetate. These findings might be explained by the action of this ionophore, which modifies the bacterial population in the rumen and selectively inhibits Gram-positive bacteria while preserving the Gramnegative bacteria.…”

Section: Resultsmentioning

confidence: 99%

Effects of Dietary Sodium Monensin on the Metabolic and Hormonal Profiles of Dairy Goats During the Peripartum Period

et al. 2018

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This study aimed to investigate the energetic and hormonal profiles of dairy goats fed diets supplemented with monensin during the peripartum period. Eleven pregnant Saanen goats were subdivided into two random groups, a control group (GC) and the monensin group (MG). The MG group received 40 mg sodium monensin per animal per day for 15 days before partum and throughout the subsequent experimental period. Clinical observations and sample collection were performed at 30, 15, and 7 days before birth; on the day of partum; and at 5, 15, and 30 days after birth. The following biochemical and hormonal profile variables analyzed were: cholesterol, triglycerides, glucose, fructosamine, non-esterified fatty acids (NEFAs) and β-hydroxybutyrate (BHB), cortisol, and insulin. The ruminal fluid pH, chloride content, and volatile fatty acids were also measured. Statistical analysis of the data was performed using repeated measures ANOVA (p < 0.05) and Pearson's correlation. At partum, the MG group had lower values of NEFAs and lower acetate/propionate ratio. MG had higher triglycerides during the entire experiment period. The administration of monensin generated benefits in terms of energy parameters, improving the metabolic status of the dairy goats during peripartum.

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Effects of Supplementation of Chromium, Monensin and Their Combination on Some Blood Metabolites, Liver Enzymes and Insulin in Close-Up Holstein Dairy Cows

Ghandehari¹,

Khodaei-Motlagh²,

Kazemi-Bonchenari³

2018

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In the present study, 30 multiparous close-up Holstein cows (average parity 3.8) were allocated in a completely randomized design with four treatments to evaluate the effect of chromium, monensin and their combination on blood metabolites and liver enzymes. Experimental treatments were: 1) control (no supplementation) 2) monensin (400 mg/d/h) 3) Chromium (0.03 mg/BW0.75) 4) combination of both supplements with similar dosages. Liver enzymes (AST and ALP) as well as the blood metabolites (glucose, BHBA, total protein, albumin) and insulin were evaluated. The results showed that blood parameters except that BHBA, glucose did not affect by treatment (p>0.05). BHBA concentrations in cows received chromium and its combination with monensin reduced before calving (p<0/05). Glucose concentrations was increased in cows supplemented with monensin (p<0/05). In conclusion, the results revealed that dietary combined supplementation of monensin and chromium may have positive affect on metabolism and energy status of multiparous close-up Holstein cows.

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Effects of monensin on volatile fatty acid metabolism in periparturient dairy cows using compartmental analysis

Cited by 8 publications

References 35 publications

Effects of monensin on glucose metabolism in transition dairy cows

Effects of monensin on glucose metabolism in transition dairy cows

Effects of Dietary Sodium Monensin on the Metabolic and Hormonal Profiles of Dairy Goats During the Peripartum Period

Effects of Supplementation of Chromium, Monensin and Their Combination on Some Blood Metabolites, Liver Enzymes and Insulin in Close-Up Holstein Dairy Cows

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