Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows

Dieleman, S.J.; Bevers, M.M.

doi:10.1530/jrf.0.0810533

Cited by 137 publications

(79 citation statements)

References 20 publications

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“…17 We used rabbit antiserum raised against ovine LH, g radioiodinated bovine LH-7981 as prepared for a bovine assay, 18 and canine pituitary standard LER 1685-1. h The intraassay and interassay CVs for concentrations above 0.5 mg/L were 2.3 and 10.5%, respectively. The limit of quantitation was 0.3 mg/L.…”

Section: Hormone Determinationsmentioning

confidence: 99%

Adenohypophyseal Function in Dogs with Primary Hypothyroidism and Nonthyroidal Illness

Diaz-Espineira¹,

Mol²,

Rijnberk³

et al. 2009

Veterinary Internal Medicne

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Background: A recent study of dogs with induced primary hypothyroidism (PH) demonstrated that thyroid hormone deficiency leads to loss of thyrotropin (TSH) hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with large vacuolated ''thyroid deficiency'' cells that double-stained for growth hormone (GH) and TSH, indicative of transdifferentiation of somatotropes to thyrosomatropes.Hypothesis: Similar functional changes in adenohypophyseal function occur in dogs with spontaneous PH as do in dogs with induced PH, but not in dogs with nonthyroidal illness (NTI).Animals: Fourteen dogs with spontaneous PH and 13 dogs with NTI. Methods: Adenohypophyseal function was investigated by combined intravenous administration of 4 hypophysiotropic releasing hormones (4RH test), followed by measurement of plasma concentrations of ACTH, GH, luteinizing hormone (LH), prolactin (PRL), and TSH. In the PH dogs this test was repeated after 4 and 12 weeks of thyroxine treatment.Results: In 6 PH dogs, the basal TSH concentration was within the reference range. In the PH dogs, the TSH concentrations did not increase with the 4RH test. However, TSH concentrations increased significantly in the NTI dogs. Basal and stimulated GH and PRL concentrations indicated reversible hypersomatotropism and hyperprolactinemia in the PH dogs, but not in the NTI dogs. Basal and stimulated LH and ACTH concentrations did not differ between groups.Conclusions and Clinical Importance: Dogs with spontaneous PH hypersecrete GH but have little or no TSH hypersecretion. Development of hyperprolactinemia (and possible galactorrhea) in dogs with PH seems to occur only in sexually intact bitches. In this group of dogs with NTI, basal and stimulated plasma adenohypophyseal hormone concentrations were not altered.

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Section: Hormone Determinationsmentioning

confidence: 99%

Adenohypophyseal Function in Dogs with Primary Hypothyroidism and Nonthyroidal Illness

Diaz-Espineira¹,

Mol²,

Rijnberk³

et al. 2009

Veterinary Internal Medicne

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“…A rabbit antiserum raised against ovine LH (CSU-204, kindly supplied by G.D. Niswender, Colorado State University, CO, USA), radio-iodinated bovine LH-7981 as prepared for our bovine LH assay [31], and canine pituitary standard LER 1685-1 (a gift of Dr. L.E. Reichert, Albany Medical College, NY, USA) were used in this assay.…”

Section: Hormone Determinationsmentioning

confidence: 99%

Adenohypophyseal function in bitches treated with medroxyprogesterone acetate

Beijerink

Bhatti

Okkens

et al. 2007

Domestic Animal Endocrinology

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The aim of this study was to investigate the effects of treatment with medroxyprogesterone acetate (MPA) on canine adenohypophyseal function. Five Beagle bitches were treated with MPA (10 mg/kg, every 4 weeks) and their adenohypophyseal function was assessed in a combined adenohypophyseal function test. Four hypophysiotropic hormones (CRH, GHRH, GnRH, and TRH) were administered before and 2, 5, 8, and 11 months after the start of MPA treatment, and blood samples for determination of the plasma concentrations of ACTH, cortisol, GH, IGF-1, LH, FSH, prolactin, ␣-MSH, and TSH were collected at −15, 0, 5, 10, 20, 30, and 45 min after suprapituitary stimulation.MPA successfully prevented the occurrence of estrus, ovulation, and a subsequent luteal phase. MPA treatment did not affect basal and GnRH-induced plasma LH concentrations. The basal plasma FSH concentration was significantly higher at 2 months after the start of MPA treatment than before or at 5, 8, and 11 months after the start of treatment. The maximal FSH increment and the AUC for N.J. Beijerink et al. / Domestic Animal Endocrinology xxx (2006) xxx-xxxmonths of MPA treatment. Differences in mean basal plasma GH concentrations before and during treatment were not significant, but MPA treatment resulted in significantly elevated basal plasma IGF-1 concentrations at 8 and 11 months. MPA treatment did not affect basal and stimulated plasma ACTH concentrations, with the exception of a decreased AUC for ACTH at 11 months. In contrast, the maximal cortisol increment and the AUC for cortisol after suprapituitary stimulation were significantly lower during MPA treatment than prior to treatment. MPA treatment did not affect basal plasma concentrations of prolactin, TSH, and ␣-MSH, with the exception of slightly increased basal plasma TSH concentrations at 8 months of treatment. MPA treatment did not affect TRH-induced plasma concentrations of prolactin and TSH.In conclusion, the effects of chronic MPA treatment on adenohypophyseal function included increased FSH secretion, unaffected LH secretion, activation of the mammary GH-induced IGF-I secretion, slightly activated TSH secretion, suppression of the hypothalamic-pituitary-adrenocortical axis, and unaffected secretion of prolactin and ␣-MSH.

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“…DHT levels were estimated on the basis of the cross reactivity of the antibody for T with DHT (see below). For methods and evaluation of the radioimmunoassays used, see Dieleman et al (1983) for testosterone, and Dieleman and Bevers (1987) for 17h-estradiol.…”

Section: Blood Sampling and Radioimmunoassaymentioning

confidence: 99%

The hormonal control of begging and early aggressive behavior: Experiments in black-headed gull chicks

Groothuis

Ros

2005

Hormones and Behavior

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Effects of monoclonal antibody against PMSG administered shortly after the preovulatory LH surge on time and number of ovulations in PMSG/PG-treated cows

Cited by 137 publications

References 20 publications

Adenohypophyseal Function in Dogs with Primary Hypothyroidism and Nonthyroidal Illness

Adenohypophyseal Function in Dogs with Primary Hypothyroidism and Nonthyroidal Illness

Adenohypophyseal function in bitches treated with medroxyprogesterone acetate

The hormonal control of begging and early aggressive behavior: Experiments in black-headed gull chicks

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