Effects of monocyte‐macrophage colony‐stimulating factor (M‐CSF) on <i>in vitro</i> erythropoiesis of marrow progenitor cells from patients with renal anemia

Kawano, Yoshifumi; Takaue, Yoichi; Murata, Jun; Kawashima, Shuh; Kimura, Fumihiko; Motoyoshi, Kazuo; Abe, Takanori; Sato, Junko; Hirao, Atsushi; Saito, Shinichi; Suzue, Takeshi; Kuroda, Yasuhiro

doi:10.1111/j.1600-0609.1995.tb00205.x

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…In addition, previous study showed that M-CSF inhibits the growth of erythroid progenitor cells in patients with renal failure who were undergoing hemodialysis, probably by reducing their sensitivity to erythropoietin [40]. Our finding was consistent with this conclusion.…”

Section: Discussionsupporting

confidence: 92%

Association of plasma macrophage colony-stimulating factor with cardiovascular morbidity and all-cause mortality in chronic hemodialysis patients

et al. 2019

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Background Cardiovascular disease (CVD) events are the main cause of death in long-term hemodialysis (HD) patients. Macrophage colony- stimulating factor (M-CSF) is actively involved in the formation of atherosclerosis and causes plaque instability, thrombosis and the development of acute coronary syndromes. However, little information is available on the role of M-CSF in HD patients. We aimed to investigate the association between plasma M-CSF levels and CVD events as well as all-cause mortality in patients undergoing long-term HD. Methods Fifty two HD patients and 8 healthy controls were recruited in this study. HD patients were followed up from September 2014 to May 2017. The primary end point was CVD event, the secondary outcome was death from any cause. Patients were divided into two groups with low and high M-CSF levels based on the optimal cut-off value determined by the ROC curve. Cox regression analyses were used to assess the predictive value of plasma M-CSF for CVD events and all-cause mortality in HD patients. We tested the levels of plasma M-CSF and other inflammatory cytokines in surviving HD patients using ELISA or CBA kit. Results The average plasma level of M-CSF in 52 patients was approximately twice that of healthy controls (992.4 vs. 427.2 pg/mL; p < 0.05). During 32 months of follow-up, 26 patients (50.0%) had at least one CVD event and 8 patients (15.4%) died. The mean plasma M-CSF concentration increased in survivors after follow-up compared to that detected at baseline (1277.8 ± 693.3 vs. 997.2 ± 417.4 pg/mL; p < 0.05). Multivariate Cox regression analysis showed that plasma M-CSF is an independent risk factor for CVD events in HD patients ( p < 0.05). In the Cox regression model after adjusting for gender and age, high M-CSF levels were related to an increased risk of all-cause death ( p < 0.05). We also found that M-CSF levels were positively correlated with IL-6 and IL-18 levels (both p < 0.05), which are the major pathogentic cytokines that contribute to HD-related CVD events. Conclusion M-CSF is a prognostic factor for CVD events and all-cause mortality in HD patients.

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Section: Discussionsupporting

confidence: 92%

Association of plasma macrophage colony-stimulating factor with cardiovascular morbidity and all-cause mortality in chronic hemodialysis patients

et al. 2019

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In vitro expansion of human cord blood CD36+ erythroid progenitors: Temporal changes in gene and protein expression

Scicchitano

McFarland

Tierney

et al. 2003

Experimental Hematology

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Role of the macrophage in erythropoiesis

Sadahira

Mori

1999

Pathology International

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Macrophages, which are derived from precursor cells in the bone marrow, differentiate specifically under the influence of the local microenvironment. Resident macrophages in hematopoietic tissues can be distinguished from other stromal cells and monocytes by immunostaining with monoclonal antibody F4/80 and anti-Forssman glycosphingolipid antibody, respectively. Erythroid colony-forming units adhere to a resident macrophage and differentiate to erythroblasts in the presence of erythropoietin (EPO), resulting in the formation of an erythroblastic island. Resident macrophages play a supportive role in erythropoiesis, probably by preventing apoptosis of the erythroid precursors via adhesive interaction between very late activation antigen 4 and vascular cell adhesion molecule 1. Herein is proposed a model of erythropoiesis based on cooperative interaction between EPO and resident macrophages.

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Effects of monocyte‐macrophage colony‐stimulating factor (M‐CSF) on in vitro erythropoiesis of marrow progenitor cells from patients with renal anemia

Cited by 5 publications

References 9 publications

Association of plasma macrophage colony-stimulating factor with cardiovascular morbidity and all-cause mortality in chronic hemodialysis patients

Association of plasma macrophage colony-stimulating factor with cardiovascular morbidity and all-cause mortality in chronic hemodialysis patients

In vitro expansion of human cord blood CD36+ erythroid progenitors: Temporal changes in gene and protein expression

Role of the macrophage in erythropoiesis

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