Effects of Monotherapy of Temocapril or Candesartan with Dose Increments or Combination Therapy with Both Drugs on the Suppression of Diabetic Nephropathy

Microalbuminuria Reduction with Telmisartan in Normotensive and Hypertensive Japanese Patients with Type 2 Diabetes: A Post-Hoc Analysis of the Incipient to Overt: Angiotensin II Blocker, Telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) Study

“…Further studies by Rossing et al (26) demonstrated that the antiproteinuric effect of irbesartan at ultrahigh dosage (900 mg once daily) was superior to the usual recommended dose (300 mg) in hypertensive type 2 diabetic patients. Similar results were also reported by Ogawa et al (7) who showed that candesartan's effects on albuminuria were dose-dependent in Japanese hypertensive type 2 diabetic patients. However, in the present study, the dose-dependent effects of telmisartan at 40 and 80 mg on UACR were not observed in hypertensive patients.…”

“…3B). Thus, it is possible that during angiotensin blockade with telmisartan, there is an important relationship between blood pressure reduction and reduction in albuminuria in hypertensive type 2 diabetic patients, as suggested by other clinical studies (7,24,25).…”

“…In the present study, over 70% of hypertensive patients were treated with CCBs, whereas previous studies used a washout period of a few weeks to eliminate all antihypertensive medications, or their subjects were previously untreated moderate hypertensive patients (6,7,26). Other possibilities cannot be ruled out and need to be examined further.…”

“…31 (2008) , Masakazu HANEDA 2) , Tetsuya BABAZONO 3) , Tatsumi MORIYA 4) , Sadayoshi ITO 5) , Yasuhiko IWAMOTO 6) , Ryuzo KAWAMORI 7) , Masahiro TAKEUCHI 8) , and Shigehiro KATAYAMA 9) , for the INNOVATION Study Group…”

Combination Therapy with Renin-Angiotensin System Inhibitors and the Calcium Channel Blocker Azelnidipine Decreases Plasma Inflammatory Markers and Urinary Oxidative Stress Markers in Patients with Diabetic Nephropathy

“…Reducing BP is known to decrease ACR (39). In the present study, greater reductions of BP were associated with greater decreases in ACR in both the AZ and NF group.…”