Effects of Montreal municipal sewage effluents on immune responses of juvenile female rainbow trout (Oncorhynchus mykiss)

Salo, Harri M.; Hebert, Nancy; Dautremepuits, Claire; Čejka, Patrick; Cyr, Daniel G.; Fournier, Michel

doi:10.1016/j.aquatox.2007.06.014

Cited by 44 publications

(23 citation statements)

References 24 publications

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“…4b). Studies conducted under laboratory conditions in which rainbow trout were exposed to Montreal wastewater effluents confirmed the immunotoxic potential of these effluents (Salo et al 2007;Escarné et al 2008;Hébert et al 2008). Tests of various fractions of effluents clearly showed that the soluble fraction from which bacteria and suspended materials were systematically removed retained immunotoxic effects, indicating that the immunotoxicity of the effluent was not due exclusively to its bacterial content (Hébert et al 2008).…”

Section: Effects On Fish Immune Functionmentioning

confidence: 82%

“…Phagocytic activities of pronephric macrophages and of granulocytes were suppressed following a 1 week exposure, with the greatest suppressive effects being observed at the highest exposure concentration. Surprisingly, phagocytic activity returned to control levels or was enhanced after 4 weeks, but was reduced again at 13 weeks (Salo et al 2007;Hébert et al 2008). The cytotoxic activity of non-specific cytotoxic cells from the head kidney was enhanced after a 1-week exposure, especially at the lowest exposure concentration, but rebounded to control levels after 4 weeks (Salo et al 2007).…”

Section: Effects On Fish Immune Functionmentioning

confidence: 89%

“…The cytotoxic activity of non-specific cytotoxic cells from the head kidney was enhanced after a 1-week exposure, especially at the lowest exposure concentration, but rebounded to control levels after 4 weeks (Salo et al 2007). Lymphocyte proliferation in response to the mitogens lipopolysaccharide (LPS) and concanavilin A (ConA) activation was not affected following exposure to sewage effluents, but non-activated, spontaneous proliferation of lymphocytes was suppressed in a dose-dependent manner after 4 and 13 weeks of exposure (Salo et al 2007;Hébert et al 2008). Plasma lysozyme activity was elevated at the lowest exposure concentration after 4 weeks.…”

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

“…Plasma lysozyme activity was elevated at the lowest exposure concentration after 4 weeks. The proportion of circulating granulocytes increased following exposure for 4 weeks to the low effluent concentration, but no change was observed in either the blood leukocyte/erythrocyte ratio or the proportion of lymphocytes and thrombocytes (Salo et al 2007). Thus, various immune functions were differentially affected, depending on both the concentration and duration of exposure.…”

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

“…A series of experiments characterized the chronic toxicity of the effluents in juvenile female rainbow trout exposed under laboratory conditions to Montreal wastewater effluent for 1, 4, and 13 weeks to varying concentrations of sewage effluent (Salo et al 2007;Hébert et al 2008). Phagocytic activities of pronephric macrophages and of granulocytes were suppressed following a 1 week exposure, with the greatest suppressive effects being observed at the highest exposure concentration.…”

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

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Effects of a major municipal effluent on the St. Lawrence River: A case study

Marcogliese

Blaise

Cyr

et al. 2014

AMBIO

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The St. Lawrence River (SLR) is the second largest waterway in North America. The discharge of the City of Montreal wastewater treatment plant (WWTP) represents the largest volume of treated wastewaters being released into the river. It also ranks as the largest sewage treatment plant of its kind in North America. Over the last decade, intensive multidisciplinary research has focused on assessing the impacts of Montreal wastewater effluents on the SLR. We describe the major findings of these investigations, including the determination of the fate of contaminants, bioaccumulation in fish and invertebrates, ecotoxicological measurements of aquatic animal health, evaluation of endocrine disruption, parasitism in fish, and combined effects of multiple stressors on the SLR. Impacts of the effluents from the WWTP on aquatic organisms from the SLR are both toxicological and ecological, demonstrating the need for an integrated view of the impacts of municipal effluents on aquatic ecosystems.

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Section: Effects On Fish Immune Functionmentioning

confidence: 82%

Section: Effects On Fish Immune Functionmentioning

confidence: 89%

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

Section: Effects On Fish Immune Functionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of a major municipal effluent on the St. Lawrence River: A case study

Marcogliese

Blaise

Cyr

et al. 2014

AMBIO

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Detrimental Effects of Metronidazole on Selected Innate Immunological Indicators in Common Carp (Cyprinus carpio L.)

Han

Zhang

Yang

et al. 2013

Bull Environ Contam Toxicol

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The widely used antibiotic metronidazole (MTZ) was investigated for its toxic effects on the innate immunity in common carp (Cyprinus carpio L.). The fish were exposed to MTZ at nominal concentrations of 0.1, 0.5, and 2.5 mg L(-1) in water for 30 days, followed by a 5-days of cleanout period, after which certain innate immunity parameters were measured. The results showed that under the tested concentrations, MTZ-exposed fish exhibited decline in several humoral and cellular parameters, including complement activity, lysozyme activity, bactericidal activity, total serum protein levels, total WBC count, and the respiratory burst activity of kidney leukocytes. Except for total serum proteins, all of these parameters showed a significant difference in the 2.5 mg L(-1) MTZ group compared to control group (p < 0.05). The results clearly support the contention that MTZ suppresses the innate immunity of common carp.

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Responses of primary cultured haemocytes derived from the marine gastropod Haliotis tuberculata to an industrial effluent exposure

et al. 2016

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This study assessed the responses of primary cultured haemocytes from the marine gastropod Haliotis tuberculata exposed to the increasing concentrations of industrial effluent (0, 0.5, 1, 10, 15 and 20%) discharged into the Tunisian coastal area. Analyses showed the presence of metals such as cadmium (Cd), chromium (Cr), copper (Cu), manganese (Mn), zinc (Zn), nickel (Ni) and lead (Pb) in the effluent. The effects of this mixture of pollutants on abalone haemocyte parameters were reflected by a significant decrease of cell viability, phagocytotic activity and reactive oxygen species (ROS) production as well as morphological and lysosomal membrane alterations. Thus, these results indicated that our primary culture system represents a suitable in vitro model for monitoring of anthropogenic contaminants in aquatic environments.

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Effects of Montreal municipal sewage effluents on immune responses of juvenile female rainbow trout (Oncorhynchus mykiss)

Cited by 44 publications

References 24 publications

Effects of a major municipal effluent on the St. Lawrence River: A case study

Effects of a major municipal effluent on the St. Lawrence River: A case study

Detrimental Effects of Metronidazole on Selected Innate Immunological Indicators in Common Carp (Cyprinus carpio L.)

Responses of primary cultured haemocytes derived from the marine gastropod Haliotis tuberculata to an industrial effluent exposure

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