Effects of mothers' prenatal psychiatric status and postnatal caregiving on infant biobehavioral regulation: Can prenatal programming be modified?

Kaplan, Lauren; Evans, Lynn; Monk, Catherine

doi:10.1016/j.earlhumdev.2007.06.004

Cited by 175 publications

(141 citation statements)

References 47 publications

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“…First, our sample size was relatively small to represent the general population, even though it was larger than those in several previous studies [10][11][12]. However, despite the small sample size, the goodness of fit in all of the adjusted models of linear regression analyses indicated statistical significance (p \ 0.05), thereby endorsing the validity of the study results.…”

Section: Study Strengths and Limitationsmentioning

confidence: 65%

“…We assessed maternal depression between the second and third trimesters since this is the period of fetal development, and previous studies also assessed maternal psychological distress during this period [6,11,12]. The EPDS is a widely used self-rating questionnaire [18] and has been used during the antenatal period even though originally developed as a screening tool for maternal depression following childbirth [6].…”

Section: Exposure Measurementioning

confidence: 99%

“…Although some studies have insisted that antenatal depression is related to lower infant development scores that indicate a developmental delay [6,10], others have related antenatal depression to higher performance in infant development tests [11] or have shown no correlation with infant development [12]. The ALSPAC study [6] and the study by DiPietro et al [11] demonstrated contradictory effects of antenatal depression, despite the fact that both studies were conducted using prospective birth cohorts and applied globally standardised measures, including the Edinburgh Postnatal Depression Scale (EPDS) or the Center for Epidemiologic Studies Depression Scale for assessing maternal depression, and the Denver Developmental Screening Test (DDST) or the Bayley Scales of Infant Development II (BSID-II) for assessing infant development.…”

Section: Introductionmentioning

confidence: 99%

“…In these studies, researchers controlled for diverse maternal and infant factors, including antenatal and postnatal maternal psychological distress, maternal smoking during pregnancy, maternal age, maternal educational level, infant birth weight and gender and infant age at the time of developmental assessment [6,[10][11][12]. However, they did not consider differences in the rearing attitude of the parents or in the home environment.…”

Section: Introductionmentioning

confidence: 99%

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Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study

Otake

Nakajima

Uno

et al. 2013

Environ Health Prev Med

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Objective To examine the association between antenatal depression and infant development after controlling for confounding factors. Methods A hospital-based prospective cohort study (Hokkaido Study on Environment and Children's Health) was conducted between July 2002 and October 2005 in Sapporo, Japan. Of 309 mothers who delivered at Sapporo Toho Hospital during the study period and who agreed with the clinical assessment of depression, 154 mother-infant pairs were eligible for analysis. Antenatal depression was assessed between the second and third trimesters using the Edinburgh Postnatal Depression Scale (EPDS), and infant development was assessed at 6 months by the Bayley Scales of Infant Development II (BSID-II). Data on potential confounders, including socioeconomic status, birth complications, postnatal depression and child care environment, were obtained from medical records and selfadministered questionnaires. Univariable and multivariable analyses were conducted in which the EPDS score was entered as an independent variable and the BSID-II scores as a dependent variable, adjusting for confounders. Results Although the antenatal EPDS score tended to be related to the BSID-II score in the univariable analysis, this correlation was lost in the multivariable analysis. However, based on a series of linear regression analyses, antenatal depression was found to be significantly related to shorter gestational age (b = -0.25, 95 % confidence interval (CI) [-1.20, -0.17]), and shorter gestational age was significantly related to a lower BSID-II (mental development) score (b = 0.23, 95 % CI [0.00, 0.00]). Conclusions Gestational age is an important confounder in the association between maternal antenatal depression and infant development. A delay in infant development may be related to a shorter gestational period caused by maternal depression during pregnancy.

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Section: Study Strengths and Limitationsmentioning

confidence: 65%

Section: Exposure Measurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study

Otake

Nakajima

Uno

et al. 2013

Environ Health Prev Med

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“…Um possível foco terapêutico na intervenção com mãe e fi lhos poderia ser a sensibilização parental a sinais emitidos pela criança assim como um aumento no contato entre cuidador e criança (Kaplan, Evans, & Monk, 2008). O estudo mostrou altos níveis de variabilidade da taxa de batimentos cardíacos em situações de repouso, baixos níveis de reatividade cardíaca e de cortisol em situações de estresse moderado em crianças cujas cuidadoras foram previamente consideradas como "sensíveis", ou seja, com escores abaixo da média da classifi cação de depressão ou transtornos de ansiedade.…”

Section: Implicações Para Possíveis Intervenções Em Neurodesenvolvimeunclassified

Epigenética, Cuidados Maternais e Vulnerabilidade ao Estresse: Conceitos Básicos e Aplicabilidade

Noro¹,

Gon²

2015

Psicol. Reflex. Crit.

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ResumoCuidados maternais são experiências do início da vida que têm sido consistentemente relacionados com alterações na expressão gênica por meio de mecanismos epigenéticos como a metilação do DNA ou a modifi cação de suas histonas. O objetivo deste trabalho é apresentar uma investigação teórica sobre cuidados maternais enquanto evento ambiental que pode produzir alterações epigené-ticas atuantes na composição da vulnerabilidade ao estresse. A investigação teve por base estudos empíricos e de revisão de literatura com animais não humanos sobre Epigenética, estresse e cuidados maternais. Apresenta também alguns estudos com humanos que mostram tais efeitos, destacando-se aqueles que infl uenciam ou são infl uenciados pelo comportamento operante. A partir da investigação realizada encontrou-se que cuidados maternais pós-parto são uma condição ambiental que produz efeitos no eixo hipotálamo-pituitária-adrenal (HPA), participando da composição da vulnerabilidade ao estresse. Seus possíveis efeitos fi siológicos no condicionamento operante sinalizam alternativas para intervenções baseadas na plasticidade da formação do epigenoma. Este conhecimento, além de promover a aproximação entre a Epigenética e a Análise do Comportamento em nível básico por meio de estudos com animais não humanos, poderá contribuir em nível aplicado para um melhor entendimento do neurodesenvolvimento infantil e adequado planejamento de intervenções efetivas com mães e fi lhos. Palavras-chave: Cuidados maternais, Epigenética, vulnerabilidade ao estresse, neurodesenvolvimento, Análise do Comportamento. AbstractMaternal care is an early life experience that has been consistently related to alterations in the genetic expression through epigenetic mechanisms such as DNA methylation or DNA histone modifi cation. The present study aims to present a theoretical investigation about maternal care as an environmental event that may produce epigenetic alterations related to the biological bases of stress vulnerability. The research was based on empirical studies as well as literature review on non-human animals concerning epigenetics, stress and maternal care. It also presents some studies on humans that show such effects, particularly the ones that infl uence or are infl uenced by the operant behavior. Post-natal maternal care is found to cause effects on the hypothalamic-pituitary-adrenal (HPA) axis activity participating in the building of stress vulnerability. Its possible physiological effects on the operant conditioning point out to alternatives to intervention based on the plasticity of the epigenome formation. This knowledge enhances the proximity between Epigenetics and Behavior Analysis at a basic level through studies with non-human animals and at an applied level through a better understanding of child neurodevelopment and proper planning of effective intervention with mothers and children. Keywords: Maternal care, Epigenetics, stress vulnerability, neurodevelopment, Behavior Analysis. * Endereço para correspondência: R. Prof. Samuel Moura, 367...

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Maternal Intimate Partner Violence and Increased Asthma Incidence in Children

Suglia¹,

Enlow²,

Kullowatz³

et al. 2009

Arch Pediatr Adolesc Med

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Effects of mothers' prenatal psychiatric status and postnatal caregiving on infant biobehavioral regulation: Can prenatal programming be modified?

Abstract: Background-Animal research suggests that antenatal stress exposure and postnatal rearing style act in concert to shape offspring biobehavioral outcomes. However, the combination of these maternally-mediated influences has not been studied in human infants.

Cited by 175 publications

References 47 publications

Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study

Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study

Epigenética, Cuidados Maternais e Vulnerabilidade ao Estresse: Conceitos Básicos e Aplicabilidade

Maternal Intimate Partner Violence and Increased Asthma Incidence in Children

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