Effects of motherwort alkaloids on rat ear acne

Miao, Mingsan; Li, Yan; Wang, Tan; Wang, Ting; Bai, Ming; Jinxin, Miao; Gong, Bao

doi:10.3329/bjp.v11is1.25633

Cited by 4 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase in ear thickness confirmed the induction of inflammatory acne in rats. Similar results of induction were obtained by different investigations (Mingsan et al, 2016;Li et al, 2017;Han et al, 2018;Kumar et al, 2019).…”

Section: Discussionsupporting

confidence: 89%

Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne

Affo,

Bignoate,

Kossi

et al. 2024

J. Med. Plants Res.

View full text Add to dashboard Cite

The hydroethanolic extract of Aloe buettneri was assessed for its anti-acne activity in a Cutibacterium acnes-induced acne model in rats as part of this study. Conventional therapies for acne often entail serious side effects. Total phenols, quantified using the Folin-Ciocalteu method, were found to be at a concentration of 16 ± 0.3 mg GAE/g, while total flavonoids, determined using the aluminum chloride method, were measured at 2.83 ± 0.5 mg QE/g. High-performance liquid chromatography (HPLC) techniques identified four polysaccharidic flavonoids in the extract: protocatechuic acid, caffeic acid, homo-orientin, and ferulic acid. In the acne-induced rat model, the disease group exhibited increased ear thickness, rectal temperature, and MDA level, along with a decrease in glutathione level (###p < 0.001). However, significant improvement in these parameters was observed after 12 days of topical treatment (***p < 0.001). The identified molecules in the A. buettneri extract, including protocatechuic acid, caffeic acid, homo-orientin, and ferulic acid, may contribute to the observed anti-acne properties.

show abstract

Section: Discussionsupporting

confidence: 89%

Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne

Affo,

Bignoate,

Kossi

et al. 2024

J. Med. Plants Res.

View full text Add to dashboard Cite

show abstract

The Effect of Leonuri Herba alkaloids on Senile BPH (male and female hormone induced) model rats

Miao

Wang

Liu

et al. 2017

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

To investigate the pharmacological effects of Leonuri Herba alkaloids (LHA) on prostate hyperplasia in older rats and the effect mechanism. Remove bilateral testes from BPH model rats, and conduct subcutaneous injection of testosterone and estradiol. At the same time, feed corresponding drugs to the rats by gastric perfusion for 30d. In the first 27d, conduct bladder fistula surgery. Three days after feeding, carry out the detection of the urine flow dynamics. Eyeball blood taking, determination of serum E2 levels, and quickly remove the prostate, thymus gland, spleen, kidney, lung, and bladder. 1/3 prostate homogenate, determine the level of PACP, T, DHT. 1/3 prostate was determined by mRNA expression in bFGF. The remaining 1/3 prostate was observed by light microscopy. LHA could significantly decrease the animal prostate index, level of DHT, T, PACP, and elevate levels of E2 in the serum. It could also significantly reduce the maximum voiding pressure, intercontraction interval, and bladder resting pressure. LHA has good therapeutic effect on prostatic hyperplasia model rats induced by male and female hormone.

show abstract

Effect of Total Alkali in Leonuri Herba on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology

Peng

Wang

et al. 2017

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

To investigate the effect of Total Alkali in Leonuri Herba (TALH) on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology. The rats were divided into the TALH group at high, medium and low doses (200 mg kg, 100 mg·kg, 50 mg·kg), the tanshinone group (360 mg·kg), model group and the blank group. All the rats were administrated once a day for 14 days. At the same time on the first day, the rats in the blank group were injected normal saline in the stomach and also had intradermal injection of sterile saline in the auricle. The rats in other groups (model group were lavaged with physiological saline) were injected intradermally auricle spare bacteria liquid. After the injection, the rat ear swelling rate was calculated for 5 consecutive days in terms of rat auricle thickness measurement. 1 h after the last administration, the eyeball blood was removed, centrifuged to separate serum, and measured to be at serum IL-6 level; The tissue sections of thymus and spleen were observed according to morphology criteria. Compared with the blank group, the level of IL-6 in serum of the rats in the model group was remarkably higher, and those in the thymus and spleen groups were remarkably lower, indicating the rat ear acne model is successful. Compared with the model group, the rats in the TALH group can remarkably make serum IL-6 level decrease, causing significant thymus cortical thickening and increased spleen sections, and remarkably increasing the lymphocytes of thymus and spleen. The effect of large dose in the TALH group is the best and increases with the increase of the dose and curative effect. The TALH treatment of acne may be related to the reduction of serum IL-6 levels and the resistance of the atrophy of the thymus and spleen on the rat ear acne model.

show abstract

Effects of motherwort alkaloids on rat ear acne

Cited by 4 publications

References 2 publications

Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne

Comprehensive evaluation of antiacne properties: HPLC analysis of crude extract from Aloe buettneri leaves against Cutibacterium acnes-induced acne

The Effect of Leonuri Herba alkaloids on Senile BPH (male and female hormone induced) model rats

Effect of Total Alkali in Leonuri Herba on rat ear acne model of serum IL-6 level, Thymus and Spleen Tissue Morphology

Contact Info

Product

Resources

About