Effects of motor fatigue on human brain activity, an fMRI study

Duinen, Hiske van; Renken, Remco; Maurits, Natasha M.; Zijdewind, Inge

doi:10.1016/j.neuroimage.2007.02.008

Cited by 119 publications

(118 citation statements)

References 46 publications

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“…The decrease in cerebellum activity confirms previous data obtained in fatiguing submaximal contractions [van Duinen et al, 2007b;however, cf. Liu et al, 2003].…”

Section: Brain Areas and Roi Analysissupporting

confidence: 92%

“…The comparison between the activation during the last (T3) and first (T1) third of the sustained high-force contraction showed increased activation in clusters in the precentral gyrus, SMA, CMA, and the parietal operculum. These areas are comparable with areas that showed increased activation during a submaximal fatiguing task in the FDI [van Duinen et al, 2007b]. We analyzed the activity in these areas in more detail with a region of interest analysis (see ROI analysis).…”

Section: Brain Areas and Roi Analysismentioning

confidence: 90%

“…Several studies have investigated changes in brain activation during fatigue induced by a sustained or intermittent submaximal contraction [Benwell et al, 2007;Dettmers et al, 1996;Liu et al, 2003;van Duinen et al, 2007b]. The results of these studies were contradictory; one study showed no change in cortical activity [Dettmers et al, 1996] while the other three experiments showed an increase in activity of most motor areas [primary motor cortex, premotor areas: Benwell et al, 2007;Liu et al, 2003;van Duinen et al, 2007b]. Unfortunately, it is uncertain whether these changes were accompanied by central fatigue.…”

Section: Introductionmentioning

confidence: 99%

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Voluntary activation and cortical activity during a sustained maximal contraction: An fMRI study

Post

Steens

Renken

et al. 2008

Human Brain Mapping

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Motor fatigue is an exercise-induced reduction in the force-generating capacity. The underlying mechanisms can be separated into factors residing in the periphery or in the central nervous system. We designed an experiment in which we investigated central processes underlying motor fatigue by means of magnetic resonance imaging in combination with the twitch interpolation technique. Subjects performed a sustained maximal abduction (2 min) with the right index finger. Brain activation was recorded with an MR scanner, together with index finger abduction force, EMG of several hand muscles and interpolated twitches. Mean activity per volume was calculated for the primary motor cortex and the secondary motor areas (supplementary motor, premotor, and cingulate areas) as well as mean force and mean rectified EMG amplitude. Results showed a progressive decline in maximal index finger abduction force and EMG of the target muscles combined with an increase in brain activity in the contralateral primary motor cortex and secondary motor areas. Analysis of the twitches superimposed on the sustained contraction revealed that during the contraction the voluntary drive decreased significantly. In conclusion, our data showed that despite an increase in brain activity the voluntary activation decreased. This suggests that, although the CNS increased its input to the relevant motor areas, this increase was insufficient to overcome fatigue-related changes in the voluntary drive.

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“…The decrease in cerebellum activity confirms previous data obtained in fatiguing submaximal contractions [van Duinen et al, 2007b;however, cf. Liu et al, 2003].…”

Section: Brain Areas and Roi Analysissupporting

confidence: 92%

Section: Brain Areas and Roi Analysismentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Voluntary activation and cortical activity during a sustained maximal contraction: An fMRI study

Post

Steens

Renken

et al. 2008

Human Brain Mapping

Self Cite

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“…Many neuroimaging studies test for linear relationships between signals that reflect activity at the neuronal level and experimental factors (e.g., forces) [Ashe, 1997; Dettmers et al, 1996; Ehrsson et al, 2001; Halder et al, 2007; Kuhtz‐Buschbeck et al, 2001, 2008; van Duinen et al, 2007], while the nature and meaning of non‐linear relationships—of the sort characterized by psychometric functions in psychophysics—have received less attention. Several reasons may explain this, including difficulties in interpretation and also, importantly, detecting them.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Alahmadi

Pardini

Samson

et al. 2017

Human Brain Mapping

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The relationship between the BOLD response and an applied force was quantified in the cerebellum using a power grip task. To investigate whether the cerebellum responds in an on/off way to motor demands or contributes to motor responses in a parametric fashion, similarly to the cortex, five grip force levels were investigated under visual feedback. Functional MRI data were acquired in 13 healthy volunteers and their responses were analyzed using a cerebellum‐optimized pipeline. This allowed us to evaluate, within the cerebellum, voxelwise linear and non‐linear associations between cerebellar activations and forces. We showed extensive non‐linear activations (with a parametric design), covering the anterior and posterior lobes of the cerebellum with a BOLD‐force relationship that is region‐dependent. Linear responses were mainly located in the anterior lobe, similarly to the cortex, where linear responses are localized in M1. Complex responses were localized in the posterior lobe, reflecting its key role in attention and executive processing, required during visually guided movement. Given the highly organized responses in the cerebellar cortex, a key question is whether deep cerebellar nuclei show similar parametric effects. We found positive correlations with force in the ipsilateral dentate nucleus and negative correlations on the contralateral side, suggesting a somatotopic organization of the dentate nucleus in line with cerebellar and cortical areas. Our results confirm that there is cerebellar organization involving all grey matter structures that reflect functional segregation in the cortex, where cerebellar lobules and dentate nuclei contribute to complex motor tasks with different BOLD response profiles in relation to the forces. Hum Brain Mapp 38:2566–2579, 2017. © 2017 Wiley Periodicals, Inc.

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“…In early neurological studies, motion signals were rarely obtained during fMRI experiments, due to the restriction of the strong magnetic field environment. Only a few studies on brain function during movement, which were based on simple tasks such as changing finger and wrist speed or involved imaginary finger sequencing, have been conducted (Cramer et al, 2002;Debraere, Wenderoth, Sunaert, Van Hecke, & Swinnen, 2004;Van Duinen, Remco, Natasha, & Inge, 2007). Since motion data were not obtained in these studies, an accurate analysis of the relationship between human movement and brain function has not been accomplished so far.…”

Section: Introductionmentioning

confidence: 99%

A simple 5-DoF MR-compatible motion signal measurement system

et al. 2011

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The purpose of this study was to develop a simple motion measurement system with magnetic resonance (MR) compatibility and safety. The motion measurement system proposed here can measure 5-DoF motion signals without deteriorating the MR images, and it has no effect on the intense and homogeneous main magnetic field, the temporalgradient magnetic field (which varies rapidly with time), the transceiver radio frequency (RF) coil, and the RF pulse during MR data acquisition. A three-axis accelerometer and a twoaxis gyroscope were used to measure 5-DoF motion signals, and Velcro was used to attach a sensor module to a finger or wrist. To minimize the interference between the MR imaging system and the motion measurement system, nonmagnetic materials were used for all electric circuit components in an MR shield room. To remove the effect of RF pulse, an amplifier, modulation circuit, and power supply were located in a shielded case, which was made of copper and aluminum. The motion signal was modulated to an optic signal using pulse width modulation, and the modulated optic signal was transmitted outside the MR shield room using a high-intensity light-emitting diode and an optic cable. The motion signal was recorded on a PC by demodulating the transmitted optic signal into an electric signal. Various kinematic variables, such as angle, acceleration, velocity, and jerk, can be measured or calculated by using the motion measurement system developed here. This system also enables motion tracking by extracting the position information from the motion signals. It was verified that MR images and motion signals could reliably be measured simultaneously.

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Effects of motor fatigue on human brain activity, an fMRI study

Cited by 119 publications

References 46 publications

Voluntary activation and cortical activity during a sustained maximal contraction: An fMRI study

Voluntary activation and cortical activity during a sustained maximal contraction: An fMRI study

Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

A simple 5-DoF MR-compatible motion signal measurement system

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