2004
DOI: 10.1159/000077526
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Effects of mRNA Untranslated Regions on Translational Efficiency of NMDA Receptor Subunits

Abstract: Because NMDA receptors play critical roles in both neuronal survival and plasticity, their expression levels need to be carefully controlled. The number of functional NMDA receptors is temporally and spatially regulated at a hierarchy of levels, from gene transcription to protein trafficking. In this review we will focus on mechanisms for controlling functional expression of NMDA receptors that involve altering the efficacy of mRNA translation. One advantage of this level of control is that new receptors can b… Show more

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Cited by 14 publications
(11 citation statements)
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References 140 publications
(133 reference statements)
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“…The translation of mRNA to protein is regulated by mechanisms that control 5Ј capping, 3Ј polyadenylation, splicing, RNA editing, mRNA transport, stability, and initiation and elongation ( VanDongen and VanDongen, 2004;Coyle, 2009). The 5Ј-UTR of most glutamate receptor mRNAs is unusually long.…”
Section: Translational Control Of Glutamate Receptorsmentioning
confidence: 99%
See 1 more Smart Citation
“…The translation of mRNA to protein is regulated by mechanisms that control 5Ј capping, 3Ј polyadenylation, splicing, RNA editing, mRNA transport, stability, and initiation and elongation ( VanDongen and VanDongen, 2004;Coyle, 2009). The 5Ј-UTR of most glutamate receptor mRNAs is unusually long.…”
Section: Translational Control Of Glutamate Receptorsmentioning
confidence: 99%
“…The 5Ј-UTR of most glutamate receptor mRNAs is unusually long. These long 5Ј-UTRs often exhibit stretches of high GC content and sometimes contain multiple out-of-frame AUG codons that could act as decoys for scanning ribosomes, reducing or preventing translation initiation at the true glutamate receptor AUG VanDongen and VanDongen, 2004). Translational suppression has been inferred for GluN1 mRNA natively expressed in PC12 cells because no GluN1 protein can be detected despite a moderately high mRNA level (Sucher et al, 1993).…”
Section: Translational Control Of Glutamate Receptorsmentioning
confidence: 99%
“…Although the rate of transcription is a relevant step in the regulation of several receptor subunit mRNAs expression [39,40], there are multiple levels of posttranscriptional regulation [38,41]. The changes in the mRNAs levels reported in this paper are established in only 1 h of hypoxia.…”
Section: Discussionmentioning
confidence: 65%
“…It is known that NMDA receptors subunits play critical developmental roles and their expression levels are carefully controlled [38]. Although the rate of transcription is a relevant step in the regulation of several receptor subunit mRNAs expression [39,40], there are multiple levels of posttranscriptional regulation [38,41].…”
Section: Discussionmentioning
confidence: 99%
“…Potential molecular mechanisms underlying this type of control of NMDA receptor expression and evidence of translational regulation of NR2 subunits are reviewed in the paper by VanDongen and VanDongen [24] in this volume. Intracellular trafficking of NMDA receptors is reviewed by Perez-Otaño and Ehlers [25].…”
Section: Introductionmentioning
confidence: 99%