Effects of Mulberry on The Central Nervous System: A Literature Review

Tam, Dao Ngoc Hien; Nam, Nguyen Hai; Elhady, Mohamed Tamer; Tran, Linh; Hassan, Osama; Sadik, Mohamed; Tien, Phan Thi My; Elshafei, Ghada Amr; Huy, Nguyen Tien

doi:10.2174/1570159x18666200507081531

Cited by 20 publications

(10 citation statements)

References 70 publications

(175 reference statements)

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“…Additionally, VEGF levels were rapidly upregulated after traumatic injury of the central nervous system 38 . Moreover, some research revealed that amber, cinnabaris, chrysanthemum, mulberry leaf might protect neuronal cells in the central nervous system 39–42 . Therefore, we speculated that HPASD equally with a protective effect on the nervous system.…”

Section: Discussionmentioning

confidence: 94%

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Hu'po Anshen decoction promotes fracture healing in mice with traumatic brain injury through BMP2‐COX2‐ATF4 signaling pathway

Ding

Yao

et al. 2023

The FASEB Journal

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Hu'po Anshen decoction (HPASD), a traditional Chinese medicine used to treat concussion and fracture, could regulate the expression of bone morphogenetic protein 2 (BMP2). However, whether HPASD affects the fracture healing of traumatic brain injury (TBI) combined with a fracture through BMP2 and its downstream signals remains obscure. The chondrocyte-specific BMP2 conditional knockout mice and chondrocyte-specific cyclooxygenase-2 (COX2) overexpression mice were generated. BMP2 conditional knockout mice were treated with fracture surgery, fracture combined with TBI, or fracture combined with TBI followed by different doses of HPASD (2.4, 4.8, and 9.6 g/kg), respectively. TBI was induced by Feeney's weight-drop technique. The fracture callus formation and fracture sites were determined by X-ray, micro-CT, and histological analyses. The expressions of chondrocyte-, osteoblast-, and

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Section: Discussionmentioning

confidence: 94%

“…38 Moreover, some research revealed that amber, cinnabaris, chrysanthemum, mulberry leaf might protect neuronal cells in the central nervous system. [39][40][41][42] Therefore, we speculated that HPASD equally with a protective effect on the nervous system. However, there is no specific mechanism for fracture repair.…”

Section: Discussionmentioning

confidence: 99%

Hu'po Anshen decoction promotes fracture healing in mice with traumatic brain injury through BMP2‐COX2‐ATF4 signaling pathway

Ding

Yao

et al. 2023

The FASEB Journal

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“…However, Morus alba called mulberry has been evaluated as a safe herb showing no side effects [16,17]. The fruits, leaves, branches, and roots of mulberry possess a range of biological treatment effects on numerous human diseases [18,19], including diabetes, neurological disorders, cardiovascular diseases, and cancers [20][21][22][23][24]. However, there has not been sufficient research proving that mulberry can function as a therapeutic agent in oral diseases and its related oral risk factors.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms

Kim

Kang

2022

IJERPH

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Mulberry leaves extract (Morus alba extracts; MAE) is known to have therapeutic potentials for numerous human diseases, including diabetes, neurological disorders, cardiovascular diseases, and cancers. However, there has not been sufficient research proving therapeutic effects on oral disease and its related oral risk factors. Thus, we investigated whether MAE has any anti-inflammatory and anti-bacterial effects on risk factors causing oral infectious diseases. To examine the anti-inflammatory response and bacterial inhibition of MAE, we measured intracellular reactive oxygen species (ROS) generation, production of pro-inflammatory cytokines, and the bacterial growth rate. Our study showed that MAE has anti-inflammatory activities, which inhibit the ROS generation and suppressed the production of pro-inflammatory cytokines (TNF-α and IL-6) in human monocyte THP-1 cells by stimulating lipopolysaccharide (LPS) and/or F. nucleatum, which are the virulent factors in periodontal diseases. Furthermore, MAE inhibited the bacterial growth on oral microorganisms (F. nucleatum and S. mutans) infected THP-1 cells. These findings suggested that MAE could be a potential natural source for therapeutic drugs in oral infectious disease.

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“…At present, mulberry leaf tea has been developed in various forms as a functional food in the prevention and treatment of diabetes in China [19][20][21]. Modern studies have proved that mulberry leaves are rich in alkaloids, flavonoids, polysaccharides and other functional components, which can reduce blood sugar, blood pressure, blood lipids, antiaging, anti-oxidation and anti-nervous system diseases [22][23][24][25]. Recently, "total alkaloids from Ramulus Mori", the first new approved TCM for diabetes in the past 10 years in China, was put on the market.…”

Section: Introductionmentioning

confidence: 99%

Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism

Liu

Zhou

et al. 2022

Molecules

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Diabetes is a chronic metabolic disease, whereas α-glucosidases are key enzymes involved in the metabolism of starch and glycogen. There is a long history of the use of mulberry leaf (the leaf of Morus alba) as an antidiabetic herb in China, and we found that chalcomoracin, one of the specific Diels–Alder adducts in mulberry leaf, had prominent α-glucosidase inhibitory activity and has the potential to be a substitute for current hypoglycemic drugs such as acarbose, which have severe gastrointestinal side effects. In this study, chalcomoracin was effectively isolated from mulberry leaves, and its α-glucosidase inhibition was studied via enzymatic kinetics, isothermal titration (ITC) and molecular docking. The results showed that chalcomoracin inhibited α-glucosidase through both competitive and non-competitive manners, and its inhibitory activity was stronger than that of 1-doxymycin (1-DNJ) but slightly weaker than that of acarbose. ITC analysis revealed that the combination of chalcomoracin and α-glucosidase was an entropy-driven spontaneous reaction, and the molecular docking results also verified this conclusion. During the binding process, chalcomoracin went into the “pocket” of α-glucosidase via hydrophobic interactions, and it is linked with residues Val544, Asp95, Ala93, Gly119, Arg275 and Pro287 by hydrogen bonds. This study provided a potential compound for the prevention and treatment of diabetes and a theoretical basis for the discovery of novel candidates for α-glycosidase inhibitors.

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Effects of Mulberry on The Central Nervous System: A Literature Review

Cited by 20 publications

References 70 publications

Hu'po Anshen decoction promotes fracture healing in mice with traumatic brain injury through BMP2‐COX2‐ATF4 signaling pathway

Hu'po Anshen decoction promotes fracture healing in mice with traumatic brain injury through BMP2‐COX2‐ATF4 signaling pathway

Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms

Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism

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