Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis

Gómez-Soria, Isabel; Marín-Puyalto, Jorge; Peralta-Marrupe, Patricia; Latorre, Eva; Calatayud, Estela

doi:10.1016/j.archger.2022.104751

Cited by 17 publications

(7 citation statements)

References 46 publications

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“…These domains, including orientation, attention, calculation, and recall, are valuable predictors of cognitive function in individuals with suspected mild cognitive impairment (MCI). [ 33 ] Given that the participants in this study had potentially reversible early cognitive impairment, the improvements in orientation and recall suggest that the K‐MIND diet could prevent cognitive impairment. Although the K‐MMSE‐2 is a practical tool for assessing the severity of cognitive impairment, it has limitations as a diagnostic procedure.…”

Section: Resultsmentioning

confidence: 99%

Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

Kang,

Kim,

Kim

et al. 2023

Molecular Nutrition Food Res

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ScopeMild cognitive impairment is associated with a high prevalence of dementia. The study examines the benefits of a modified Korean MIND (K‐MIND) diet and explores biomarkers using multi‐omics analysis.Methods and resultsThe K‐MIND diet, tailored to the elderly Korean population, includes perilla oil, milk, or fermented milk, and avoids alcohol consumption. As a result, the K‐MIND diet significantly improves subjects “orientation to place” in the Korean version of the Mini‐Mental State Examination, 2nd edition test. According to multi‐omics analysis, the K‐MIND diet upregulates genes associated with mitochondrial respiration, including ubiquinone oxidoreductase, cytochrome C oxidase, and ATP synthase, and immune system processes, and downregulates genes related to nuclear factor kappa B activity and inflammatory responses. In addition, K‐MIND affects the metabolic pathways of glycine, serine, threonine, tryptophan, and sphingolipids, which are closely linked to cognitive function through synthesis of neurotransmitters and structures of brain cell membranes.ConclusionThe findings imply that the K‐MIND diet improves cognitive function by upregulating key genes involved in oxidative phosphorylation and downregulating pro‐inflammatory cytokines.

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Section: Resultsmentioning

confidence: 99%

Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

Kang,

Kim,

Kim

et al. 2023

Molecular Nutrition Food Res

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“…Thus, early and effective intervention is essential to delay or prevent further deterioration [13]. In other words, the progressive development of dementia and its adverse effects cannot be cured given the absence of effective pharmacological treatment [13,14] non-pharmacological interventions are needed.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, studies of PE intervention-that include aerobic exercise, resistance training, strength training, or postural balance-have shown improvements in cognitive abilities, like global cognition, logical memory, inhibitory control, attention, and executive functions, like Symbol Digit tests, Verbal Fluency, and Stroop [17,[19][20][21][22][23]-motor abilities, quality of life and reductions in psychological symptoms, like depression and anxiety in older adults with MCI [24]. In addition, a cognitive intervention is either cognitive stimulation (containing a group of activities with the view to increase cognitive and social functioning), cognitive rehabilitation (individual intervention designed to address cognitive and behavioral deficits), or cognitive training (which includes tasks that aim to provide a set of standardized tasks) [14,25].…”

Section: Introductionmentioning

confidence: 99%

Effects of Virtual Reality Physical and Cognitive Training Intervention On Cognitive Abilities of Elders with Mild Cognitive Impairment

Baldimtsi,

Mouzakidis,

Karathanasi

et al. 2023

Journal of Alzheimer's Disease Reports

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Background: Virtual reality (VR) technology has become increasingly used for assessment and intervention in the neuroscience field. Objective: We aimed to investigate the effects of a VR Training System, named VRADA (VR Exercise App for Dementia and Alzheimer’s Patients), on the cognitive functioning of older people with mild cognitive impairment (MCI). Methods: In this intervention study, 122 older adults with MCI were randomly assigned to five groups (the VRADA group (n = 28), a bike group (n = 11), a physical exercise group (n = 24), a mixed group (physical and cognitive exercise) (n = 31), and a non-contact control group (n = 28). The VRADA group underwent 32 physical and cognitive training sessions, performed 2 or 3 times weekly for 12 weeks in the VR environment. All participants had detailed neuropsychological assessments before and after intervention. Results: A series of linear regression models revealed that the VRADA group showed improvement or no deterioration in cognitive decline in global cognitive function (MMSE), verbal memory (Rey Auditory Verbal Learning Test and WAIS forward test), and executive functions, mental flexibility (Trail Making Test B). Conclusions: This interventionstudy indicates that the VRADA system improves the cognitive function of elders with MCI.

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“…Nonpharmacological multi‐component intervention consists of two or more nonpharmacological intervention methods. These interventions include but are not limited to physical activity, cognitive activity, social activity and activities of daily living (ADL) (Gómez‐Soria et al., 2022). Based on a previous study, nonpharmacological interventions should be preferred for depression symptoms in patients with mild‐to‐moderate dementia (Hughes et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of nonpharmacological multi‐component intervention on depressive symptoms in patients with mild cognitive impairment and dementia: A systematic review and meta‐analysis

Cai,

Bai,

Hou

et al. 2023

Int J Mental Health Nurs

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Patients with mild cognitive impairment (MCI) and dementia are more prone to depression than people without MCI or dementia. Some studies have found nonpharmacological multi‐component intervention to be more effective than single‐component intervention in improving the condition of patients with MCI and dementia; however, their effect on depressive symptoms is still inconsistent. Therefore, it is necessary to explore the effectiveness of nonpharmacological multi‐component intervention in improving depressive symptoms in patients with MCI and dementia. This review retrieved papers from PubMed, Embase, Cochrane Library, CINAHL, PsycINFO and CNKI. The retrieval time limit was set from 1 January 1990 to 25 November 2022. The PRISMA 2020 guideline was used to report the included studies. The result showed that nonpharmacological multi‐component intervention could improve depressive symptoms in patients with MCI and dementia. Among them, nonpharmacological multi‐component intervention with a duration of <6 months, physical and cognitive activities, or other activities had significant effects. However, each study differed in terms of specific measures, duration and frequency of intervention methods. Accordingly, more randomized controlled trials with larger samples are required to discover the best scheme for nonpharmacological multi‐component intervention.

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Effects of multi-component non-pharmacological interventions on cognition in participants with mild cognitive impairment: A systematic review and meta-analysis

Cited by 17 publications

References 46 publications

Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation

Effects of Virtual Reality Physical and Cognitive Training Intervention On Cognitive Abilities of Elders with Mild Cognitive Impairment

Effectiveness of nonpharmacological multi‐component intervention on depressive symptoms in patients with mild cognitive impairment and dementia: A systematic review and meta‐analysis

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