Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer's disease and its neurophysiological correlates: A double-blind randomized clinical trial

Andrade, Suellen Marinho; Machado, Daniel Gomes da Silva; Silva-Sauer, Leandro da; Regis, Cláudio Teixeira; Mendes, Cristina Kátya Torres Teixeira; Araújo, Juliana Sousa Soares de; Araújo, Kleyber Dantas Torres de; Costa, Larissa Pereira; Queiroz, Maria Eduarda Bezerra Sales; Leitão, Márcio Martins; Fernández‐Calvo, Bernardino

doi:10.1016/j.neucli.2022.02.003

Cited by 22 publications

(16 citation statements)

References 76 publications

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“…The suggested modulation of inflammatory processes by tDCS, either by direct brain stimulation [ 49 , 50 ] or top-down (vagal) processes, may be a parallel therapeutic mechanism [ 17 , 22 ]. As a further explanation of our study outcomes, rehabilitation programs are known to decrease sensation of fatigue accompanied by brain functional reorganization in the sensory-motor network [ [49] , [50] , [51] ] and tDCS enhances sensoriomotor activities and plasticity [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Non-invasive brain stimulation for fatigue in post-acute sequelae of SARS-CoV-2 (PASC)

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Non-invasive brain stimulation for fatigue in post-acute sequelae of SARS-CoV-2 (PASC)

et al. 2023

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“…All but two studies (Inagawa, 2021; Inagawa et al, 2019) used computerized CT programs. Seven studies (10%) reported that a therapist provided the CT (Andrade et al, 2022; Chapman, n.d.; Das et al, 2019; Manenti et al, 2018; Mattioli et al, 2016; Rodella et al, 2021; Zhang et al, 2019). In all other studies, either a research assistant or study technician ( k = 4; 6%) administered the training, or it was not mentioned by whom the training was administered ( k = 61; 85%, categorized as “computerized” for the analyses).…”

Section: Resultsmentioning

confidence: 99%

“…The total estimated standard deviation within and between studies was 0.63, indicating substantial heterogeneity. One effect size was identified as outlier (Andrade et al, 2022). Excluding this effect size estimate increased the effect size estimate ( g = 0.28, 95% CI [0.16, 0.40], p < .001) and reduced the total heterogeneity to 0.41.…”

Section: Resultsmentioning

confidence: 99%

The efficacy of combining cognitive training and noninvasive brain stimulation: A transdiagnostic systematic review and meta-analysis.

Poppe,

Ritter,

Bais

et al. 2024

Psychological Bulletin

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Over the past decade, an increasing number of studies investigated the innovative approach of supplementing cognitive training (CT) with noninvasive brain stimulation (NIBS) to increase the effects on outcomes. In this review, we aim to summarize the evidence for this treatment combination. We identified 72 published and unpublished studies (reporting 773 effect sizes), including 2,518 participants from healthy and clinical populations indexed in PubMed, MEDLINE, APA PsycInfo, ProQuest, Web of Science, and https://ClinicalTrials.gov (last search: August 9, 2022) that compared the effects of NIBS combined with CT on cognitive, symptoms, and everyday functioning to CT alone at postintervention and/or follow-up. We performed random-effects meta-analyses with robust variance estimation and assessed risk of bias with the Cochrane ROB tool. Only four studies had low risk of bias in all domains, and many studies lacked standard controls such as keeping the outcome assessor and trainer unaware of the treatment condition. Following sensitivity analyses, only learning/memory robustly improved significantly more when CT was combined with NIBS compared to CT only (g = 0.18, 95% CI [0.07, 0.29]) at postintervention, but not in the long term. The effect was small and limited by substantial heterogeneity. The other seven cognitive outcome domains, symptoms, and everyday functioning did not benefit from adding NIBS to CT. Given the methodological limitation of prior studies, more high-quality trials that focus on the potential of combining NIBS and CT to enhance benefits in everyday functioning in the short and long term are needed to evaluate whether combining NIBS and CT is relevant for clinical practice.

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“…Some studies have reported improvements in cognitive function, memory, and daily living activities following TES with AD [125,126]. Studies using tDCS have reported improved cognitive function and memory in individuals with AD [127][128][129][130]. The following is a summary in Table 3.…”

Section: Tes In Admentioning

confidence: 99%

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Yen

Lin

Chiang

2023

Life

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Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used neuroimaging techniques to review changes in brain activity. fMRI is a noninvasive technique that uses magnetic fields and radio waves to produce detailed brain images. An EEG is a noninvasive technique that records the brain’s electrical activity through electrodes placed on the scalp. This review overviews recent developments in noninvasive functional neuroimaging methods, including fMRI and EEG. Recent advances in fMRI technology, its application to studying brain function, and the impact of neuroimaging techniques on neuroscience research are discussed. Advances in EEG technology and its applications to analyzing brain function and neural oscillations are also highlighted. In addition, advanced courses in neuroimaging, such as diffusion tensor imaging (DTI) and transcranial electrical stimulation (TES), are described, along with their role in studying brain connectivity, white matter tracts, and potential treatments for schizophrenia and chronic pain. Application. The review concludes by examining neuroimaging studies of neurodevelopmental and neurological disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). We also described the role of transcranial direct current stimulation (tDCS) in ASD, ADHD, AD, and PD. Neuroimaging techniques have significantly advanced our understanding of brain function and provided essential insights into neurological disorders. However, further research into noninvasive treatments such as EEG, MRI, and TES is necessary to continue to develop new diagnostic and therapeutic strategies for neurological disorders.

show abstract

Effects of multisite anodal transcranial direct current stimulation combined with cognitive stimulation in patients with Alzheimer's disease and its neurophysiological correlates: A double-blind randomized clinical trial

Cited by 22 publications

References 76 publications

Non-invasive brain stimulation for fatigue in post-acute sequelae of SARS-CoV-2 (PASC)

Non-invasive brain stimulation for fatigue in post-acute sequelae of SARS-CoV-2 (PASC)

The efficacy of combining cognitive training and noninvasive brain stimulation: A transdiagnostic systematic review and meta-analysis.

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

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