Effects of Multispecies Probiotic Combination on Helicobacter pylori Infection In Vitro

Abstract

Probiotic bacteria alleviate many gastrointestinal symptoms, but the current trend of combining bacteria for additional benefit may make their effects more complex. We characterize four probiotics and their combination in terms of pathogen adhesion, barrier function, cell death, and inflammatory response in

Dairy Propionibacteria: Less Conventional Probiotics to Improve the Human and Animal Health

“…freudenreichii strain JS was able to inhibit, alone or combined with other probiotics the adhesion of different pathogens including H .pylori to intestinal mucus and Caco2 cell line also improving the epithelial barrier function [170,185]. Other dairy species like P. acidipropionici strain Q4 was able to prevent the adhesion of Salmonella enteritidis and Escherichia coli to HT29 cells [144] whereas P. acidipropionici CRL 1198 regulates in vitro the growth of Bacteroides and Clostridium in cecal homogenates of mice supplemented with propionibacteria and/or inulin [33].…”

“…Regarding to cytokine production, P. freudenreichii JS was able to induce TNF-α and IL-10 production in human PBMCs [169] and inhibited the H. pylori-induced IL-8 and PGE2 release in human intestinal epithelial cells [170].…”

Three New Lactobacillus plantarum Strains in the Probiotic Toolbox against Gut Pathogen Salmonella enterica Serotype Typhimurium

“…This is a crucial step in colonisation of the gastrointestinal tract and is important for competitive exclusion of enteropathogens (11,12). An important feature is also antagonistic activity against gut pathogens such as Helicobacter pylori, Salmonella spp., Listeria monocytogenes and Clostridium diffi cile (13)(14)(15).…”

The role of probiotics and prebiotics in apoptosis of the gastrointestinal tract

“…Probiotyczne bakterie (Lactobacillus rhamnosus) mają zdolność hamowania właściwości adhezyjnych bakterii Helicobacter pylori, a szczepy bakterii probiotycznych Lactobacillus i Propionibacterium nasilają indukowaną przez bakterię Helicobacter pylori produkcję proapoptotycznej IL-8 [20]. Interleukina 8 jest cytokiną wpływającą na migrację makrofagów i neutrofili.…”

“…[9], Myllyluoma i wsp. [20] oraz Yan i Polk [23]. Bakteria Lactobacillus casei rhamnosus ma zdolność hamowania apoptozy poprzez inhibicję produkcji cytokin proapoptotycznych, takich jak IL-1, IL-6, IL-8 oraz TNF-α [9].…”