Effects of Muscle Strength Training and Megestrol Acetate on Strength, Muscle Mass, and Function in Frail Older People

Abstract

High-intensity PRMST is a safe and well-tolerated exercise regimen for frail elderly patients. The addition of MA appears to blunt the beneficial effects of PRMST, resulting in less muscle strength and functional performance gains.

Effects of Different Exercise Interventions on Risk of Falls, Gait Ability, and Balance in Physically Frail Older Adults: A Systematic Review

“…Among the six studies that did not reveal a significant effect, the study of Barnett et al, 26 used a 1-year, home-based exercise intervention; the authors justified the absence of changes in gait based on the emphasis on balance-related exercises and a low-frequency exercise program. Specific exercises for improving gait were not used in the studies of Latham et al, 33 Sullivan et al, 34 Serra-Rexach et al, 35 (resistance training intervention), Hagedorn and Holm, 29 (resistance training and balance interventions), and Taylor et al 38 (Tai Chi intervention).…”

“…Six studies revealed enhancements in the subjects' gaits after the physical training period, 15,17,23,30,32,36 whereas five studies demonstrated no improvement. 26,[33][34][35]38 Three of the studies that demonstrated improvements in their subjects' gaits used multi-component exercise programs, 15,17,23 two studies used only resistance exercises, 32,35 and one study used endurance training combined with yoga. 36 The mean improvement in gait ranged from 4% to 50%.…”

“…[23][24][25][26]30 Six studies investigated elderly aged 70 and older presenting recent history of injurious falls, transition for frailty, and recent illness-induced functional decline. 17,34,[37][38][39][40] Finally, one study investigated sarcopenic women presenting poor strength and gait ability levels based on literature criteria, 15 and one study investigated elderly aged 90 and older. 35 …”

“…Nine studies revealed increased muscle strength after the physical training period, 23,24,[29][30][31][32]34,35,40 whereas four studies did not identify any improvement. 15,26,28,33 Five of the studies that demonstrated enhanced strength used resistance exercise programs, [30][31][32]34,35 and four studies used multi-component exercise interventions. 23,24,29,40 The mean increase in strength ranged from 6% to 60%.…”

Le vieillissement et l’activité physique : données sur lesquelles fonder des recommandations relatives à l’exercice à l’intention des adultes âgésCet article est tiré d’un supplément intitulé Advancing physical activity measurement and guidelines in Canada: a scientific review and evidence-based foundation for the future of Canadian physical activity guidelines (Favoriser les lignes directrices et la mesure de l’activité physique au Canada: examen scientifique et justification selon les données prob

“…La plupart des études indiquent en fait qu'il faut faire des exercices dont l'intensité varie de modérée à grande (>60 %, 1 RM) afin de maximiser les gains et que 2 jours/semaine produisent autant de bienfaits que 3 jours/semaine à condition que le volume soit semblable (de Vos et al 2005;Fatouros et al 2005;Kalapotharakos et al 2005;Seynnes et al 2004;Smilios et al 2007;Wieser et Haber 2007). L'entraînement de la force contre résistance progressive et de haute intensité est bien toléré même par les adultes âgés frêles (Sullivan et al 2007). Les adultes âgés qui commencent à s'entraîner béné-ficient toutefois de presque n'importe quel programme de surcharge contre résistance progressive (Harris et al 2004).…”