Effects of Myoga on Memory and Synaptic Plasticity by Regulating Nerve Growth Factor-Mediated Signaling

Kim, Hyo Geun; Lim, Soonmin; Ji, Hong; Kim, Ae-Jung; Oh, Myung Sook

doi:10.1002/ptr.5511

Cited by 10 publications

(6 citation statements)

References 26 publications

(42 reference statements)

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“…31,32 NGF is believed to have a great effect on synaptic plasticity, learning, and memory. 33 BDNF is a member of the neurotrophin family, which functions in both embryonic development of the nervous system. 34 Additionally, increased BDNF is able to affect the learning and memory process in hippocampus posthippocampal-dependent cognitive tasks.…”

Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 is involved in sevoflurane‐induced neurotoxicity in developing rats

Hu¹,

Hu²,

Huang³

2019

J of Cellular Biochemistry

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Objective The purpose of this study is to uncover the effects of long chain noncoding RNA (lncRNA) metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) on sevoflurane‐induced neurotoxicity in developing rats. Methods Sevoflurane neurotoxicity model was established by sevoflurane treatment in 7‐day‐old Sprague‐Dawley rats. The rats were treated with Sevo or MALAT1 small interfering RNA to detect the MALAT1 expression, pathological change, ultrastructure, neuronal apoptosis, expression of apoptosis‐related proteins, expression of neurotrophic factors BDNF and NGF, spatial learning and memory function change, as well as neuron cell density of hippocampal tissues. Results MALAT1 was highly expressed in hippocampus tissues of rats. Downregulation of MALAT1 alleviated the pathological change, improved the ultrastructure, inhibited apoptosis of neuronal cells, declined caspase 3 and Bax while elevated Bcl‐2, BDNF and NGF, improved capability of spatial learning and memory, and increased density of hippocampal neurons in hippocampal tissues of sevoflurane‐induced rats. Conclusion Suppression of MALAT1 can reduce the apoptosis of hippocampal neurons induced by sevoflurane anesthesia, improve the capability of spatial learning, and memory function and alleviate the loss of hippocampal nerve cells in developing rats. To a certain extent, it plays the role of protecting brain nerve cells.

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Section: Discussionmentioning

confidence: 99%

LncRNA MALAT1 is involved in sevoflurane‐induced neurotoxicity in developing rats

Hu¹,

Hu²,

Huang³

2019

J of Cellular Biochemistry

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“…The flower bud of Zingiber mioga (Z. mioga) is used medically to alleviate rheumatism in China and is practically used as a health supplement in Eastern Asia (Kim et al, 2015;Lee et al, 2016).…”

Section: Overview Of Empirical Usesmentioning

confidence: 99%

A Study of Genus Zingiber: The Role of Condiments in Science

Paramita

Wibowo

Insanu

2021

CRBB

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Background and purpose: Zingiberaceae family has been widely used as an herbal medicine from generation to generation. This review aimed more in-depth into information and correlation about the empirical uses, bioactive compounds, and biological activities, a literature review genus Zingiber was conducted. Methods: Articles about genus Zingiber were collected from databases (e.g., DOAJ (Directory of Open Access Journal), PubMed, ResearchGate, ScienceDirect, and Springer), they were sorted based on inclusions criteria such as; related to bioactive compounds and biological activities of the samples and also articles for the last ten year. Results: The screening results obtained 52 reports to review and grouped according to each plant's bioactive content and pharmacological effect. The extensive constituent in genus Zingiber is essential oil. Therefore, the major activity found in this genus was related to antimicrobial and anti-oxidant. Furthermore, the other activities of plants were related to their factual use during this time. Conclusion: The empirical uses of these rhizomes were in line with the bioactive compounds and biological activities.

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“…Z. mioga is deeply rooted in Japanese culture and tradition (Gracie et al, 2004). Kim et al (2016) evaluated Z. mioga activity in brain cell cultures prepared from hippocampus of postnatal Sprague-Dawley rats at day 1, focusing especially on the nerve growth factor (NGF), which is believed to mediate synaptic plasticity, supporting learning and memory. In a rat primary hippocampal astrocyte culture system, treatment with Z. mioga extract for 24 h stimulated the production of NGF.…”

Section: Zingiber Bisectum D Fang and Zingiber Rubensmentioning

confidence: 99%

Therapeutic potential of Zingiberaceae in Alzheimer's disease

Bortolucci¹,

Trettel²,

Bernardi³

et al. 2020

BLACPMA

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Alzheimer's disease is the most common form of dementia and is highly prevalent in old age. Unlike current drugs, medicinal plants can have preventive and protective effects with less side effects. Given the great number of bioactive substances, plants from the Zingiberaceae Family have medicinal potential and currently are widely studied regarding its anti-Alzheimer's disease effects. The objective of this study was to provide an overview of advances in phytochemical composition studies, in vitro and in vivo pharmacological studies, and toxicological effects of the Zingiberaceae Family on Alzheimer's disease. Information was obtained from relevant papers in electronic databases. Most of the studies of Zingiberaceae effects on Alzheimer's disease pathogenesis theory are related to cholinergic, β amyloid cascade, tau, inflammation, and oxidative stress hypothesis. Also, in vitro and in vivo preclinical studies on the effect of Alpinia, Curcuma, and Zingiber genera have been reported as harmless and safe, with potential for anti-Alzheimer treatment.

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Effects of Myoga on Memory and Synaptic Plasticity by Regulating Nerve Growth Factor-Mediated Signaling

Cited by 10 publications

References 26 publications

LncRNA MALAT1 is involved in sevoflurane‐induced neurotoxicity in developing rats

LncRNA MALAT1 is involved in sevoflurane‐induced neurotoxicity in developing rats

A Study of Genus Zingiber: The Role of Condiments in Science

Therapeutic potential of Zingiberaceae in Alzheimer's disease

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