Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction

Haberka, Maciej; Mizia-Stec, Katarzyna; Mizia, Magdalena; Gieszczyk, Klaudia; Chmiel, Artur; Sitnik‐Warchulska, Katarzyna; Gąsior, Zbigniew

doi:10.1016/s1734-1140(13)70964-2

Cited by 34 publications

(53 citation statements)

References 40 publications

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“…We (conversely) found greater improvement with a moderately large effect size among patients with comorbid anxiety for both n-3 groups versus placebo. Over a dozen human reports of n-3 fatty acids show anxiolytic effects in substance abusers, 27,28 women with premenstrual syndrome, 29 depressed adults with comorbid anxiety, 30 post-myocardial infarction patients, 31 Japanese with posttraumatic stress disorder, [32][33][34][35][36][37] and young healthy students, 38,39 although not in perimenopausal and postmenopausal women 40 or in older patients. 41,42 Further investigation of n-3 effects on anxiety is warranted.…”

Section: Discussionmentioning

confidence: 99%

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

Mischoulon¹,

Nierenberg²,

Schettler³

et al. 2014

J. Clin. Psychiatry

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Section: Discussionmentioning

confidence: 99%

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

Mischoulon¹,

Nierenberg²,

Schettler³

et al. 2014

J. Clin. Psychiatry

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“…In addition, n-3 PUFA supplementation also decreased depressive and anxiety symptoms in early postmyocardial infarction patients [200], although some studies failed to show any improvement in depressive symptoms among this population [201]. …”

Section: Dietary Content: Focus On N-3 Fatty Acids As Potent Food-mentioning

confidence: 99%

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

2014

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Dietary interventions have emerged as effective environmental inducers of brain plasticity. Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a consistent reduction of total daily food intake), intermittent fasting (IF, every-other-day feeding), and diet supplementation with polyphenols and polyunsaturated fatty acids (PUFAs) on markers of brain plasticity in animal studies. Moreover, we also discuss epidemiological and intervention studies reporting the effects of CR, IF and dietary polyphenols and PUFAs on learning, memory, and mood. In particular, we evaluate the gap in mechanistic understanding between recent findings from animal studies and those human studies reporting that these dietary factors can benefit cognition, mood, and anxiety, aging, and Alzheimer's disease—with focus on the enhancement of structural and functional plasticity markers in the hippocampus, such as increased expression of neurotrophic factors, synaptic function and adult neurogenesis. Lastly, we discuss some of the obstacles to harnessing the promising effects of diet on brain plasticity in animal studies into effective recommendations and interventions to promote healthy brain function in humans. Together, these data reinforce the important translational concept that diet, a modifiable lifestyle factor, holds the ability to modulate brain health and function.

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“…Boosting of standardized antidepressant levels of omega-3 fatty acids results an apparent improvement in symptoms of depression. Improvement of depression symptoms by using fatty acids were found proportional to using potential therapeutic agents such as lithium and lamotrigine 57 . Omega-3 fatty acids such as EPA in comparison to DHA or placebo were observed to be of greater efficacy in adjunctive treatment in mild-to-moderate depression 58, 59…”

Section: More Recent Insights On Omega-3 Fatty Acids and Depressionmentioning

confidence: 99%

Omega-3 fatty acids and the treatment of depression: a review of scientific evidence

Wani

Bhat

Ara

2015

Integrative Medicine Research

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Depression is a condition in which an individual feels lethargic, irritable, and guilty, has difficulty and trouble, no enjoyment in life, mood swings, sometimes suicidal ideation and thoughts, and loss of pleasure in activities. There are hundreds of millions of individuals suffering from major depression disorder all over the world. This leads to a considerable portion of the economy going for treatment as large amounts of money are spent on drugs every year. Pharmaceutical drugs are not very effective and they also have side effects that compound the problem. There are number of studies which shows that omega-3 fatty acids are proving to be very effective against the treatment of major depression disorder and other psychiatric disorders. However, the data regarding the efficacy of omega-3 fatty acids in depression treatment are conflicted. This article reviews the recent research showing the relation between omega-3 fatty acids and depression. The roles of the omega-3 fatty acids in the treatment of depression are being studied with increased pace in the last decade due to heightened prevalence of depression. It is emphasized that omega-3 fatty acids have no record of associated side effects, which deserves greater attention for further research.

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Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction

Abstract: Our study provides novel and preliminary observations--n-3 PUFA supplementation reveals additional decreasing effects on depressive and anxiety symptoms in early post-MI patients.

Cited by 34 publications

References 40 publications

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

A Double-Blind, Randomized Controlled Clinical Trial Comparing Eicosapentaenoic Acid Versus Docosahexaenoic Acid for Depression

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

Omega-3 fatty acids and the treatment of depression: a review of scientific evidence

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