Effects of n-3 polyunsaturated fatty acid supplementation on cognitive functions, electrocortical activity and neurogenesis in a non-human primate, the grey mouse lemur (Microcebus murinus)

Royo, Julie; Villain, Nicolas; Champeval, Delphine; Gallo, Federico Del; Bertini, Giuseppe; Aujard, Fabienne; Pifferi, Fabien

doi:10.1016/j.bbr.2018.02.029

Cited by 19 publications

(16 citation statements)

References 67 publications

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“…Regarding cognitive outcomes, only seven animals reached the success criterion to the learning task, which is one-third of the total number of individuals. This result may seem low but it lies close to the success rate observed in other experiments using the same cognitive apparatus (Picq et al, 2015; Royo et al, 2018). The resulting interpretations must though be viewed cautiously.…”

Section: Discussionsupporting

confidence: 84%

Physiological and cognitive consequences of a daily 26h photoperiod in a primate(M. murinus)

Hozer

Pifferi

2020

Preprint

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Daily resetting of the circadian clock to the 24h natural photoperiod might induce marginal costs that would accumulate over time and forward affect fitness. It was proposed as the circadian resonance theory by Pittendrigh in 1972. For the first time, we aimed to evaluate these physiological and cognitive costs that would partially explain the mechanisms of the circadian resonance hypothesis. We evaluated the potential costs of imposing a 26h photoperiodic regimen compared to the classical 24h entrainment measuring several physiological and cognitive parameters (body temperature, energetic expenditure, oxidative stress, cognitive performances). We found significant higher resting body temperature and energy expenditure and lower cognitive performances when the photoperiodic cycle length was 26h. Together these results suggest that a great deviation of external cycles from 24h leads to daily greater synchronization costs, and lower cognitive capacities. To our knowledge, this study is the first to highlight potential mechanisms of circadian resonance theory.

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Section: Discussionsupporting

confidence: 84%

Physiological and cognitive consequences of a daily 26h photoperiod in a primate(M. murinus)

Hozer

Pifferi

2020

Preprint

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“…In addition, since anxiety varies throughout aging, including in lemurs, in which it decreases with age (see Anxiety Section), we assessed the impact of 5 months of ω3 PUFA supplementation on behavioral parameters including exploratory activity, emotional status, and spatial memory in old animals (Languille et al, 2012a). Aged ω3 PUFA-supplemented animals exhibited no change in anxiety levels measured in the open field task, in contrast to young animals (Vinot et al, 2011; Pifferi et al, 2015; Royo et al, 2018), confirming the specificity of the anxiety response in aged animals in this species.…”

Section: Interventions Mimicking Bpsd/studying Bpsd Markersmentioning

confidence: 52%

“…These results were linked to better glucose transport to the brain (Pifferi et al, 2015). In a more recent study, supplementation in young adults lasted 21 months and showed a similar conclusion of reduced anxiety in various cognitive tasks, including the open field task (Royo et al, 2018). Interestingly, in addition to better glucose uptake to the brain, we were able to measure increased neurogenesis in associated cerebral regions (including the amygdala).…”

Section: Interventions Mimicking Bpsd/studying Bpsd Markersmentioning

confidence: 73%

“…Overall, these findings are in accordance with observations made in other anxiety-related situations, such as the open field test. In a study by Languille and colleagues (Languille et al, 2015), the latency to the first movement in the open field, a parameter recognized as a marker of anxiety (Dal-Pan et al, 2011; Royo et al, 2018), differed significantly with age. In this task (the open field test adapted for mouse lemurs, consisting of an empty squared box of 1 × 1 m), old animals started exploring earlier than middle-aged and young animals, confirming a decrease in novelty-related anxiety in old animals compared to young animals.…”

Section: Potential Markers Of Behavioral and Psychological Symptoms Omentioning

confidence: 98%

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Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

2019

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To face the load of the prevalence of Alzheimer’s disease in the aging population, there is an urgent need to develop more translatable animal models with similarities to humans in both the symptomatology and physiopathology of dementia. Due to their close evolutionary similarity to humans, non-human primates (NHPs) are of primary interest. Of the NHPs, to date, the gray mouse lemur (Microcebus murinus) has shown promising evidence of its translatability to humans. The present review reports the known advantages and limitations of using this species at all levels of investigation in the context of neuropsychiatric conditions. In this easily bred Malagasy primate with a relatively short life span (approximately 12 years), age-related cognitive decline, amyloid angiopathy, and risk factors (i.e., glucoregulatory imbalance) are congruent with those observed in humans. More specifically, analogous behavioral and psychological symptoms and neuropsychiatric symptoms of dementia (BPSD/NPS) to those in humans can be found in the aging mouse lemur. Aged mouse lemurs show typical age-related alterations of locomotor activity daily rhythms such as decreased rhythm amplitude, increased fragmentation, and increased activity during the resting-sleeping phase of the day and desynchronization with the light-dark cycle. In addition, sleep deprivation successfully induces cognitive deficits in adult mouse lemurs, and the effectiveness of approved cognitive enhancers such as acetylcholinesterase inhibitors or N-methyl-D-aspartate antagonists is demonstrated in sleep–deprived animals. This result supports the translational potential of this animal model, especially for unraveling the mechanisms underlying dementia and for developing novel therapeutics to prevent age-associated cognitive decline. In conclusion, actual knowledge of BPSD/NPS-like symptoms of age-related cognitive deficits in the gray mouse lemur and the recent demonstration of the similarity of these symptoms with those seen in humans offer promising new ways of investigating both the prevention and treatment of pathological aging.

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“…Surgical implantations were conducted in conditions of sterility, under veterinarian supervision. The surgical procedure was previously described in several references (Pifferi et al, 2012; Royo et al, 2018). The epidural electrode tips were placed over the PFC (2–3 mm from the midline and 7.5 mm anterior to the interneural line, corresponding to the transversal section shown in plate 33 of the “Stereotaxic atlas of the brain gray mouse lemur” Bons et al, 1998), and EMG electrode wires were placed on the neck muscles with a non-absorbable polyamine suture.…”

Section: Methodsmentioning

confidence: 99%

Daily Torpor and Sleep in a Non-human Primate, the Gray Mouse Lemur (Microcebus murinus)

2019

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Daily torpor is an energy-saving process that evolved as an extension of non-rapid eye movement (NREM) sleep mechanisms. In many heterothermic species there is a relation between torpor expression and the repartition of the different behavioral states of sleep. Despite the presence of sleep during this period of hypothermia, torpor induces an accumulation of sleep debt which results in a rebound of sleep in mammals. We aimed to investigate the expression of sleep-wake rhythms and delta waves during daily torpor at various ambient temperatures in a non-human primate model, the gray mouse lemur (Microcebus murinus). Cortical activity was measured with telemetric electroencephalography (EEG) recordings in the prefrontal cortex (PFC) during the torpor episode and the next 24 h following hypothermia. Gray mouse lemurs were divided into two groups: the first group was subjected to normal ambient temperatures (25°C) whereas the second group was placed at lower ambient temperatures (10°C). Contrary to normal ambient temperatures, sleep-wake rhythms were maintained during torpor until body temperature (Tb) of the animals reached 21°C. Below this temperature, NREM and REM sleep strongly decreased or were absent whereas the EEG became isoelectric. The different states of sleep were proportional to Tbmin during prior torpor in contrast to active phases. Delta waves increased after torpor but low Tb did not induce greater delta power compared to higher temperatures. Our results showed that Tb was a determining factor for the quality and quantity of sleep. Low Tb might be inconsistent with the recovery function of sleep. Heterothermy caused a sleep debt thus there was a rebound of sleep at the beginning of euthermia to compensate for the lack of sleep.

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Effects of n-3 polyunsaturated fatty acid supplementation on cognitive functions, electrocortical activity and neurogenesis in a non-human primate, the grey mouse lemur (Microcebus murinus)

Cited by 19 publications

References 67 publications

Physiological and cognitive consequences of a daily 26h photoperiod in a primate(M. murinus)

Physiological and cognitive consequences of a daily 26h photoperiod in a primate(M. murinus)

Strengths and Weaknesses of the Gray Mouse Lemur (Microcebus murinus) as a Model for the Behavioral and Psychological Symptoms and Neuropsychiatric Symptoms of Dementia

Daily Torpor and Sleep in a Non-human Primate, the Gray Mouse Lemur (Microcebus murinus)

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