Effects of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease

Uzun, Mehmet; Köksal, Neşet; Kadıoğlu, Hüseyin; Günerhan, Yusuf; Aktas, Suat; Dursun, Nevra; Şehirli, Ahmet Özer

doi:10.1007/s00595-008-3930-4

Cited by 23 publications

(22 citation statements)

References 28 publications

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“…This is in compliance with our study in terms of positive effects of vitamin E on regeneration (20). In a study on damaged rat liver with acetaminophen conducted by Kostopanagiotou and his colleagues, the triggering effect of propofol on the rate of regeneration was found statistically insignificant (21). In our experimental study, after hepatectomy, propofol's positive contribution to the regeneration has been confi rmed.…”

Section: Discussionsupporting

confidence: 73%

The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver

Yormaz

Bülbüloğlu²,

Kurutaş³

et al. 2012

BLL

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Aim:We investigated the comparison of the effects of N-acetylcysteine, silybum marinaum, propofol, and vitamin E on liver hepatic regeneration after partial hepatectomy. Method: Forty-eight rats were randomized into 6 different groups of the same age and weight. After partial hepatectomy, all animals were resuscitated with 5 ml of isotonic sodium chloride solution administered subcutaneously while group 1 (sham) did not receive any injection, group 2 (control) received serum physiologic intraperitoneally, group 3 received 25 mg /kg of propofol intraperitoneally, group 4 received 20 mg/kg of N-acetylcysteine intraperitoneally, group 5 received 400 mg/kg of vitamin E intraperitoneally, and group 6 received 10 mg/kg of silybum intraperitoneally. None of these groups were given antibitotics. On the third day, a half of the rats, and on the seventh day, the other half of rats were reoperated and sacrifi ced. Results: Blood samples were used for biochemical parameters (AST, ALT). Ki-67 proliferation index was used for histopathologic parameters. A statistically meaningful difference was detected in silybum, vitamin E, N-acetylcysteine, and propofol groups for AST, ALT levels when compared to control and sham groups (p<0.05). Ki-67 regeneration proliferation index of all groups, which were given agents on the third and seventh days were statistically higher than the control and sham groups (p<0.05). During the evaluation, AST, ALT, Ki-67, Ro (regeneration value) levels of silybum group displayed a statistically signifi cant difference according to other groups (p<0.05). Conclusion: Our experimental study indicates that hepatic regeneration after partial hepatectomy was meaningful and signifi cant in groups with intraperitoneal administration of silybum marinaum,vitamin E, N-acetylcysteine and propofol. Hepatic regeneration rate was particularly higher in silybum group compared to other groups (Fig. 16 The liver is the largest internal organ of the human body. It has important roles in regulating the metabolic functions, and in the immune system. After resection or traumatic injury, the liver is a single organ capable of fast tissue regeneration. In order to maintain the existing liver functions after liver resection, the period and effect of hepatic ischemia before and during the resection should be reduced to minimum,. Besides, after the resection, the increase in hepatic blood fl ow and the reduction of infl ammatory events are currently getting increasingly important.The postoperative mortality rate in liver resection depends directly on preoperative liver functions and liver resection volume.

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Section: Discussionsupporting

confidence: 73%

The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver

Yormaz

Bülbüloğlu²,

Kurutaş³

et al. 2012

BLL

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“…(31,32) Primary nonfunction incidences of 1.8% and 5.1% were reported following transplantation of nonsteatotic grafts and grafts with macrovesicular steatosis greater than 30%, respectively. (33) In contrast, grafts with up to 30% steatosis had similar PNF indices compared to nonsteatotic grafts. (32) Grafts with moderate steatosis (30-59%) can be used, provided they are well allocated to recipients (i.e., recipients free from other risk factors).…”

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 96%

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Neves

Rusi

Díaz

et al. 2016

Einstein (São Paulo)

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Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" and "liver transplantation". Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery-and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.

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“…The proinflammatory, pro-fibrogenic effects of the aldehyde end-products of lipid peroxidation (MDA and 4-hydroxynonenol) potentially account for all of the typical histological features observed in NAFLD [34] . It has been shown that MDA, an index of lipid peroxidation and oxidative stress, damages cells and tissues.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats

et al. 2012

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Aim: To study the protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats. Methods: Male Sprague-Dawley rats were given a high-fat diet for 10 weeks. The rats were administered tiopronin (20 mg/kg) or a positive control drug ursodeoxycholic acid (UDCA, 15 mg/kg) via gavage daily from week 5 to week 10. After the rats were sacrificed, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglyceride (TG), free fatty acids (FFA), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C), and liver homogenate FFA, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured using commercial analysis kits. The expression levels of CYP2E1 mRNA and protein were determined using RT-PCR and immunoblot assays, respectively. Results: Tiopronin significantly lowered both the serum ALT and AST levels, while only the serum ALT level was lowered by UDCA. Tiopronin significantly decreased the serum and liver levels of TG, TC and FFA as well as the serum LDL-C level, and increased the serum HDL-C level, while UDCA decreased the serum and liver TC levels as well as the serum LDL-C level, but did not change the serum levels of TG, FFA and HDL-C. Tiopronin apparently ameliorated the hepatocyte degeneration and the infiltration of inflammatory cells in the livers, but UDCA did not affect the pathological features of the livers. Both tiopronin and UDCA ameliorated the mitochondrial abnormality in the livers. The benefits of tiopronin were associated with increased SOD and GSH-Px activities, and with decreased MDA activity and CYP2E1 expression in the livers. Conclusion: Tiopronin exerts protective effects against non-alcoholic steatohepatitis in rats, which may be associated with its antioxidant properties and regulation of lipid metabolism.

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Effects of N-acetylcysteine on regeneration following partial hepatectomy in rats with nonalcoholic fatty liver disease

Abstract: N-Acetylcysteine enhanced regeneration after partial hepatectomy in rats with NAFLD. We believe that it exerted this effect through its influence on oxidative stress.

Cited by 23 publications

References 28 publications

The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver

The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Protective effects of tiopronin against high fat diet-induced non-alcoholic steatohepatitis in rats

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