Effects of N-acetylcysteine on the erythrocyte and liver cholinesterase, nitric oxide and malondialdehyde levels in acute organophosphate toxicity

Bayır, Ayşegül; Kara, Hanife; Köylü, Öznur; Kocabaş, Rahim; Ak, Ahmet

doi:10.1186/cc9786

Cited by 2 publications

(3 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…There has even been some evidence that NO generation might have some immunomodulating effects on MS. 52 Several studies reported a significant decrease in NO levels using GSH 53 or NAC. 54 , 55 , 56 However, most of the studies on the effect of NAC on NO levels were animal studies. Sabetghadam et al reported that high‐dose NAC administration in 68 patients with acute ischemic stroke resulted in significantly decreased serum levels of NO.…”

Section: Discussionmentioning

confidence: 99%

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Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Mohseni

Hosseini

Majdinasab

et al. 2023

Neuropsychopharm Rep

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AimN‐acetylcysteine (NAC), a thiol‐containing antioxidant and glutathione (GSH) precursor, attenuates oxidative stress, and possibly improves psychiatric disorders. This study aimed to evaluate the effects of oral NAC on oxidative stress, depression, and anxiety symptoms in patients with multiple sclerosis (MS).MethodsThis clinical trial was conducted on 42 MS patients randomly assigned to intervention (n = 21) and control (n = 21) groups. The intervention group received 600 mg of NAC twice daily for 8 weeks, and the control group received a placebo with the same prescription form. An analysis of serum malondialdehyde (MDA), serum nitric oxide (NO), and erythrocyte GSH was carried out on both groups, along with a complete blood count. The Hospital Anxiety and Depression Scale (HADS) was used to assess symptoms of depression (HADS‐D) and anxiety (HADS‐A).ResultsCompared to the control group, NAC consumption significantly decreased serum MDA concentrations (−0.33 [−5.85–2.50] vs. 2.75 [−0.25–5.22] μmol/L; p = 0.03) and HADS‐A scores (−1.6 ± 2.67 vs. 0.33 ± 2.83; p = 0.02). No significant changes were observed in serum NO concentrations, erythrocyte GSH levels, and HADS‐D scores (p > 0.05).ConclusionsBased on the findings of the present study, NAC supplementation for 8 weeks decreased lipid peroxidation and improved anxiety symptoms in MS patients. The aforementioned results suggest that adjunctive therapy with NAC can be considered an effective strategy for MS management. Further randomized controlled studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Mohseni

Hosseini

Majdinasab

et al. 2023

Neuropsychopharm Rep

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“…A report from Yurumez et al [ 87 ] demonstrated that N-acetylcysteine could rescue antioxidative glutathione, nitrite and nitrate and decrease MDA generation in organophosphate-treated mice. The study conducted by Bayir et al [ 88 ] demonstrated that in organophosphate-poisoned mice, n-acetylcysteine alone could restore the cholinesterase concentration within erythrocytes, and the liver MDA level was lessened in n-acetylcysteine-treated mice rather than pralidoxime-atropine-treated mice or sham mice. From the aspect of decreasing organophosphate-mediated oxidative stress and the sequential development of diabetes mellitus, a therapeutic strategy for lowering ROS should be considered.…”

Section: Role Of Ros Generation In Organophosphate-mediated New-onset Diabetes Mellitusmentioning

confidence: 99%

Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective

Chung¹,

Hou²,

Wang³

et al. 2021

WJD

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Organophosphate is a commonly used pesticide in the agricultural sector. The main action of organophosphate focuses on acetylcholinesterase inhibition, and it therefore contributes to acute cholinergic crisis, intermediate syndrome and delayed neurotoxicity. From sporadic case series to epidemiologic studies, organophosphate has been linked to hyperglycemia and the occurrence of new-onset diabetes mellitus. Organophosphate-mediated direct damage to pancreatic beta cells, insulin resistance related to systemic inflammation and excessive hepatic gluconeogenesis and polymorphisms of the enzyme governing organophosphate elimination are all possible contributors to the development of new-onset diabetes mellitus. To date, a preventive strategy for organophosphate-mediated new-onset diabetes mellitus is still lacking. However, lowering reactive oxygen species levels may be a practical method to reduce the risk of developing hyperglycemia.

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Effects of N-acetylcysteine on the erythrocyte and liver cholinesterase, nitric oxide and malondialdehyde levels in acute organophosphate toxicity

Cited by 2 publications

References 0 publications

Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Effects of N‐acetylcysteine on oxidative stress biomarkers, depression, and anxiety symptoms in patients with multiple sclerosis

Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective

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