Effects of NaHS and hydroxylamine on the expressions of brain-derived neurotrophic factor and its receptors in rats after cardiac arrest and cardiopulmonary resuscitation

Lin, Jia Wei; Wu, Wei; Xu, Zhijian; Liu, Siyao; Wang, Lu; Pan, Mandong

doi:10.1186/s13049-018-0577-z

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…37 The observed therapeutic benefits were associated with anti-apoptotic, anti-inflammatory, and antioxidative mechanisms. Modulating the endogenous H2S level in the 6-minute ventricular fibrillation rat CA model by IV injection of 1 mL sodium hydrosulfide (NaHS) at 14 μmol/kg•d, 1 hour post-ROSC, increased the rat survival, 38 upregulating neurotrophic factors including brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase β in the brain tissue.…”

Section: Preclinical Evidencementioning

confidence: 99%

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Marasini,

Jia

2024

J Stroke

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With the implementation of improved bystander cardiopulmonary resuscitation techniques and public-access defibrillation, survival after out-of-hospital cardiac arrest (OHCA) has increased significantly over the years. Nevertheless, OHCA survivors have residual anoxia/reperfusion brain damage and associated neurological impairment resulting in poor quality of life. Extracorporeal membrane oxygenation or targeted temperature management has proven effective in improving post-cardiac arrest (CA) neurological outcomes, yet considering the substantial healthcare costs and resources involved, there is an urgent need for alternative treatment strategies that are crucial to alleviate brain injury and promote recovery of neurological function after CA. In this review, we searched PubMed for the latest preclinical or clinical studies (2016–2023) utilizing gas-mediated, pharmacological, or stem cell-based neuroprotective approaches after CA. Preclinical studies utilizing various gases (nitric oxide, hydrogen, hydrogen sulfide, carbon monoxide, argon, and xenon), pharmacological agents targeting specific CA-related pathophysiology, and stem cells have shown promising results in rodent and porcine models of CA. Although inhaled gases and several pharmacological agents have entered clinical trials, most have failed to demonstrate therapeutic effects in CA patients. To date, stem cell therapies have not been reported in clinical trials for CA. A relatively small number of preclinical stem-cell studies with subtle therapeutic benefits and unelucidated mechanistic explanations warrant the need for further preclinical studies including the improvement of their therapeutic potential. The current state of the field is discussed and the exciting potential of stem-cell therapy to abate neurological dysfunction following CA is highlighted.

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Section: Preclinical Evidencementioning

confidence: 99%

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Marasini,

Jia

2024

J Stroke

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“…H 2 S has been referred as a neuromodulator and neuroprotectant in the central nervous system, produces anti-oxidant, anti-inflammatory, and anti-apoptotic effects in cerebral injury [ 16 , 17 ]. In the field of CA and CPR, research of H 2 S in cerebral injury after CA has gradually increased [ 18 – 20 ]. Geng et al demonstrated H 2 S improved the integrity of BBB, mitigated brain edema; improved neurological outcome and 14-days survival rate in rats after CA and resuscitation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Hypothermia Combined with Hydrogen Sulfide Treatment Attenuated Early Blood–Brain Barrier Disruption and Brain Edema Induced by Cardiac Arrest and Resuscitation in Rat Model

Cai

Fan

et al. 2022

Neurochem Res

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Brain injury remains a major problem in patients suffering cardiac arrest (CA). Disruption of the blood–brain barrier (BBB) is an important factor leading to brain injury. Therapeutic hypothermia is widely accepted to limit neurological impairment. However, the efficacy is incomplete. Hydrogen sulfide (H2S), a signaling gas molecule, has protective effects after cerebral ischemia reperfusion injury. This study showed that combination of hypothermia and H2S after resuscitation was more beneficial for attenuated BBB disruption and brain edema than that of hypothermia or H2S treatment alone. CA was induced by ventricular fibrillation for 4 min. Hypothermia was performed by applying alcohol and ice bags to the body surface under anesthesia. We used sodium hydrosulphide (NaHS) as the H2S donor. We found that global brain ischemia induced by CA and cardiopulmonary resuscitation (CPR) resulted in brain edema and BBB disruption; Hypothermia or H2S treatment diminished brain edema, decreased the permeability and preserved the structure of BBB during the early period of CA and resuscitation, and more importantly, improved the neurologic function, increased the 7-day survival rate after resuscitation; the combination of hypothermia and H2S treatment was more beneficial than that of hypothermia or H2S treatment alone. The beneficial effects were associated with the inhibition of matrix metalloproteinase-9 expression, attenuated the degradation of the tight junction protein occludin, and subsequently protected the structure of BBB. These findings suggest that combined use of therapeutic hypothermia and hydrogen sulfide treatment during resuscitation of CA patients could be a potential strategy to improve clinical outcomes and survival rate.

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“…H 2 S has been referred as a neuromodulator and neuroprotectant in the central nervous system, produces anti-oxidant, anti-in ammatory, and anti-apoptotic effects in cerebral ischemia reperfusion injury, and in the eld of CPR, the research of H 2 S in cerebral resuscitation after CA has gradually increased. [5,[17][18][19]. Geng et al demonstrated H 2 S improved the integrity of BBB, mitigated brain edema; improved neurological outcome and 14-days survival rate in rats after CA and resuscitation [5].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic hypothermia combined with hydrogen sulfide treatment attenuated early blood–brain barrier disruption and brain edema induced by cardiac arrest and resuscitation in rat model

Cai

Fan

et al. 2022

Preprint

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Brain injury remains a major problem in patients suffering cardiac arrest (CA). Disruption of the blood-brain barrier (BBB) is an important factor leading to brain injury. Therapeutic hypothermia is widely accepted to limit neurological impairment. However, the efficacy is incomplete. Hydrogen sulfide (H2S), a signaling gas molecule, has protective effects after cerebral ischemia/reperfusion injury. This study showed that combination of therapeutic hypothermia and hydrogen sulfide after resuscitation was more beneficial for attenuated BBB disruption and brain edema than that of hypothermia or hydrogen sulfide treatment alone. CA was induced by ventricular fibrillation for 4 minutes. Therapeutic hypothermia was performed by applying alcohol and ice bags to the body surface under anesthesia. We used sodium hydrosulphide (NaHS) as the H2S donor. Here, we found that global brain ischemia induced by CA and CPR resulted in brain edema and BBB disruption; therapeutic hypothermia or H2S treatment diminished brain edema, decreased the permeability and preserved the structure of BBB during the early period of CA and resuscitation, and more importantly, improved the neurologic function, increased the 7-day survival rate after resuscitation; the combination of therapeutic hypothermia and H2S treatment was more beneficial for reducing BBB permeability and brain edema than that of hypothermia or H2S treatment alone. The beneficial effects were associated with the inhibition of matrix metalloproteinase-9 (MMP-9) expression, attenuated the degradation of the tight junction protein occludin, and subsequently protected the structure of BBB. These findings suggest that combined use of hypothermia and H2S treatment during resuscitation of cardiac arrest patients could be a potential strategy to improve clinical outcomes and survival rate.

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Effects of NaHS and hydroxylamine on the expressions of brain-derived neurotrophic factor and its receptors in rats after cardiac arrest and cardiopulmonary resuscitation

Cited by 3 publications

References 40 publications

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Neuroprotective Approaches for Brain Injury After Cardiac Arrest: Current Trends and Prospective Avenues

Therapeutic Hypothermia Combined with Hydrogen Sulfide Treatment Attenuated Early Blood–Brain Barrier Disruption and Brain Edema Induced by Cardiac Arrest and Resuscitation in Rat Model

Therapeutic hypothermia combined with hydrogen sulfide treatment attenuated early blood–brain barrier disruption and brain edema induced by cardiac arrest and resuscitation in rat model

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