Effects of nanoparticles on the mechanical functioning of the lung

Arick, Davis Q.; Choi, Yeon-Seok; Kim, Hyeon Chang; Won, You‐Yeon

doi:10.1016/j.cis.2015.10.002

Cited by 78 publications

(68 citation statements)

References 41 publications

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“…This is particularly important because several studies have shown that particles can interact with fluid layers, altering their composition, lateral organization, and physico-chemical properties, especially the rheological one [15][16][17][18][19]. Therefore, the understanding of the interaction of particles with lung surfactant models is particularly important because it can help to deepen the potential impact of inhaled particles on the properties of this system, which may be useful as a preliminary tool for the evaluation of the potential toxicity of inhaled particles [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…The complexity of the lung surfactant system makes it difficult to study the particles' impact in their performance using in vivo assays, which imposes the use of simple physico-chemical models for helping in the understanding of the potential toxicity of inhaled particles [20,24]. Thus, considering that the performance of lung surfactant is associated with their adsorption as a thin film at the interfacial region existing between the alveolar fluid overlaying the alveolar inner wall and the air contained in alveoli, the Langmuir monolayer at water/vapor interfaces may be considered as a useful tool for deepening the physico-chemical bases underlying the mechanical function of the lung surfactant layer, and the impact of the incorporation of nanoparticles on its performance [20,21,24]. Furthermore, the chemical complexity of lung surfactant makes it necessary to reduce the number of chemical species included in the used model to deepen the role of each single component in the interfacial properties of the lung surfactant layer and to understand how nanoparticles modify its performance.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

et al. 2020

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Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

et al. 2020

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“…[18][19][20][21][22][23][24][25][26][27] However, due to the multi-component of PSM and environmental complexity, these results have been controversial. [18][19][20][21][22][23][24][25][26][27] However, due to the multi-component of PSM and environmental complexity, these results have been controversial.…”

Section: Introductionmentioning

confidence: 99%

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Yue

et al. 2016

Phys. Chem. Chem. Phys.

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Increasing evidence indicates that carbon nanoparticles (CNPs), which mainly originate from incomplete combustion of fossil fuels, have an adverse impact on the respiratory system. Recent in vivo experiments have shown that the pulmonary toxicity of CNPs is attributed to their aggregation in pulmonary surfactant monolayers (PSMs) while the underlying mechanism of aggregation remains unclear. Here, by performing coarse grained molecular dynamics simulations, we demonstrate for the first time that the aggregation of carbon nanospheres (CNSs) in PSMs is in fact size-dependent and mediated by lipid extractions. Upon CNS deposition, neighbouring lipid molecules are extracted from PSMs to cover CNSs from the top side. The extracted lipids induce clustering of CNSs to maximize the CNS-lipid interaction, by forming inverse micelles to wrap the aggregated CNSs cooperatively. The formed CNS clusters perturb the molecule structure of the PSM and thus affect its biofunction on respiration. Our simulations show that during the expiration process, CNSs form clusters that perturb the mechanical properties of the PSM in a manner depending on the CNS size. With deep inspiration, a high concentration of large CNSs may induce PSM rupture and thus have a potential impact on its biophysical properties.

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“…The majority of surfactant lipids are phosphatidylcholines (PC) ($80%) that are essential for the maintenance of low surface tension in alveoli (Arick et al, 2015). In addition to the recycling of surfactant described above, an important portion of the PC arises from the synthesis in ATII cells.…”

Section: Introductionmentioning

confidence: 99%

“…In the lungs, NPs have versatile interactions with pulmonary cells that can lead to various adverse effects (Arick et al, 2015). In the alveoli, NPs come in contact with the surfactant film, resulting in the coating of NPs with surfactant, and thereafter with alveolar macrophages and the epithelium.…”

Section: Introductionmentioning

confidence: 99%

Harmful at non-cytotoxic concentrations: SiO₂-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells

et al. 2017

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The pulmonary delivery of nanoparticles (NPs) is a promising approach in nanomedicine. For the efficient and safe use of inhalable NPs, understanding of NP interference with lung surfactant metabolism is needed. Lung surfactant is predominantly a phospholipid substance, synthesized in alveolar type II cells (ATII), where it is packed in special organelles, lamellar bodies (LBs). In vitro and in vivo studies have reported NPs impact on surfactant homeostasis, but this phenomenon has not yet been sufficiently examined. We showed that in ATII-like A549 human lung cancer cells, silica-coated superparamagnetic iron oxide NPs (SiO 2 -SPIONs), which have a high potential in medicine, caused an increased cellular amount of acid organelles and phospholipids. In SiO 2 -SPION treated cells, we observed elevated cellular quantity of multivesicular bodies (MVBs), organelles involved in LB biogenesis. In spite of the results indicating increased surfactant production, the cellular quantity of LBs was surprisingly diminished and the majority of the remaining LBs were filled with SiO 2 -SPIONs. Additionally, LBs were detected inside abundant autophagic vacuoles (AVs) and obviously destined for degradation. We also observed time-and dose-dependent changes in mRNA expression for proteins involved in lipid metabolism. Our results demonstrate that non-cytotoxic concentrations of SiO 2 -SPIONs interfere with surfactant metabolism and LB biogenesis, leading to disturbed ability to reduce hypophase surface tension. To ensure the safe use of NPs for pulmonary delivery, we propose that potential NP interference with LB biogenesis is obligatorily taken into account. ARTICLE HISTORY

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Effects of nanoparticles on the mechanical functioning of the lung

Cited by 78 publications

References 41 publications

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Harmful at non-cytotoxic concentrations: SiO₂-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells

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Effects of nanoparticles on the mechanical functioning of the lung

Cited by 78 publications

References 41 publications

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Lipid extraction mediates aggregation of carbon nanospheres in pulmonary surfactant monolayers

Harmful at non-cytotoxic concentrations: SiO2-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells

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Harmful at non-cytotoxic concentrations: SiO₂-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells