Effects of narcotics, including morphine, on visual evoked potential in rats

Kuroda, Ken; Fujiwara, Akinori; Takeda, Yasuhiro; Kamei, Chiaki

doi:10.1016/j.ejphar.2008.11.048

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…The VEPs can provide important diagnostic information about the functional integrity of the visual system. The surgical process is similar to the method described previously [28], [39], [40]. The animals were anesthetized and fixed to stereotaxic apparatus.…”

Section: Methodsmentioning

confidence: 99%

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

et al. 2014

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BackgroundInhibitory factors have been implicated in the failure of remyelination in demyelinating diseases. Myelin associated inhibitors act through a common receptor called Nogo receptor (NgR) that plays critical inhibitory roles in CNS plasticity. Here we investigated the effects of abrogating NgR inhibition in a non-immune model of focal demyelination in adult mouse optic chiasm.Methodology/Principal FindingsA focal area of demyelination was induced in adult mouse optic chiasm by microinjection of lysolecithin. To knock down NgR levels, siRNAs against NgR were intracerebroventricularly administered via a permanent cannula over 14 days, Functional changes were monitored by electrophysiological recording of latency of visual evoked potentials (VEPs). Histological analysis was carried out 3, 7 and 14 days post demyelination lesion. To assess the effect of NgR inhibition on precursor cell repopulation, BrdU was administered to the animals prior to the demyelination induction. Inhibition of NgR significantly restored VEPs responses following optic chiasm demyelination. These findings were confirmed histologically by myelin specific staining. siNgR application resulted in a smaller lesion size compared to control. NgR inhibition significantly increased the numbers of BrdU+/Olig2+ progenitor cells in the lesioned area and in the neurogenic zone of the third ventricle. These progenitor cells (Olig2+ or GFAP+) migrated away from this area as a function of time.Conclusions/SignificanceOur results show that inhibition of NgR facilitate myelin repair in the demyelinated chiasm, with enhanced recruitment of proliferating cells to the lesion site. Thus, antagonizing NgR function could have therapeutic potential for demyelinating disorders such as Multiple Sclerosis.

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Section: Methodsmentioning

confidence: 99%

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

et al. 2014

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“…Human subjects can undergo VEP recording in awake state ( Holder et al., 2010 ), whereas small animals, such as rodents, generally need anaesthesia to better control stimuli presentation, avoid movements and minimize external noise sources. Different types of anaesthetics or sedatives have been used to perform VEPs in animals, such as halothane ( Imas et al., 2004 ), sevoflurane ( Castoldi et al., 2020 ), isoflurane ( Aggarwal et al., 2019 ), urethane ( Porciatti et al., 1999 ), ketamine-xylazine ( Roth et al., 2018 ; Land et al., 2019 ), pentobarbital ( Maertz et al., 2006 ), fentanyl ( Kuroda et al., 2009 ), detomidine ( Ström and Ekesten, 2016 ), chloral hydrate ( Siegel et al., 1993 ), and morphine ( Kuroda et al., 2009 ). The focus of this work is the examination of VEP property changes depending on two types of anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive visual evoked potentials under sevoflurane versus ketamine-xylazine in rats

Castoldi

d’Isa²,

Marenna³

et al. 2021

Heliyon

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“…Besides, there is another study indicating that morphine plays an analgesic role through stimulating the retina–geniculate–cortex pathway and the thalamus–cortex circuit by regulating the opioid receptors. 84 …”

Section: Brain Regions and Circuits Associated With Photoanalgesiamentioning

confidence: 99%

“…5 To verify the role of this pathway in their study, they inhibited the retina-IGL/vLGN pathway and completely abolished the analgesic effects, which showed that the retina-IGL/vLGN pathway is responsible for the green light Besides, there is another study indicating that morphine plays an analgesic role through stimulating the retina-geniculatecortex pathway and the thalamus-cortex circuit by regulating the opioid receptors. 84…”

Section: Intergeniculate Leaflet/lateral Geniculate Nucleusmentioning

confidence: 99%

Looking for a Beam of Light to Heal Chronic Pain

Xu,

Zhang,

Chen

et al. 2024

JPR

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Chronic pain (CP) is a leading cause of disability and a potential factor that affects biological processes, family relationships, and self-esteem of patients. However, the need for treatment of CP is presently unmet. Current methods of pain management involve the use of drugs, but there are different degrees of concerning side effects. At present, the potential mechanisms underlying CP are not completely clear. As research progresses and novel therapeutic approaches are developed, the shortcomings of current pain treatment methods may be overcome. In this review, we discuss the retinal photoreceptors and brain regions associated with photoanalgesia, as well as the targets involved in photoanalgesia, shedding light on its potential underlying mechanisms. Our aim is to provide a foundation to understand the mechanisms underlying CP and develop light as a novel analgesic treatment has its biological regulation principle for CP. This approach may provide an opportunity to drive the field towards future translational, clinical studies and support pain drug development.

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Effects of narcotics, including morphine, on visual evoked potential in rats

Cited by 10 publications

References 20 publications

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

Nogo Receptor Inhibition Enhances Functional Recovery following Lysolecithin-Induced Demyelination in Mouse Optic Chiasm

Non-invasive visual evoked potentials under sevoflurane versus ketamine-xylazine in rats

Looking for a Beam of Light to Heal Chronic Pain

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