Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain

Kaulaskar, Shyam; Bhutada, Pravinkumar; Rahigude, Anand; Jain, Dilpesh; Harle, U. N.

doi:10.3736/jcim20121223

Cited by 34 publications

(15 citation statements)

References 27 publications

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“…[73] Naringenin (8) (25 and 50 mg/ kg) showed ameliorating action against chronic constriction injury-induced neuropathic pain in sciatic nerve injury model through mechanisms of inhibition of NO pathway and ameliorating oxidative stress. [48] Biflavonoids is one of structurally unique classes of naturally occurring bioflavonoids which also have inhibitory effects on pain. Volkensiflavone (53), fukugetin (54), fukugeside (55).…”

Section: Apigenin Apigeninmentioning

confidence: 99%

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

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Section: Apigenin Apigeninmentioning

confidence: 99%

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao

Wang

Gui

et al. 2016

Chemistry & Biodiversity

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“…Estrogen deficiency causes an increase in nociceptive sensitivity (14). A high bone turnover, such as with postmenopausal osteoporosis, might augment skeletal pain via activation have demonstrated that pregabalin (10 ~ 40 mg/kg) improves the mechanical allodynia in the von Frey filament test caused by CCI (8,35). The difference between ours and previous reports could be because the weekly dose of pregabalin (10 mg/kg) in the present study may not have been enough to improve mechanical allodynia in our ovariectomized and CCI model.…”

Section: Discussionmentioning

confidence: 99%

Analgesic effects of minodronate in a rat chronic pain model

et al. 2018

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We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0.15 mg/kg/week), alendronate (0.15 mg/kg/week), pregabalin (10 mg/kg/week), or their vehicle was administered for 2 weeks starting on the 0th day of CCI. Behavioral evaluations, with von Frey testing and the hot plate test, were performed on days 0, 7 and 14. After 2 weeks, bilateral femurs and tibialis anterior muscles were harvested for bone mineral density and cross sectional area measurements, respectively. Two weeks treatment with minodronate significantly improved mechanical and thermal allodynia evaluated by the von Frey and hot plate tests in the CCI limb (P < 0.05). Minodronate and alendronate treatment for 2 weeks significantly increased total femoral bone mineral density in the CCI limb compared with pregabalin or vehicle treatment (P < 0.01). Cross sectional area of the CCI limb in the minodronate group was significantly larger than that of the alendronate group (P < 0.05) and pregabalin group (P < 0.05). Two-week treatment with minodronate, but not alendronate or pregabalin, improved mechanical and thermal allodynia caused by CCI in ovariectomized rats.

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“…In addition, JB have been reported to contain various bioactive compounds such as naringenin, apigenin and luteolin which have been reported to exhibit antidepressant, anti-neuroinflammation, anti-oxidant and cytoprotective effects [14] [15] [17] [38]. Apigenin and naringenin were also reported to exhibit analgesic activity in various acute and chronic animal models of pain [39] [40]. Also, naringenin and luteolin were shown to increased memory performance and to reverse scopolamine-induced amnesia in rodents through inhibition of AChE activity and oxidative stress-related processes [38] [41].…”

Section: Discussionmentioning

confidence: 99%

Jobelyn&reg;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

Umukoro¹,

Omorogbe²,

Aluko³

et al. 2015

JBBS

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The ability of an organism to adapt to aversive stressful situations or life challenging circumstances is very crucial to its state of health and survival. However, breakdown in adaptation due to persistent uncontrollable stress, leads to impairment of bodily functions and onset of a variety of pathological disorders especially memory decline. This study was designed to evaluate the effect of Jobelyn ® (JB), a potent antioxidant sorghum-based food supplement on unpredictable chronic mild stress (UCMS)-induced memory impairment in mice. Male Swiss mice were given JB (5-50 mg/kg, p.o) 30 min prior to exposure to UCMS for 14 consecutive days before testing for memory. Thereafter, the serum corticosterone level was estimated by using ELISA kits. The levels of malondialdehyde (MDA) and glutathione (GSH) as well as acetylcholinesterase activity were estimated in the brain homogenate using spectrophotometer. Histology of the brain tissues and estimation of the populations of viable neurons in the hippocampal region were done after staining with hematoxyline and eosin. Our results showed that JB reversed memory impairment and suppressed corticosterone concentrations induced by UCMS. Moreover, JB reduced oxidative stress in the brain of UCMS-mice as shown by decreased MDA levels and elevated GSH concentrations. It also decreased * Corresponding author. S. Umukoro et al. 587 brain acetylcholinesterase activity when compared with chronic stress group (p < 0.05). Furthermore, JB (5-10 mg/kg, p.o) offered significant protection against UCMS-induced degeneration and death of neuronal cells of the cornu ammonis 3 (CA3) of the hippocampal region of the brain indicating neuroprotection. Taken together, these findings suggest that JB attenuates memory deficits induced by UCMS in mice and may be useful therapeutically for stress-related cognitive dysfunctions. The reduction in the levels of serum corticosterone, antioxidation, neuroprotection and inhibition of cholinesterase enzyme might be contributing significantly to the positive effect of JB on memory in mice exposed to unpredictable chronic mild stress.

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Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain

Abstract: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.

Cited by 34 publications

References 27 publications

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

<b>Analgesic effects of minodronate in a rat chronic pain </b><b>model </b>

Jobelyn<sup>&reg;</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

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Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain

Abstract: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.

Cited by 34 publications

References 27 publications

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

<b>Analgesic effects of minodronate in a rat chronic pain </b><b>model </b>

Jobelyn&lt;sup&gt;&amp;reg;&lt;/sup&gt;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice

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Jobelyn<sup>®</sup>, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice