Effects of Nasturtium officinale Extract on Antioxidant and Biochemical Parameters in Hemodialysis Patients: A Randomized Double-Blind Clinical Trial

Abstract

Background. Increased oxidative stress play an important role in the risk of cardiovascular disease, mortality, and mortality patients undergoing dialysis. Nasturtium officinale (watercress) contains numerous phytochemical compounds that act as an antioxidant by preventing oxidative damage to biomolecules. Therefore, this research aimed to explore the effect of the ethanolic extract of Nasturtium officinale (EENO) on antioxidant and biochemical markers of hemodialysis patients. Methods. In this double-blind, placebo-controlled trial, 46 hemodialysis patients were randomly recruited to consume either 500 mg/day EENO (n = 23) or placebo capsule (n = 23) for 4 weeks, at Shahid Beheshti Hospital, Yasuj, Iran, in 2019. Biomarkers of oxidative stress including glutathione peroxidase (GPX), superoxide dismutase (SOD), malondialdehyde (MDA), total oxidant status (TOS), total antioxidant capacity (TAC), and total sulfhydryl protein (T-SH) and biochemical parameters such as BUN, Hb, WBC, PLT, Ca, Ph, K, ALB, TChol, TG, LDL, and HDL were evaluated on days 0 and 28. Results. The serum levels of MDA and BUN significantly decreased after taking EENO supplementation P < 0.001 ; however, SOD activity increased during the same period P < 0.001 . The serum levels of TAC remained constant in the intervention group, while it significantly declined in the placebo group P < 0.09 . The extract also prevented elevation in the serum levels of LDL and TG compared to the placebo group, although it was not statistically significant. Conclusions. The data indicated that the consumption of EENO improved some of the antioxidant parameters and minimizes the change in TG and LDL in hemodialysis patients. Therefore, due to the role of these factors in mortality and morbidity of dialysis patients, EENO can improve the condition of dialysis patients. However, more studies with longer intervention times and different doses of EENO are recommended.

The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients

“…During a four weeks' period, the patients in the intervention group took 500 mg hydroalcoholic extract of WC once a day and those in the control group received drug-like (capsule color, packing) containing 500 mg of white flour. Hydroalcoholic extract of WC dose was selected according to previous clinical and pharmacologic studies [ 3 , 21 ]. To confirm that the supplement was taken, the patient was asked to bring the capsule bottle to the next dialysis session.…”

“…RRT, which includes dialysis and kidney transplantation, is a treatment to extend the lifespan of ESRD patients [ 2 ]. Hemodialysis is the major therapy in the controlling of CKD, which can destroy vitamins, water-soluble peptides, and amino acids [ 3 ]. Dialysis is required when the glomerular filtration rate (GFR) in ESRD patients is reduced to 10 to 15 mL/min per 1.73 m 2 [ 4 , 5 ].…”

The ameliorative effect ofN‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats

“…[28] Measuring the MDA and TAC are important biochemical indices used for the investigation of harmful effects of some toxic materials. [29,30] PEN might induce intraneuronal oxidative stress through the promotion of LPO resulting in neuronal damage. [31] It also induces ROS overproduction manifested by decreased GSH, catalase, and glutathione peroxidase activities in neurons.…”

Green Synthesis of Silver Nanoparticles Using Nasturtium officinale L. Extract And Analysis of Their Antibacterial Activity Against Nosocomial Pathogens

“…It contains vitamins especially A, B, and C, phenolic compounds, folic acid, minerals, fibers, proteins, iron, and calcium, and a high level of glucosinolates which is the highest concentration compared to all other vegetable plants, along with high carotenoids concentration, for example, beta-carotene and lutein (20,21,22). Traditionally, the plant has numerous medical uses, such as anti-diabetes, antibacterial, stopping hemorrhages, chest pain, purifying blood, anemia, iron deficiency, throat expectorant, gallbladder, bronchitis, tumors and tuberculosis (23,24). Previous studies have displayed antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, and antihyperlipidemia features of the watercress in vitro and in vivo conditions (20,23,24).…”

“…Traditionally, the plant has numerous medical uses, such as anti-diabetes, antibacterial, stopping hemorrhages, chest pain, purifying blood, anemia, iron deficiency, throat expectorant, gallbladder, bronchitis, tumors and tuberculosis (23,24). Previous studies have displayed antioxidant, nephroprotective, anti-inflammatory, hepatoprotective, and antihyperlipidemia features of the watercress in vitro and in vivo conditions (20,23,24). In the present study, a simple and rapid approach was applied for the green synthesis of AgNPs using Nasturtium officinale L. leaf extract.…”