Effects of natural aging and gender on pro-inflammatory markers

Milan‐Mattos, Juliana Cristina; Aníbal, Fernanda de Freitas; Perseguini, Natália Maria; Minatel, Vinícius; Rehder-Santos, Patrícia; Castro, Cynthia Aparecida de; Vasilceac, Fernando Augusto; Mattiello, Stela Márcia; Faccioli, Lúcia Helena; Catai, Aparecida Maria

doi:10.1590/1414-431x20198392

Cited by 103 publications

(88 citation statements)

References 38 publications

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“…Overall, there are many similarities between the blood cytokine profile of aging and that observed in severely ill COVID-19 patients, including an elevated IL-6, which appears to play a key role in poor COVID-19 prognosis (Table 2). [63][64][65][66]…”

Section: Thymus and Covid-19 Diseasementioning

confidence: 99%

The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization

Kellogg

Equils²

2020

Human Vaccines & Immunotherapeutics

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The thymus is a largely neglected organ but plays a significant role in the regulation of adaptive immune responses. The effect of aging on the thymus and immune senescence is well established, and the resulting inflammaging is found to be implicated in the development of many chronic diseases including atherosclerosis, hypertension and type 2 diabetes. Both aging and diseases of inflammaging are associated with severe COVID-19 disease, and a dysfunctional thymus may be a predisposing factor. In addition, insults on the thymus during childhood may lead to abnormal thymic function and may explain severe COVID-19 disease among younger individuals; therefore, measurement of thymic function may assist COVID-19 care. Those with poor thymic function may be treated prophylactically with convalescent serum or recombinant antibodies, and they may respond better to high-dose or adjuvanted COVID-19 vaccines. Treatments inducing thymic regeneration may improve patients' overall health and may be incorporated in COVID-19 management.

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Section: Thymus and Covid-19 Diseasementioning

confidence: 99%

The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization

Kellogg

Equils²

2020

Human Vaccines & Immunotherapeutics

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“…The inflammatory cytokines are also related to insulin resistance in obesity [111,112]. IL-6 increases during life, being higher in the elderly compared to young people [113,114], since older people present a low-grade inflammatory state related to the development of the principal chronic degenerative diseases. Sex also influences the cytokine profile.…”

mentioning

confidence: 99%

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment

Cicco

Racanelli

et al. 2020

Mediators of Inflammation

153

148

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COVID-19 is a pandemic disease caused by the new coronavirus SARS-CoV-2 that mostly affects the respiratory system. The consequent inflammation is not able to clear viruses. The persistent excessive inflammatory response can build up a clinical picture that is very difficult to manage and potentially fatal. Modulating the immune response plays a key role in fighting the disease. One of the main defence systems is the activation of neutrophils that release neutrophil extracellular traps (NETs) under the stimulus of autophagy. Various molecules can induce NETosis and autophagy; some potent activators are damage-associated molecular patterns (DAMPs) and, in particular, the high-mobility group box 1 (HMGB1). This molecule is released by damaged lung cells and can induce a robust innate immunity response. The increase in HMGB1 and NETosis could lead to sustained inflammation due to SARS-CoV-2 infection. Therefore, blocking these molecules might be useful in COVID-19 treatment and should be further studied in the context of targeted therapy.

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“…On the other hand, studies of exon 5 c.520G>A variant in subjects of European, American and Asian ancestry, show that GG is the predominant genotype 26 , just as it occurred for the Mexican population. This distribution is difficult to explain; however we speculate that the phenomenon might be part of a gene drift, where one of the alleles has been fixed or extinguished, which in general causes a decrease in genetic variability in the human population.…”

Section: Group Evolution Time (Years)mentioning

confidence: 99%

Análisis del gen ORM1 en cáncer de mama: ¿es un factor de riesgo en población mexicana?

García-Ortiz¹,

Gutiérrez‐Salinas²,

Téllez-Araiza³

et al. 2020

GAMO

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Introduction: ORM1 gene located on the long arm of chromosome 9 encodes for alpha-1-acid glycoprotein (AGP1), the gene contains two single nucleotide variants located in exon 1 and exon 5, which are implicated in immunosuppressive activities of AGP1, affecting the progress and clinical course of diseases such as cancer. Due to the foregoing, the objective of this study was to determine the genotypic and allelic frequency of variants c.113G>A of exon 1 and c.520G>A of exon 5 of the ORM1 gene, to evaluate their association with breast cancer (BC). Materials and methods: A case-control study was conducted, 101 patients diagnosed with adenocarcinoma of mammary gland and 104 healthy women were included. Of each participant DNA was obtained for the genotyping of 2 variants of the gene ORM1 and assesses its clinical correlation. Results: The analysis of the genotypic and allelic frequencies of the variant c.520G>A of exon 5 showed that patients with BC had a higher frequency of the GG genotype compared to controls (99% vs. 89.42%; respectively). While the phenotype-genotype correlation of exon 1 showed that patients with BC and GG genotype had a higher age at the time of their last calving date, compared to genotype AA and AG patients (36.44 ± 0.83 vs. 32.35 ± 0.98 and 31.44 ± 0.83, respectively), both results was statistically significant (P < 0.05). Conclusions: The polymorphisms of the gene ORM1 and its protein could intervene in BC affecting the clinical course and progression of the disease.

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Effects of natural aging and gender on pro-inflammatory markers

Cited by 103 publications

References 38 publications

The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization

The role of the thymus in COVID-19 disease severity: implications for antibody treatment and immunization

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment

Análisis del gen ORM1 en cáncer de mama: ¿es un factor de riesgo en población mexicana?

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