Effects of natural products on functional constipation: analysis of active ingredient and mechanism

Zhou, Pengfei; Wang, Xiaopeng; Sun, Mingming; Yan, Shuai

doi:10.1007/s00210-023-02786-x

Cited by 5 publications

(2 citation statements)

References 159 publications

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“…Functional foods with laxative activity are deemed to exhibit exceptionally high safety and can serve as dietary supplements to improve intestinal function, ultimately preventing or treating constipation. [14][15][16][17] The model of constipation induced by loperamide hydrochloride is a widely recognized animal model of disease. 18 Loperamide hydrochloride is an opioid receptor agonist that inhibits intestinal peristalsis, delays intestinal transport function, and prolongs the retention of intestinal contents, inhibiting the secretion of intestinal epithelial cells and increasing the reabsorption of water by the mucous layer.…”

Section: Introductionmentioning

confidence: 99%

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Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Zhao,

Meng,

Sun

et al. 2024

Food Funct.

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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (Pinus densiflora) in Sprague-Dawley Rats with Loperamide-Induced Constipation

Song,

Seol,

Park

et al. 2024

Antioxidants

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Oxidative stress is the key cause of the etiopathogenesis of several diseases associated with constipation. This study examined whether the green pine cone can improve the symptoms of constipation based on the antioxidant activities. The changes in the key parameters for the antioxidant activity and laxative effects were examined in the loperamide (Lop)-induced constipation of Sprague-Dawley (SD) rats after being treated with the methanol extracts of green pine cone (MPC, unripe fruits of Pinus densiflora). MPC contained several bioactive compounds, including diterpenoid compounds such as dehydroabietic acid, taxodone, and ferruginol. In addition, it exhibited high scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals. These effects of MPC successfully reflected the improvement in nicotinamide adenine dinucleotide phosphate oxidase (NADP) H oxidase transcription, superoxide dismutase (SOD) levels, and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation levels in the mid colon of Lop+MPC-treated SD rats. Furthermore, significant improvements in the stool parameters, gastrointestinal (GI) transit, intestine length, and histopathological structure of the mid colon were detected in the Lop-induced constipation rats after MPC treatment. The other parameters, including the regulators for the adherens junction (AJ) and tight junction (TJ), and GI hormone secretion for laxative effects, were improved significantly in Lop+MPC-treated SD rats. These effects were also verified in Lop+MPC-treated primary rat intestine smooth muscle cells (pRISMCs) through analyses for antioxidant defense mechanisms. Overall, the finding of this study offers novel scientific evidence that MPC could be considered as a significant laxative for chronic constipation based on its antioxidant activity.

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Senegalin-2: A Novel Hexadecapeptide from Kassina senegalensis with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a Bradykinin Antagonist

Lu,

Zhu,

et al. 2024

Biomolecules

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The amphibian skin secretions are excellent sources of bioactive peptides, some of which and their derivatives exhibit multiple properties, including antibacterial and antagonism against bradykinin. A novel peptide Senegalin-2 was isolated from the skin secretions of Kassina senegalensis frog. Senegalin-2 relaxed rat bladder smooth muscle (EC50 17.94 nM) and ileum smooth muscle (EC50 135 nM), inhibited S. aureus and MRSA at 2 μM, and exhibited low hemolytic activity with no cytotoxicity. To design effective bradykinin antagonists, Senegalin-2 was conjugated with bradykinin to synthesize Senegalin-2BK. This modification retained potent activity against Gram-positive bacteria. Compared to Senegalin-2, Senegalin-2BK significantly reduced hemolysis and exhibited a more than threefold increase in the selectivity index. Furthermore, Senegalin-2BK contracted the bladder (EC50 2.83 μM) and ileum (EC50 56.64 nM)’s smooth muscle. The pretreatment with 10−7 M Senegalin-2BK reduced the 10−6 M bradykinin contraction on the bladder by over 70%. In conclusion, Senegalin-2 has dual functionalities as an antibacterial agent and muscle relaxant, positioning it as a potential therapeutic candidate for managing overactive bladder. As a synthetically derived bradykinin antagonist and myotropic peptide with antibacterial properties, Senegalin-2BK shows promise in effective therapies for relieving pain, inflammation, and addressing muscular disorders such as urinary retention, constipation, and infections.

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Effects of natural products on functional constipation: analysis of active ingredient and mechanism

Cited by 5 publications

References 159 publications

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (Pinus densiflora) in Sprague-Dawley Rats with Loperamide-Induced Constipation

Senegalin-2: A Novel Hexadecapeptide from Kassina senegalensis with Antibacterial and Muscle Relaxant Activities, and Its Derivative Senegalin-2BK as a Bradykinin Antagonist

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