Effects of natural <scp><i>S</i></scp>‐equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status

Usui, Takeshi; Tochiya, Mayu; Sasaki, Yukiyoshi; Muranaka, Kazuya; Yamakage, Hajime; Himeno, Akihiro; Shimatsu, Akira; Inaguma, Asami; Ueno, Tomomi; Uchiyama, Shigeto; Satoh‐Asahara, Noriko

doi:10.1111/j.1365-2265.2012.04400.x

Cited by 128 publications

(116 citation statements)

References 33 publications

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“…Isoflavones are one of the phytoestrogens that are possible preventive factors in several hormone-dependent cancers such as prostate cancer and breast cancer (Zhu et al, 2011;Khan et al, 2012 ), cardiovascular disease (Wong et al, 2012;Usui et al, 2013), menopausal symptoms (Aso et al, 2012;Jenks et al, 2012), and osteoporosis (Scheiber et al, 2001;Tousen et al, 2011). Especially, genistein and daidzein, which are aglycones of isoflavones, were found to have potential roles in the prevention of prostate cancer (Akaza et al, 2004;Nagata et al, 2007;Gardner et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Sugiyama¹,

Nagata²,

Fukuta³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Isoflavones, which are included in soybeans, have been suggested to protect against prostate cancer. Equol, one of isoflavones, is an intestinally derived bacterial metabolite of daidzein. A newly identified equol-producing bacterium, Slackia sp. strain NATTS, with a high equol-producing activity was isolated from human feces in Japanese adults. Counts of Slackia sp. strain NATTS in intestinal flora have not been assessed with regard to prostate cancer risk. In this study, we investigated the association of serum isoflavones and counts of Slackia sp. strain NATTS with prostate cancer risk in a case-control study. Materials and Methods: Concentrations of isoflavones and counts of Slackia sp. strain NATTS in feces were measured from 44 patients with prostate cancer and 28 hospital controls. The risk of prostate cancer was evaluated in terms of odds ratios (ORs) and 95% confidence intervals (CIs) by the logistic regression analysis. Results: The detection proportions of Slackia sp. strain NATTS in cases and controls were 34.1% and 25.0%, respectively. Counts of Slackia sp. strain NATTS were significantly correlated with serum concentrations of equol both in cases and controls (Spearman correlation coefficients, r s =0.639 and r s =0.572, p<0.01, respectively). Serum concentrations of genistein, daidzein, glycitein, and equol were not significantly associated with risk of prostate cancer. Conclusions: This study found that counts of Slackia sp. strain NATTS correlated with serum concentrations of equol both in prostate cancer cases and controls, but serum isoflavone concentrations were not associated with risk of prostate cancer in our patients.

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Section: Introductionmentioning

confidence: 99%

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Sugiyama¹,

Nagata²,

Fukuta³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…To determine the equol production status, participants underwent a soy challenge in accordance with the procedure described previously 25. Participants were instructed to eat soy food containing approximately 50 mg isoflavones twice a day, and then first morning urine samples were collected the next morning.…”

Section: Methodsmentioning

confidence: 99%

Premenstrual symptoms interference and equol production status in Japanese collegiate athletes: A cross‐sectional study

Takeda

Ueno

Uchiyama

et al. 2017

J of Obstet and Gynaecol

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AimConsumption of soy isoflavones reduces the risk of estrogen‐related diseases, such as menopausal symptoms, osteoporosis, and cardiovascular disease. Equol is metabolized from the isoflavone daidzein by intestinal bacteria and has higher bioavailability than other isoflavones. Equol producers are believed to benefit from soybean consumption to a greater extent than non‐producers. Recently, we showed that equol non‐producers were at significant risk of premenstrual syndrome (PMS). Previously, we reported that PMS is a common menstrual problem in female athletes, and almost half of the studied athletes felt a negative effect of premenstrual symptoms on their athletic performance. This study was conducted to evaluate the relation between PMS and equol production status in Japanese collegiate athletes.MethodsThis was a cross‐sectional, observational study that included 88 Japanese female collegiate athletes. Equol production status was determined using urine samples collected after a soy challenge test. The subjects also completed a questionnaire about their premenstrual symptoms and their competitive career.ResultsThe prevalence of equol producers was 29.5% in Japanese collegiate athletes. The athletic performance of 54.5% of athletes was found to suffer in competition or in practice due to premenstrual symptoms. In multivariate analysis, equol non‐producers (odds ratio, 3.34; 95% confidence interval, 1.03–12.20) and restriction of bodyweight (odds ratio, 4.94; 95% confidence interval, 1.47–20.00) were shown to be significant risk factors for poor athletic performance.ConclusionThis study showed a relation between athletic performance and equol production status in Japanese collegiate athletes.

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“…Since that time this hypothesis has been hotly debated. Equol does appear to offer health benefits over its precursor daidzein [82,83] in possibly several different areas but especially in the alleviation of hot flashes [84,85,86]. However, it also may be that in some cases it is the equol-producing phenotype (i.e., the ability to produce equol) rather than equol itself, that is responsible for the more beneficial response to isoflavone ingestion [87].…”

Section: Isoflavonesmentioning

confidence: 99%

Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

2016

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Soyfoods have long been recognized as sources of high-quality protein and healthful fat, but over the past 25 years these foods have been rigorously investigated for their role in chronic disease prevention and treatment. There is evidence, for example, that they reduce risk of coronary heart disease and breast and prostate cancer. In addition, soy alleviates hot flashes and may favorably affect renal function, alleviate depressive symptoms and improve skin health. Much of the focus on soyfoods is because they are uniquely-rich sources of isoflavones. Isoflavones are classified as both phytoestrogens and selective estrogen receptor modulators. Despite the many proposed benefits, the presence of isoflavones has led to concerns that soy may exert untoward effects in some individuals. However, these concerns are based primarily on animal studies, whereas the human research supports the safety and benefits of soyfoods. In support of safety is the recent conclusion of the European Food Safety Authority that isoflavones do not adversely affect the breast, thyroid or uterus of postmenopausal women. This review covers each of the major research areas involving soy focusing primarily on the clinical and epidemiologic research. Background information on Asian soy intake, isoflavones, and nutrient content is also provided.

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Effects of natural S‐equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status

Cited by 128 publications

References 33 publications

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Counts of Slackia sp. strain NATTS in Intestinal Flora are Correlated to Serum Concentrations of Equol both in Prostate Cancer Cases and Controls in Japanese Men

Premenstrual symptoms interference and equol production status in Japanese collegiate athletes: A cross‐sectional study

Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

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