Effects of naturally occurring flavonoids on ferroportin expression in the spleen in iron deficiency anemia in vivo

Mazhar, Maryam; Faizi, Shaheen; Gul, Anum; Kabir, Nurul; Simjee, Shabana Usman

doi:10.1039/c7ra02138k

Cited by 16 publications

(15 citation statements)

References 33 publications

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“…In addition to demonstrating the pro-apoptotic action exerted by quercetin, quercetagetin and patuletin inside tumor cells, we were also able to determine that these compounds show a selective effect on non-tumor cells, since when normal lymphocytes were treated with the doses applied to the cancer cell lines, the necrotic effect measured was not statistically-significant. Finally, and contrary to their effect on tumor cells, the compounds evaluated herein exhibited a non-antiproliferative effect inside non-tumor cells, relevant data that could be used in other investigations [ 38 ] with flavonoids [ 39 ]. All these results allow us to propose these flavonoids and modifications in substitution patterns in C6 as options that have selective activity against cancer cells but do not damage normal cells, indicating that they may have future utilization in cancer treatment or other biological activities.…”

Section: Discussionmentioning

confidence: 88%

Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

et al. 2018

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Quercetagetin and patuletin were extracted by the same method from two different Tagetes species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC50 and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.

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Section: Discussionmentioning

confidence: 88%

Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

et al. 2018

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“…Lesjak et al [66] reported that quercetin treatment can influence intestinal iron uptake by inhibition of iron absorption and by decreasing the expression of duodenal DMT1 and FPN. However, Mazhar et al [67] showed that various polyphenols regulate ferroportin expression and iron homeostasis differently, which might result from differences in their structures. Furthermore, it is required to elucidate the precise mechanism of action of herbal bioactive compounds on mineral absorption in order to improve the efficient utilization of trace elements from various sources (organic/inorganic) in ruminants with a gastrointestinal infection.…”

Section: Discussionmentioning

confidence: 99%

Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?

et al. 2020

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This study was conducted to evaluate the effect of feed supplementation with a medicinal herbs mixture (Hmix) and organic zinc (Zn), alone or in combination, on the antioxidant responses and mineral status of lambs infected with the gastrointestinal nematode parasite Haemonchus contortus. A total of 24 experimentally infected lambs were randomly allocated to 1 of 4 dietary treatments (n = 6). The diets included an unsupplemented control diet (CON) and the CON further supplemented with Hmix, Zn, or both Hmix + Zn. Antioxidant enzymes activities, lipid peroxidation, total antioxidant capacity (TAC) and microelement (Zn, Cu, Fe, Mn) concentrations were analyzed in serum, liver, kidney, and intestinal mucosa. Zinc treatment elevated the superoxide dismutase activities in the duodenal mucosa and ileal TAC. Intake of Hmix resulted in higher kidney and ileal catalase activity and also influenced the TAC of the liver and intestinal mucosa. The inclusion of Hmix or Zn alone into the diet increased glutathione peroxidase activity in the blood, liver and duodenal mucosa. Tissue mineral uptake was not affected by herbal supplementation. Organic Zn intake increased the serum and liver Zn levels and influenced the Cu concentration in duodenal mucosa. Dietary supplementation with Hmix and/or Zn might promote the antioxidant status of lambs infected with Haemonchus spp.

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“…However, quercetin can also repress the expression of ferroportin and hephaestin, and subsequently inhibits basolateral iron absorption [23,24]. Another possible mechanism is that quercetin may be able to chelate iron in the enterocytes and the quercetin iron complex being retained in the cytosol [25]. Therefore, the reduction in ferritin level may be as the result of functional cellular iron deficiency [26].…”

Section: Discussionmentioning

confidence: 99%

Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study

et al. 2020

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Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease which has become a public health concern. Since oxidative stress plays a crucial role in the pathogenesis of NAFLD, subsequent hematological disorders are expected. Therefore, antioxidant compounds such as quercetin could ameliorate the related side-effect of oxidative stress. The aim of the current study was to assess the effect of quercetin on hematological parameters in NAFLD patients. A randomized, double-blind, placebo-controlled trial was conducted as a pilot study. In this study 90 patients with NAFLD were supplemented with either a quercetin or a placebo capsule twice daily (500 mg) for 12 weeks. Blood sample was obtained for laboratory parameters at baseline and the end of week 12. End of trial values for red blood cell (RBC; p = 0.002), mean corpuscular hemoglobin concentration (p = 0.029), and mean platelet volume (p = 0.017), significantly increased and the levels of mean corpuscular volume (MCV; p = 0.023), RBC distribution width-coefficient of variation (p = 0.005), platelet distribution width (p = 0.015), and ferritin (p = 0.002) significantly decreased compared to the baseline in group receiving quercetin. Between group analysis revealed that RBC significantly increased (p = 0.025) but, mean corpuscular volume (p = 0.004), mean corpuscular hemoglobin (MCH; p = 0.002), and ferritin (p = 0.013) significantly decreased compared to placebo group. In this work quercetin showed significant effect on RBC, ferritin, MCV, and MCH in intervention group.

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Effects of naturally occurring flavonoids on ferroportin expression in the spleen in iron deficiency anemia in vivo

Abstract: Polyphenols with iron supplement exert variable effects on key players of iron homeostasis in iron deficiency anemia.

Cited by 16 publications

References 33 publications

Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines

Does Herbal and/or Zinc Dietary Supplementation Improve the Antioxidant and Mineral Status of Lambs with Parasite Infection?

Effects of Quercetin Supplementation on Hematological Parameters in Non-Alcoholic Fatty Liver Disease: a Randomized, Double-Blind, Placebo-Controlled Pilot Study

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