Effects of Nd doping on structural, optical, morphological and surface-chemical state analysis of ZnO nanoparticles for antimicrobial and anticancer activities

Indumathi, T.; Theivarasu, C.; Pradeep, I.; Rani, Manju; Magesh, Ganesan; Rahale, C. Sharmila; Kumar, Е. Ranjith

doi:10.1016/j.surfin.2021.101000

Cited by 27 publications

(6 citation statements)

References 39 publications

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“…Peaks at 1036 and 1378 cm −1 are due to bending vibration of C-O and phenolic O-H groups, respectively. The peak at 513 cm −1 shows the Zn–O stretching vibrations [ 70 ]. The negligible peak at 2924 cm −1 corresponds to alkanes C-H.…”

Section: Resultsmentioning

confidence: 99%

Phytogenically Synthesized Zinc Oxide Nanoparticles (ZnO-NPs) Potentially Inhibit the Bacterial Pathogens: In Vitro Studies

Khan

Lone

Shahid

et al. 2023

Toxics

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The usefulness of nanoparticles (NPs) in biological applications, such as nanomedicine, is becoming more widely acknowledged. Zinc oxide nanoparticles (ZnO-NPs) are a type of metal oxide nanoparticle with an extensive use in biomedicine. Here, ZnO-NPs were synthesized using Cassia siamea (L.) leaf extract and characterized using state-of-the-art techniques; UV–vis spectroscopy, XRD, FTIR, and SEM. At sub-minimum inhibitory concentration (MIC) levels, the ability of ZnO@Cs-NPs to suppress quorum-mediated virulence factors and biofilm formation against clinical MDR isolates (Pseudomonas aeruginosa PAO1 and Chromobacterium violaceum MCC-2290) was tested. The ½MIC of ZnO@Cs-NPs reduced violacein production by C. violaceum. Furthermore, ZnO@Cs-NPs sub-MIC significantly inhibited virulence factors such aspyoverdin, pyocyanin, elastase, exoprotease, rhamnolipid, and the swimming motility of P. aeruginosa PAO1 by 76.9, 49.0, 71.1, 53.3, 89.5, and 60%, respectively. Moreover, ZnO@Cs-NPs also showed wide anti-biofilm efficacy, inhibiting a maximum of 67 and 56% biofilms in P. aeruginosa and C. violaceum, respectively. In addition, ZnO@Cs-NPs suppressed extra polymeric substances (EPS) produced by isolates. Additionally, under confocal microscopy, propidium iodide-stained cells of P. aeruginosa and C. violaceum show ZnO@Cs-NP-induced impairment in membrane permeability, revealing strong anti-bacterial efficacy. This research demonstrates that newly synthesized ZnO@Cs-NPs demonstrate a strong efficacy against clinical isolates. In a nutshell, ZnO@Cs-NPs can be used as an alternative therapeutic agent for managing pathogenic infections.

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Section: Resultsmentioning

confidence: 99%

Phytogenically Synthesized Zinc Oxide Nanoparticles (ZnO-NPs) Potentially Inhibit the Bacterial Pathogens: In Vitro Studies

Khan

Lone

Shahid

et al. 2023

Toxics

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“…The O–H stretching vibrations of the water molecules adsorbed on the ZnO surface are responsible for a broad absorption band that is present in all samples of about 3400 cm −1 . [ 39 ] The absorption peak at 2331 cm −1 corresponds to C=O stretching vibrations. [ 40 ] Due to the carbonate phase's presence in the produced NPs, the peak assigned around 1400 cm −1 corresponds to the symmetric stretching vibration of C=O.…”

Section: Resultsmentioning

confidence: 99%

Tailoring Ultraviolet Band Absorption and Emission Features of ZnO Nanoparticles Through the Crystallite Size and Lattice Strain Modulation: Role of Yttrium Ions

Kumari

Nirmala

Chidhambaram

et al. 2022

Physica Status Solidi (b)

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Due to their unique characteristics, semiconductors have undergone a blooming revolution in recent decades. Among the multifarious semiconductor nanomaterials such as TiO 2 , SnO 2 , ZnO, ZrO 2 , CeO 2 , NiO, Fe 2 O 3 , In 2 O 3 , and ZnO paved a new way for the research community to explore the nanotechnology field. ZnO is a multipurpose II-VI group n-type semiconductor compound with remarkable chemical and thermal stabilities, a wide direct bandgap of 3.3 eV, a high exciton binding energy of 60 meV, and great level transparency at ambient temperature. [1][2][3] Further, ZnO possesses high thermal and chemical stability. [4] The aforementioned characteristics show that ZnO is a highly alluring material with a wide range of applications, including solar cells, lightemitting diodes, piezoelectric devices, laser diodes, thin-film resistors, sensors, paints, photocatalysts, and antibacterial agents. [5][6][7][8][9][10][11] ZnO is an amphoteric oxide and naturally crystallizes in a hexagonal wurtzite structure with space group P6 3mc . It is highly active under ultraviolet light irradiation that limits its usage in the region. [3] Metal ion-doped semiconductors tune the bandgap, structural modification, and alter the luminescent properties of ZnO. Recently, the research community has piled up their core interest in doping ZnO with rare earth elements in particular Y, Sc, Eu, Tb, etc. because of their localized, partially occupying 4f electrons that emphasize the transmittance performance in the visible region and minimizes the natal point defect densities in ZnO. [12,13] It is observed that the Sc-doped ZnO increases visible light wavelength transmittance, Eu-doped ZnO serves as an ideal photocatalytic agent, and Y-doped ZnO enhances the luminescent properties of ZnO. [12,14,15] Among the various RE elements cited above, Y is more significant as the atomic radius is greater than that of Zn, and several oxygen voids emerge due to the phase segregation of Y 3þ ions. [1] The current research work involves the synthesis of REM ion Y-doped ZnO nanoparticles (NPs) with various concentrations of yttrium by a simple co-precipitation method. Several analytical techniques were deployed to investigate the modification of structural, optical, surface

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“…Nanocerium has been reported to possess antibacterial properties mediated via oxidative stress [ 28 ]. In another study, Ce-doped ZnO nanoparticles showed inhibitory actions against Staphylococcus aureus , Streptococcus pneumonia , Klebsiella pneumoniae , Shigella dysenteriae , Escherichia coli , Pseudomonas aeruginosa , and Proteus vulgaris bacterial strains [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Considering their economic value, rare earth (RE) elements such as La, Ce Eu, Gd, etc., are another appropriate choice for ZnO doping as they add interesting features to the material. Indeed, RE-doped ZnO NPs are already used to inhibit microbial growth, providing a significant reinforcement in anticancer and antibacterial efficacy [ 36 , 37 , 38 , 39 ]. It has also been confirmed that RE-doped ZnO NPs constitute very potent biomarkers for early cancer diagnosis [ 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles

Hannachi

Khan

Slimani

et al. 2022

Biology

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Zinc oxide nanoparticles (ZnO NPs) are a promising platform for their use in biomedical research, especially given their anticancer and antimicrobial activities. This work presents the synthesis of ZnO NPs doped with different amounts of rare-earth ions of ytterbium (Yb) and cerium (Ce) and the assessment of their anticancer and antimicrobial activities. The structural investigations indicated a hexagonal wurtzite structure for all prepared NPs. The particle size was reduced by raising the amount of Ce and Yb in ZnO. The anticancer capabilities of the samples were examined by the cell viability MTT assay. Post 48-h treatment showed a reduction in the cancer cell viability, which was x = 0.00 (68%), x = 0.01 (58.70%), x = 0.03 (80.94%) and x = 0.05 (64.91%), respectively. We found that samples doped with x = 0.01 and x = 0.05 of Yb and Ce showed a better inhibitory effect on HCT-116 cancer cells than unadded ZnO (x = 0.00). The IC50 for HCT-116 cells of Ce and Yb co-doped ZnO nanoparticles was calculated and the IC50 values were x = 0.01 (3.50 µg/mL), x = 0.05 (8.25 µg/mL), x = 0.00 (11.75 µg/mL), and x = 0.03 (21.50 µg/mL). The treatment-doped ZnO NPs caused apoptotic cell death in the HCT-116 cells. The nanoparticles showed inhibitory action on both C. albicans and E. coli. It can be concluded that doping ZnO NPs with Yb and Ce improves their apoptotic effects on cancer and microbial cells.

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Effects of Nd doping on structural, optical, morphological and surface-chemical state analysis of ZnO nanoparticles for antimicrobial and anticancer activities

Cited by 27 publications

References 39 publications

Phytogenically Synthesized Zinc Oxide Nanoparticles (ZnO-NPs) Potentially Inhibit the Bacterial Pathogens: In Vitro Studies

Phytogenically Synthesized Zinc Oxide Nanoparticles (ZnO-NPs) Potentially Inhibit the Bacterial Pathogens: In Vitro Studies

Tailoring Ultraviolet Band Absorption and Emission Features of ZnO Nanoparticles Through the Crystallite Size and Lattice Strain Modulation: Role of Yttrium Ions

In Vitro Antimicrobial and Anticancer Peculiarities of Ytterbium and Cerium Co-Doped Zinc Oxide Nanoparticles

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