Effects of Nd: YAG laser photoradiation on intra‐abdominal tissues: A histological study of tissue damage versus power density applied

Brackett, Kim A.; Sankar, M. Y.; Joffe, Stephen N.

doi:10.1002/lsm.1900060206

Cited by 45 publications

(11 citation statements)

References 12 publications

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“…At energies of 2 1,200 J/cm, heat coagula- in which a histiocytic reaction with multinucleated giant cells was present (Fig. 5b) tion was predominant in tumor tissue showing characteristic changes as described previously [ 10,11,38,56]; histological and cytological structures had remained intact and tumor cells appeared with acidophilic cytoplasm and pyknotic elongated nuclei. At laser energies up to 1,200 J/cm, heat coagulation could be observed only at the site of diffuser insertion.…”

Section: Histopathologymentioning

confidence: 73%

Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liver metastases

Hillegersberg¹,

Staveren

Kort³

et al. 1994

Lasers Surg. Med.

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Interstitial laser coagulation as a means of destructing hepatic metastases was investigated. Colon carcinoma CC531 was implanted in the liver of 42 Wag/Rij rats; 20 days later, tumors (5.5 +/- 0.2 mm) were exposed to 1,064 nm Nd:YAG laser light at 4 W/cm and either 600, 1,200, 2,400, 3,400, or 4,800 J/cm from a 0.5 cm Helioseal coated cylindrical diffuser. Temperature and fluence rate were measured at the tumor boundary. Lesions were studied on day 2 and 36 posttreatment by light microscopy. Tumor proliferative activity was assessed by bromodeoxyuridine incorporation. Liver damage and function were determined by serum liver enzymes and antipyrine clearance. Fluence rate increased during laser treatment up to 170%; mean temperature increased logarithmically up to 69.7 degrees C. Short-term light microscopy showed coagulation necrosis of 7-11 mm without charring. Lesion size and liver enzymes increased logarithmically with laser energy applied. No deterioration in liver function was found. At 4,800 J/cm complete tumor remission occurred in three of four animals. This study shows the ability of interstitial laser coagulation to produce selective destruction of colonic tumor within the liver.

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Section: Histopathologymentioning

confidence: 73%

Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liver metastases

Hillegersberg¹,

Staveren

Kort³

et al. 1994

Lasers Surg. Med.

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“…Review of literature even indicates the use of this laser in arthroscopic surgery of temporomandibular joint [21]. It is also associated with less scarring, as there is decreased production of fibroblasts with Nd: YAG laser [22]. A study in literature reports the reduced in vivo local recurrence with contact Nd: YAG laser scalpel [23].…”

Section: Discussionmentioning

confidence: 96%

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Tewari

Rai

Singh

et al. 2007

Journal of Surgical Oncology

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“…Review of literature even indicates the use of this laser in arthroscopic surgery of temporomandibular joint [21]. It is also associated with less scarring, as there is decreased production of fi broblasts with Nd:YAG laser [22]. A study in literature reports the reduced in vivo local recurrence with contact Nd:YAG laser scalpel [23].…”

Section: Discussionmentioning

confidence: 99%

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

Singh

Tiwari

Shukla

et al. 2009

Indian J Otolaryngol Head Neck Surg

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Objective To asses the effi cacy of Nd:YAG laser for stage I squamous cell carcinoma of the lip. To the authors' knowledge this is the fi rst reported study on this subject. Study designRetrospective study design involving treatment of 46 patients of either sex of stage I squamous cell carcinoma of lip over a 10-year period in a single tertiary care university teaching hospital with Nd:YAG laser.Methods Nd:YAG laser ablation of lesions in lip was carried out in all the patients on an OPD basis with prior consent. A regular follow-up was maintained for a period of 5 years. A negative biopsy at the end of one month and one year was considered a treated case. The tabulated data was analysed statistically by "Kaplan Meier" method and "Log Rank" test. Also cosmetic and functional results were assessed by any sign of fl ow away after fi lling the oral cavity with water and postoperative integrity of facial nerve in accordance with "House Brackmann" classifi cation.Results In this series of 46 patients, 35 patients were disease free at the end of 3 years and this number further declined to 29 at the end of 5 years with 4 deaths and 2 more patients lost to follow-up. The statistical evaluation by Kaplan Meier method gives us an overall 5-year survival rate of 88.14% with a mean survival of 58 months. Further 8 patients required repeat laserization either for residual or recurrence of lesion. Also 2 patients had a lymph node metastasis during the follow-up period. Thus, by applying Kaplan Meier method recurrence-free survival (RFS) and diseasefree survival was found to be 85.1% (mean: 55 months) and 73.34% (mean: 57 months respectively. Interestingly on applying Log Rank test it was observed that the site of the lip involvement, i.e. whether upper or lower had no infl uence on disease-free survival. It was also observed that history of tobacco intake did not infl uence the disease free survival either (Log Rank Test). Moreover the cosmetic results were excellent and with no signifi cant complication observed. ConclusionThe results reported here support the use of Nd:YAG laser for treatment of Stage I squamous cell carcinoma of lip in accordance with principles of minimal invasive and morbid surgery.

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Effects of Nd: YAG laser photoradiation on intra‐abdominal tissues: A histological study of tissue damage versus power density applied

Cited by 45 publications

References 12 publications

Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liver metastases

Interstitial Nd:YAG laser coagulation with a cylindrical diffusing fiber tip in experimental liver metastases

Long‐term follow‐up results of Nd: YAG laser treatment of premalignant and malignant (Stage I) squamous cell carcinoma of the oral cavity

Nd:YAG laser therapy of carcinoma lip (stage I squamous cell carcinoma): a retrospective evaluation

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