Effects of Nebulized Albuterol in Transient Tachypnea of the Newborn A Clinical Trial

Mussavi, Mirhadi; Asadollahi, Khairollah; Mirnia, Kayvan; Sadeghvand, Shahram

doi:10.5812/ijp.8211

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Regarding the adverse effects of epinephrine and salbutamol inhalations such as tachycardia, hypokalemia, and hypoglycemia, there were no statistically signi cant differences between all the studied groups Table (3). Similarly, all the previous trials using either epinephrine or salbutamol inhalation did not demonstrate any adverse effects from those interventions for both single and multiple doses 2,10,19,20,21,23,25,26,27,28 . It depicts the safety and tolerability of these interventions as reported by the current study and the previous studies.…”

Section: Adverse Effectsmentioning

confidence: 73%

Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

Noaman

Soliman

El-Sallab

et al. 2023

Preprint

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Objective: To evaluate the efficacy and the safety of inhaled salbutamol and epinephrine in the treatment of TTN. Design: Double-blinded randomized control pilot study was carried out on 135 near and full-term infants with TTN in the NICU of Mansoura University children's hospital. They were randomly assigned to receive either a single dose of epinephrine, salbutamol, or placebo inhalation. The primary outcome was the level of TTN Downe’s score and the required respiratory support. PaO2 and PaCO2, duration of oxygen therapy, hospital stay, and the adverse effects were considered secondary outcomes. registered at www.clinicaltrials.gov (NCT05006235). Results: Downe’s score, CPAP requirement, and PaCO2 were significantly less in the salbutamol and epinephrine groups, in addition to a shorter duration of oxygen support and hospital stay with tolerable adverse effects. Conclusion: Epinephrine or salbutamol inhalation in treatment of TTN is safe, well tolerated, and effective in reduction of the severity of respiratory distress.

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Section: Adverse Effectsmentioning

confidence: 73%

Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

Noaman

Soliman

El-Sallab

et al. 2023

Preprint

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“…The need for positive pressure ventilation was decreased in those babies who were given Salbutamol inhalation. 17 Similarly, another study conducted by Armangil et al, on the possible effects of Salbutmol inhalation on 54 infants with TTN revealed reduced need for oxygen support and mechanical ventilation after the initial 30 minutes of Salbutamol inhalation. 20 A Korean study evaluated the effects of inhaled Salbutamol in TTN demonstrated reduction of tachypnea in the infants receiving Salbutamol intervention and also the duration of supplemental oxygen requirement.…”

Section: Discussionmentioning

confidence: 86%

“…13,14,15 The incidence of TTN in Pakistan was found to be 14.1%. 16,17 At birth, the release of catecholamines, steroids and vasopressin affect the balance of fluid in the alveoli from fluid secretion to fluid absorption, thereby facilitating the adaptation to ex-utero enviornment. 18,19 NICUs in developing countries like Pakistan have limited resources and are overburdened with neonates diagnosed with TTN.…”

Section: Discussionmentioning

confidence: 99%

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Khushdil

Ahmed

et al. 2022

PAFMJ

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Objective: To assess and compare the effect of Salbutamol and Furosemide therapy in the management of transient tachypnea of newborn. Study Design: Randomized controlled trial (Registered with Clinical Trials.gov: NCT03208894). Place and Duration of Study: Neonatal Intensive Care Unit of Pakistan Emirates Military Hospital Rawalpindi from Oct 2019 to May 2020. Methodology: A total of 100 newborns were included in the study. They were divided into 4 groups. Group-A received nebulized 0.1ml Salbutamol. Group-B was given single intravenous dose of injection Furosemide at the dose of 2mg per kg. Group-C received both IV Furosemide and nebulized Salbutamol. Control group-D received only supportive care. Results: There were 48 male babies and 52 female babies. The average gestational age was 38.8 ± 6.2 weeks and the average birth weight was 2558 ± 620 grams. Administration of both Salbutamol and IV Furosemide together (group-C) showed significant reduction in the mean duration of oxygen dependency compared to control-group (13.40 ± 3.342 vs 83.64 ± 68.546 hours respectively (p<0.001), as well as the need for mechanical ventilation. The mean duration of oxygen dependency in other two groups (A and B) were also reduced compared to control group, but the results were not statistically significant. Conclusion: Salbutamol and Furosemide when given together tend to reduce the duration of oxygen dependency and need for invasive mechanical ventilation in babies with transient tachypnea of newborn.

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“…16 On the other hand, Mussavi et al While conducting a study on TTN, identified equal gender distribution (male 51.7%) with an average birth weight of 2.70kg and mean gestational age of 36.9 weeks. 17 On the contrary, Kaur et al in India found a male predominance as 65% of their studied newborns were male. 18 In our patients, TTN scores before and 4 hours after treatment with Salbutamol were 8.30±1.37 and 2.67±0.76, respectively, with an observed mean change of 5.63±1.22.…”

Section: Discussionmentioning

confidence: 88%

“…In a randomized controlled trial conducted in Iran, Mussavi et al also managed 60 neonates with TTN on CPAP and improvement was witnessed with albuterol nebulization (0.15 mg/kg) as respiratory distress score improved from 5.6 to 1.7, in contrast to 5.6 to 3.9 in the placebo group (saline nebulization). 17 However, in India, Basiri et al while managing 100 newborns with TTN on nasal prong oxygen at the gestational age of 35-41 weeks, failed to identify any improvement in TTN Score before and 4 hours after Salbutamol (0.15 mg/kg) nebulization as the reported scores were 5.7 and 5.4 respectively. 18 In our study group, RR (respiratory rate) was 69.43±4.25 per minute before Salbutamol administration, with the exhibited change of 9.80±2.05 post salbutamol.…”

Section: Discussionmentioning

confidence: 99%

Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

Ahmed

Tahir²,

Subhani³

et al. 2022

PAFMJ

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Objective: To compare the outcome of Salbutamol nebulization with normal saline (placebo) in transient tachypnea of the newborn. Study Design: Comparative prospective study. Place and Duration of Study: Department of Neonatal Medicine, Military Hospital Rawalpindi, from Jan 2017 to Mar 2018. Methodology: Sixty term neonates with respiratory rate >60 breaths/min and transient tachypnea of newborn score of ≥4 were enrolled. They were randomly allocated to two equal groups. Group-1 received Salbutamol nebulization (0.15 mg/kg) while Group-2 received normal Saline (placebo) nebulization. Results: The mean gestational age was 38.31±1.28 weeks, while the average birth weight was 2.97±0.27 kg. The mean change in transient tachypnea of newborn score with Salbutamol nebulization was 5.63±1.22, while 0.63±1.54 with normal Saline nebulization. Likewise, the mean change in respiratory rate with Salbutamol was 9.80±2.05, while -3.73±2.57 with normal saline. Conclusion: This study demonstrated nebulized Salbutamol as an effective tool in reversing transient tachypnea of newborns with decreasing respiratory rate compared to normal saline nebulization (placebo).

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Effects of Nebulized Albuterol in Transient Tachypnea of the Newborn A Clinical Trial

Cited by 7 publications

References 11 publications

Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

Effects of Salbutamol and Furosemide in The Treatment of Transient Tachypnea of Newborn - A Randomized Controlled Trial

Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

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