Effects of Nebulized Bronchodilator Therapy on Heart Rate and Arrhythmias in Critically Ill Adult Patients

Cardiovascular safety of new inhaled medications for asthma and chronic obstructive pulmonary disease: a critical review from pharmacist perspective

“…8,23,24 Increased HR is an independent risk factor for cardiomyopathy, myocardial infarction (MI), cardiovascular mortality, and atrial fibrillation (AF). 24 It is estimated that every 15 bpm increase in HR is associated with an increased risk of AF by 15%. 24 The study by Kallergis EM et al has found significant changes in cardiac electrophysiologic properties with SABA use.…”

“…24 It is estimated that every 15 bpm increase in HR is associated with an increased risk of AF by 15%. 24 The study by Kallergis EM et al has found significant changes in cardiac electrophysiologic properties with SABA use. 23 When SABA was used for subjects with cardiovascular and other comorbidities, some studies reported increased risk of arrhythmia.…”

“…23 When SABA was used for subjects with cardiovascular and other comorbidities, some studies reported increased risk of arrhythmia. 24,25 A study investigated 70 critically ill adults that reported 5 incidences of ventricular arrhythmia within recommended doses of SABA, without observing significant increases in HR. 24 In addition, a large cohort study has concluded that the use of beta-2 agonists (both SABA and LABA) was associated with a modest increased risk of arrhythmia, including AF, atrial flutter, and fatal arrhythmias.…”

Supraventricular tachycardia after nebulized salbutamol therapy in a neonate. Case report

“…Tachycardia and tachyarrhythmias are very common in critically ill adult patients with various conditions. 11 Predisposing factors for SVT include congenital heart disease, fever, and sympathomimetics. 8,12 Our patient had no history of congenital heart disease or fever.…”

A case report with supraventricular tachycardia secondary to albuterol treatment

“…1 Taşikardi ve kardiyak aritmiler çocuk hastalarda sıkça görülen yan etkileri arasındadır. Etki mekanizması olarak primer olarak beta-1 reseptörlerinin ekspresör etkisine refleks olarak gelişen periferik vazodilatasyon ile kalp atım hızını uyardığı gösterilmiştir.…”