Effects of nefopam on visual tracking

Bipolar disorder: candidate drug targets

“…At this time, pentazocine is not advocated for clinical use because excessive doses could lead to serious intoxication 33 and because there have been reports that it induces symptoms of depression and ''gloominess'' in healthy volunteers. 34 However, it will be interesting to follow up this preliminary study with controlled, proof-ofprinciple studies using more selective kappa opiate agonists in the treatment of mania in order to determine the relevance of kappa opioid receptors in BPD.…”

A review of the effects of opioids on psychomotor and cognitive functioning in humans.

“…In another study, a low dose of pentazocine did not affect tapping speed (Saarialho-Kere, Mattila, & Seppala, 1988). Of three studies examining the effect of pentazocine on tracking (i.e., on eye–hand coordination) in healthy volunteers (Belleville, Dorey, & Bellville, 1979; Bradley & Nicholson, 1987; Stacher, Steinringer, et al, 1982), only one study (Belleville et al, 1979) found impairment. This study used the highest dose in any of the three studies.…”

“…This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. Psychophysical, perceptual, and physiological processes Saarialho- Kere et al, 1986Manner, Kanto, Scheinin, et al, 1987Saarialho-Kere, Manila, et al, 1988Lamas et al, 1994Saarialho-Kere et al, 1986Saarialho-Kere, Manila, et al, 1988Bradley & Nicholson, 1987Stacher et al, 1982°S aarialho-Kere et al, 1986Manner, Kanto, Scheinin, et al, 1987Bradley & Nicholson, 1987Saarialho-Kere, Manila, et al, 1988Saarialho-Kere et al, 1986Saarialho-Kere, Manila, et al, 1988C Bradley & Nicholson, 1987Belleville et al, 1979C Bradley & Nicholson, 1987Saarialho-Kere et al, 1986Bradley & Nicholson, 1987Saarialho-Kere, Manila, et al, 1988Preston et al, 1992Strain et al, 1993 M/F, healthy volunteers (10) 0, 75 mg (PO) M/F, healthy volunteers (6) 0, 21, 42 mg b (IV) M/F, healthy volunteers (11) 0, 30 mg (PO) M, opioid dependent (6) 0, 46, 60 mg (IM) M/F, healthy volunteers (10) 0, 75 mg (PO) M/F, healthy volunteers (11) 0, 30 mg (PO) F, healthy volunteers (7) 0, 25, 50 mg (PO) M/F, healthy volunteers (24) 0.4 mg/kg/hr (infusion) M/F, healthy volunteers (10) 0, 75 mg (PO) M/F, healthy volunteers (6) 0, 21, 42 mg b (IV) F, healthy volunteers (7) 0, 25, 50 mg (PO) M/F, healthy volunteers (11) 0, 30 mg (PO) M/F, healthy volunteers (10) 0, 75 mg (PO) Simple motor performance and RT M/F, healthy volunteers (11) 0, 30 mg (PO) M/F, healthy volunteers (24) 0.4 mg/kg/hr (infusion) F, healthy volunteers (7) 0, 25, 50 mg (PO) M, healthy volunteers (7) 0, 22.5, 45 mg (IM) M/F, healthy volunteers (24) 0.4 mg/kg/hr (infusion) F, healthy volunteers ( 7 study examining higher doses of pentazocine reported impairment on the DSST . Methadone-maintained patients who were given relatively high doses of pentazocine did not have impaired performance on the DSST (Strain et al, 1993).…”

The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance

“…Comer et al (1996) reported improvement in tracking ability on a divided attention task after 10-mg d-amphetamine. Performance on tracking tasks has also been examined with sleep-deprived volunteers (Magill et al 2003;Belleville et al 1979), in which a dose of either 10-or 20-mg d-amphetamine significantly improved tracking performance.…”