Effects of Neonatal and Adult Thyroid Dysfunction on Thymic Oxytocin

Argiolas, Antonio; Gl, Gessa; Melis, Maria Rosaria; Stancampiano, Roberto; Vaccari, Andrea

doi:10.1159/000125643

Cited by 16 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of ir-OT was recently confirmed in fetal human thymus (Jevremovic et al, 1990) and in rat thymus (Argiolas et al, 1990a). The finding of a modulation of rat thymic ir-OT concentrations after diverse manipulations further supports a local intrathymic synthesis of an OT-like peptide (Argiolas et al, 1990b (Fig. 2C).…”

Section: Evidence For Neurohypophysial-like Peptides In Thymic Extractssupporting

confidence: 60%

The Recognition of Hypothalamo‐NeurohypophysialFunctions by Developing T Cells

Robert

Martens

Cormann

et al. 1992

Journal of Immunology Research

View full text Add to dashboard Cite

KEYWORDS:Neuropeptide signals and specific neuropeptide receptors have been described in the thymus supporting the concept of a close dialogue between the neuroendocrine and the immune systems at the level of early T-cell differentiation. In this paper, we review recent data about neurohypophysial (NHP)-related peptides detected in the thymus from different species. We suggest that we are dealing in fact with other member(s) of the NHP hormone family, which seems to exert its activity locally through a novel model of cell-to-cell signaling, that of cryptocrine communication. This model involves exchange of signals between thymic epithelial cells and developing thymocytes. The NHP-related peptides have been shown to trigger thymocyte proliferation and could induce immune tolerance of this highly conserved neuroendocrine family.Oxytocin, vasopressin, thymic epithelium, neurohypophysial peptide receptors, self-recognition, cryptocrine signaling. INTRODUCTIONIn the last decade, a number of studies has been reported indicating that various neuropeptides could be found in the thymus or in thymic neoplasms. Thus, neurotensin (NT) (Sundler et al., 1978;Herbst et al., 1987), somatostatin (SS) (Sundler et al., 1978;Geppetti et al., 1987;Fuller and Verity, 1989;Gomariz et al., 1990), oxytocin (OT) (Geenen et al., 1986;Ervin et al., 1988; Argiolas et al., 1990a;Jevremovic et al., 1990), vasopressin (VP) (Markwick et al., 1986;Geenen et al., 1987;Giraud et al., 1990), neurophysins (NPs) (Geenen et al., 1986), tachykinins (TKs) (Geppetti et al., 1988;Weihe et al., 1989;Ericsson et al., 1990;Lorton et al., 1990;Piantelli et al., 1990), neuropeptide Y (NPY) (D'Andrea et al., 1989;Weihe et al., 1989;Ericsson et al., 1990), vasoactive intestinal peptide (VIP) (Felten et al., 1985;Gomariz et al., 1990;A1-Shawaf et al., 1991), calcitonin gene-related peptide (CGRP) (Geppetti et al., 1989;Weihe et al., 1989), opioid peptides (Von Gaudecker et al., 1986;Piantelli et al., 1990), corticotropin (ACTH) (Her.bst et al., 1987), cholecystokinin (CCK) (Herbst et al., 1987), and atrial *Corresponding author. natriuretic peptide (ANP) (Vollmar and Schulz, 1990) have been immunologically, biologically, biochemically, and/or molecularly evidenced. These neuropeptides were not systematically located in the thymic structures. However, some immunoreactive (ir-) neuropeptides were localized in nerve fibers: substance P (SP) (Geppetti et al., 1987(Geppetti et al., , 1988Weihe et al., 1989;Lorton et al., 1990), CGRP (Weihe et al., 1989), VIP (Felten et al., 1985;A1-Shawaf et al., 1991), NPY (D'Andrea et al., 1989;Weihe et al., 1989). On the other hand, it was suggested that ANP could be localized in thymocytes (Vollmar and Schulz, 1990). Furthermore, NT and SS immunoreactivities were found in sparse stromal cells (Sundler et al., 1978), whereas neurokinin A (NKA) (Ericsson et al., 1990), opioid peptides (Von Gaudecker et al., 1986;Piantelli et al., 1990), OT, VP, and NPs (Robert et al., 1991) were localized in thymic epithelial c...

show abstract

Section: Evidence For Neurohypophysial-like Peptides In Thymic Extractssupporting

confidence: 60%

The Recognition of Hypothalamo‐NeurohypophysialFunctions by Developing T Cells

Robert

Martens

Cormann

et al. 1992

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…The analogy between TNC and testicular Sertoli cells is further supported by the recent observation of the expression of an oxytocin (OT) gene in cattle Sertoli cells (31), as weil as by the immuno-Iabelling of human Sertoli cells with mAbs A2B5 and 033 (directed against the cyclic part of OT (32)) (unpublished observations). If the molecular mechanisms under-Iying the intrathymic expression of NHP-like peptides remain to be further characterized, separate studies have confirmed the presence in the thymus of immunoreactive and bioactive OT-like peptide (33)(34)(35). Furthermore, the expression of functional NHP peptide receptors by rat thymocytes (36) and by murine immature and differentiated T cells is a prerequisite in favor of this working hypothesis (37).…”

Section: Gell-gell Interagtions In the Thymusmentioning

confidence: 99%

The thymic education of developing T cells in self neuroendocrine principles

Geenen

Robert

Martens

et al. 1992

J Endocrinol Invest

View full text Add to dashboard Cite

“…24 Moreover, a role for T, in the thymic OT system has been proposed. 25 We have initiated studies to determine if T3 has a role in regulation of OT gene expression in the HNS. In preliminary studies in animals with experimental hyper-or hypothyroidy OT mRNA levels, the OT content of the pituitary gland and OT plasma levels indicate that the influence of the thyroid hormones is not prominent in male adult animals.…”

Section: Regulation Of Oxytocin Promoter Activity By Thyroid Hormonementioning

confidence: 99%