Effects of Neonatal Irradiation and Genotype on Postnatal Growth in Mice

Dj, Nash

doi:10.1159/000240342

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…In neonates this includes long bones 40 , 51 . Exposure to total body irradiation is associated with decreased stature across species 34 , 38 , 39 , 52 , 53 . It is generally agreed that growth impairment correlates directly with the dose of irradiation and inversely with the age of exposure 40 , 54 .…”

Section: Discussionmentioning

confidence: 99%

Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility

Laky

Dugan

Frischmeyer‐Guerrerio

2018

Sci Rep

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Efficient hematopoietic reconstitution of wild type mice requires preconditioning. Established experimental protocols exist to transplant hematopoietic stem cells into lethally irradiated or chemically myeloablated adult mice or unirradiated immunodeficient mice. We sought to develop a protocol to reconstitute immuno-replete neonatal mice. We describe irradiation and injection procedures for two-day old mice that lead to efficient long-term reconstitution of primary and secondary lymphoid organs. We demonstrate that the frequencies of lymphoid and myeloid cells in primary and secondary lymphoid organs are indistinguishable from unirradiated uninjected sex- and age-matched control animals by 5 weeks post-reconstitution. Thus, this system will facilitate studies aimed at understanding the developmental and environmental mechanisms that contribute to conditions that have a window of susceptibility during the perinatal period.

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Section: Discussionmentioning

confidence: 99%

Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility

Laky

Dugan

Frischmeyer‐Guerrerio

2018

Sci Rep

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Margaret Kennard (1899–1975): Not a ‘Principle’ of brain plasticity but a founding mother of developmental neuropsychology

Dennis

2010

Cortex

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According to the 'Kennard Principle', there is a negative linear relation between age at brain injury and functional outcome. Other things being equal, the younger the lesioned organism, the better the outcome. But the 'Kennard Principle' is neither Kennard's nor a principle. In her work, Kennard sought to explain the factors that predicted functional outcome (age, to be sure, but also staging, laterality, location, and number of brain lesions, and outcome domain) and the neural mechanisms that altered the lesioned brain's functionality. This paper discusses Kennard's life and years at Yale (1931Yale ( -1943; considers the genesis and scope of her work on early-onset brain lesions, which represents an empirical and theoretical foundation for current developmental neuropsychology; offers an historical explanation of why the 'Kennard Principle' emerged in the context of early 1970s work on brain plasticity; shows why uncritical belief in the 'Kennard Principle' continues to shape current research and practice; and reviews the continuing importance of her work.

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Chapter 16. Atherosclerosis

Blohm

1972

Annual Reports in Medicinal Chemistry

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Effects of Neonatal Irradiation and Genotype on Postnatal Growth in Mice

Cited by 3 publications

References 3 publications

Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility

Hematopoietic reconstitution of neonatal immunocompetent mice to study conditions with a perinatal window of susceptibility

Margaret Kennard (1899–1975): Not a ‘Principle’ of brain plasticity but a founding mother of developmental neuropsychology

Chapter 16. Atherosclerosis

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