Effects of Neospora caninum on reproductive performance and the efficacy of treatment with a combination of sulphadiazine-trimethoprim and toltrazuril: a longitudinal field study

Canatan, H. E.; Polat, İbrahim; Bayramoglu, Rustem; Küplülü, Şükrü; Vural, Mehmet Rıfat; Aktug, E.

doi:10.17221/7241-vetmed

Cited by 6 publications

(4 citation statements)

References 48 publications

(70 reference statements)

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“…Antibody responses to N. caninum had unfavorable genetic associations with fertility traits in the present study, which is similar to reported phenotypic associations (Hall et al, 2005;Canatan et al, 2014). In a study of 486 Turkish dairy cows, Canatan et al (2014) reported cows positive for the antibody response to N. caninum required almost twice the number of inseminations and had, on average, a 77 d longer calving to conception interval compared to cows negative for the antibody response to the N. caninum. The increased odds of an abortion in N. caninum infected animals was 3.5 (the median value from a review of 10 studies) in dairy cows (Reichel et al, 2013).…”

Section: Genetic Correlations With Fertility Traitssupporting

confidence: 87%

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Twomey

Carroll

Doherty

et al. 2018

Journal of Animal Science

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Parasitic diseases have economic consequences in cattle production systems. Although breeding for parasite resistance can complement current control practices to reduce the prevalence globally, there is little knowledge of the implications of such a strategy on other performance traits. Records on individual animal antibody responses to Fasciola hepatica, Ostertagia ostertagi, and Neospora caninum were available from cows in 68 dairy herds (study herds); national abattoir data on F. hepatica-damaged livers were also available from dairy and beef cattle. After data edits, 9,271 dairy cows remained in the study herd dataset, whereas 19,542 dairy cows and 68,048 young dairy and beef animals had a record for the presence or absence of F. hepatica-damaged liver in the national dataset. Milk, reproductive, and carcass phenotypes were also available for a proportion of these animals as well as their contemporaries. Linear mixed models were used to estimate variance components of antibody responses to the three parasites; covariance components were estimated between the parasite phenotypes and economically important traits. Heritability of antibody responses to the different parasites, when treated as a continuous trait, ranged from 0.07 (O. ostertagi) to 0.13 (F. hepatica), whereas the coefficient of genetic variation ranged from 4% (O. ostertagi) to 20% (F. hepatica). The antibody response to N. caninum was genetically correlated with the antibody response to both F. hepatica (-0.29) and O. ostertagi (-0.67); a moderately positive genetic correlation existed between the antibody response to F. hepatica and O. ostertagi (0.66). Genetic correlations between the parasite phenotypes and the milk production traits were all close to zero (-0.14 to 0.10), as were the genetic correlations between F. hepatica-damaged livers and the carcass traits of carcass weight, conformation, and fat score evaluated in cows and young animals (0.00 to 0.16). The genetic correlation between F. hepatica-damaged livers in cows and milk somatic cell score was 0.32 (SE = 0.20). Antibody responses to F. hepatica and O. ostertagi had favorable genetic correlations with fertility traits, but conversely, antibody response to N. caninum and F. hepatica-damaged livers were unfavorably genetically correlated with fertility. This study provides the necessary information to undertake national multitrait genetic evaluations for parasite phenotypes.

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Section: Genetic Correlations With Fertility Traitssupporting

confidence: 87%

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Twomey

Carroll

Doherty

et al. 2018

Journal of Animal Science

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“…These results agree with some previous reports that also demonstrated an adverse effect of N. caninum on reproductive efficiency in dairy herds [38]. In particular, the number of inseminations for conception was higher in seropositive animals than in seronegative ones [7,8,39,40]. Although a few studies did not observe any influence of N. caninum infection in early pregnancy [33,41], it was suggested that an increase in the number of services necessary for cows to conceive may indicate embryonic death followed by fetal reabsorption, leading to a return to heat [9,42].…”

Section: Discussionsupporting

confidence: 92%

“…Although a few studies did not observe any influence of N. caninum infection in early pregnancy [33,41], it was suggested that an increase in the number of services necessary for cows to conceive may indicate embryonic death followed by fetal reabsorption, leading to a return to heat [9,42]. Moreover, some studies also reported an increased calving to conception interval in seropositive cows [9,39,40].…”

Section: Discussionmentioning

confidence: 99%

The Utility of Serological Analysis for Neospora caninum Infection in Dairy Cattle Farms Management: Serological Investigation and Evaluation of the Effects on Reproductive and Productive Performances in Two Study Herds in Northern Italy

Villa

Gazzonis

Fumagalli³

et al. 2022

Animals

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Neospora caninum is recognized as a major cause of abortion in cattle, determining economic losses, particularly in dairy industries. To evaluate the impact of neosporosis on herd efficiency, and to understand how the serological analysis for N. caninum is explicative of the farm picture, an epidemiological study was designed in two dairy farms recruited as a case study. Blood samples were collected from 540 animals, including cows and heifers over 12 months, and analyzed by an indirect immunofluorescent antibody test with subsequent antibody titration. Overall, 94 animals (17.4%) were identified as positive to N. caninum antibodies (15.5% and 18.5% in Farm 1 and Farm 2), with differences between the farms concerning the antibody titers (Chi-square, p-value = 0.04), particularly in cows (Chi-square, p-value = 0.018). Consequently, a different pattern of abortion episodes was depicted in the two investigated farms. Considering reproductive and productive performances, the number of inseminations necessary to make an animal pregnant was higher in seropositive cows (2.4 and 2.9 in Farm 1 and 2, respectively) than in seronegative ones (2.1 and 2.4 in Farm 1 and 2, respectively). Similarly, particularly in Farm 1, the number of days in milk of not-pregnant cows was higher in seropositive (167.7) than seronegative animals (133.4). Moreover, although the association between N. caninum infection and milk production is still unclear, both the daily milk production and the 305-mature equivalent milk yield were lower in seropositive (31.02 and 11,838.94) than seronegative cows (33.59 and 12,274.88) in Farm 1; an opposite pattern was otherwise depicted in Farm 2. The study showed that even if N. caninum circulated equally in the two herds, the dynamics of the parasite infection and its outcome may be different, also depending on the specific situation of the farm. In this way, the integration of serological analysis for N. caninum, the reproductive and productive parameters, and the information on herd performances, could give specific indications for the application of control strategies.

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“…In addition, the increased seroprevalence found in cows with repeated breeding syndrome supports the results of previous research conducted in Turkey (Canatan et al, 2014), Greece (Lefkaditis et al, 2020), and Italy (Villa et al, 2022), which demonstrated the adverse effects of N. caninum infection on the reproductive capacity of animals. According to the studies cited, the number of inseminations per conception was higher among seropositive animals compared to seronegative animals.…”

Section: Resultssupporting

confidence: 87%

SEROLOGICAL SCREENING FOR Neospora caninum INFECTION IN A DAIRY CATTLE FARM WITH REPRODUCTIVE DISORDERS, IN SOUTH-EASTERN ROMANIA

GOTU,

MITREA,

POREA

et al. 2023

AGROLIFE

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Neospora caninum is an apicomplexan protozoa parasite that causes reproductive disorders in cattle worldwide. Despite the high seroprevalence reported in Romania, there are limited data on N. caninum infection in dairy cattle, and no studies have evaluated the presence of infection over time in a limited area. Therefore, this study aimed to assess the seroprevalence of N. caninum in a dairy cattle farm in Southeastern Romania where a previously study reported about the cattle exposure to N. caninum infection. A total of 85 cattle, assigned in four groups, according to the reproductive status (repeated breeding syndrome, history of abortion, pregnant cows, and fresh cows) were tested for the presence of N. caninum antibodies, using an indirect ELISA test. The overall seroprevalence was 28.23% (95% CI: 18.67–37.80). According to the reproductive groups, the seroprevalence varied between 19.04% (95% CI: 2.25-35.84) in fresh cows to 38.09% (95% CI: 17.32 - 58.87) in cows with repeated breeding syndrome. By these findings new information is provided about the disease's presence in the studied farm, implying that infection with N. caninum may be the primary cause of reported reproductive disorders, as well as about the infection's persistent nature.

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Effects of Neospora caninum on reproductive performance and the efficacy of treatment with a combination of sulphadiazine-trimethoprim and toltrazuril: a longitudinal field study

Cited by 6 publications

References 48 publications

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

Genetic correlations between endo-parasite phenotypes and economically important traits in dairy and beef cattle1

The Utility of Serological Analysis for Neospora caninum Infection in Dairy Cattle Farms Management: Serological Investigation and Evaluation of the Effects on Reproductive and Productive Performances in Two Study Herds in Northern Italy

SEROLOGICAL SCREENING FOR Neospora caninum INFECTION IN A DAIRY CATTLE FARM WITH REPRODUCTIVE DISORDERS, IN SOUTH-EASTERN ROMANIA

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